Chronic thromboembolic pulmonary hypertension: Time for research in pathophysiology to catch up with developments in treatment

F1000Prime Reports

Volumn 6, Issue , 2014, Pages

  Toshner, Mark ^a   Pepke Zaba, Joanna ^a  

^a PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; DISEASE MODEL; ENDARTERECTOMY; HEART FUNCTION; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; THROMBUS; TRANSLATIONAL RESEARCH;

EID: 84903178602     PISSN: None     EISSN: 20517599     Source Type: Journal    
DOI: 10.12703/P6-38     Document Type: Review

References (50)

1. Moser KM, Bloor CM: Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension. Chest 1993, 103:685-92.
2. Yi ES, Kim H, Ahn H, Strother J, Morris T, Masliah E, Hansen LA, Park K, Friedman PJ: Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study Am J Respir Crit Care Med 2000, 162:1577-86.
3. Lang IM, Pesavento R, Bonderman D, Yuan JX: Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J 2013, 41:462-8.
4. Barnes AR, Yater WM: Failure of right ventricle due to ancient thrombus in the pulmonary arteries. M Clin North America 1929, 12.
5. Pengo V, Lensing, Anthonie WA, Prins MH, Marchiori A, Davidson BL, Tiozzo F, Albanese P, Biasiolo A, Pegoraro C, Iliceto S, Prandoni P: Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 2004, 350:2257-64.
6. Ribeiro A, Lindmarker P, Johnsson H, Juhlin-Dannfelt A, Jorfeldt L: Pulmonary embolism: one-year follow-up with echocardiography doppler and five-year survival analysis. Circulation 1999, 99:1325-30.
7. Becattini C, Agnelli G, Pesavento R, Silingardi M, Poggio R, Taliani MR, Ageno W: Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest 2006, 130:172-5.
8. Miniati M, Monti S, Bottai M, Scoscia E, Bauleo C, Tonelli L, Dainelli A, Giuntini C: Survival and restoration of pulmonary perfusion in a long-term follow-up of patients after acute pulmonary embolism. Medicine (Baltimore) 2006, 85:253-62.
9. Martí D, Gómez V, Escobar C, Wagner C, Zamarro C, Sánchez D, Sam A, Briongos S, Gaudó J, Sueiro A, Jiménez D: Incidencia de hipertensión pulmonar tromboembólica crónica sintomática y asintomática. Arch Bronconeumol 2010, 46:628-33.
10. Klok FA, Zondag W, van Kralingen, Klaas W, van Dijk, Arie PJ, Tamsma JT, Heyning FH, Vliegen HW, Huisman MV: Patient outcomes after acute pulmonaryembolism. A pooled survival analysis of different adverse events Am J Respir Crit Care Med 2010, 181:501-6.
11. Bonderman D, Jakowitsch J, Adlbrecht C, Schemper M, Kyrle PA, Schönauer V, Exner M, Klepetko W, Kneussl MP, Maurer G, Lang I: Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension. Thromb Haemost 2005, 93:512-6.
12. Condliffe R, Kiely DG, Gibbs JSR, Corris PA, Peacock AJ, Jenkins DP, Goldsmith K, Coghlan JG Pepke-Zaba J: Prognostic and aetiological factors in chronic thromboembolic pulmonary hypertension. Eur Respir J 2009, 33:332-8.
13. Pepke-Zaba J, Delcroix M, Lang I, Mayer E, Jansa P, Ambroz D, Treacy C, D'Armini AM, Morsolini M, Snijder R, Bresser P, Torbicki A, Kristensen B, Lewczuk J, Simkova I, Barberà JA, Perrot M de, Hoeper MM, Gaine S, Speich R, Gomez-Sanchez MA, Kovacs G, Hamid AM, Jaïs X, Simonneau G: Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry. Circulation 2011, 124:1973-81.
14. Jamieson SW, Auger WR, Fedullo PF, Channick RN, Kriett JM, Tarazi RY, Moser KM: Experience and results with 150 pulmonary thromboendarterectomy operations over a 29-month period. J Thorac Cardiovasc Surg 1993, 106:116-26; discussion 126-7.
15. Gailani D, Renné T: The intrinsic pathway of coagulation: a target for treating thromboembolic disease? J Thromb Haemost 2007, 5:1106-12.
16. Mackman N, Tilley RE, Key NS: Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 2007, 27:1687-93.
17. Kim NH, Delcroix M, Jenkins DP, Channick R, Dartevelle P, Jansa P, Lang I, Madani MM, Ogino H, Pengo V, Mayer E: Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 2013, 62:D92-9.
18. Bonderman D, Turecek PL, Jakowitsch J, Weltermann A, Adlbrecht C, Schneider B, Kneussl M, Rubin LJ, Kyrle PA, Klepetko W, Maurer G, Lang IM: High prevalence of elevated clotting factor VIII in chronic thromboembolic pulmonary hypertension. Thromb Haemost 2003, 90:372-6.
19. Quarck R, Nawrot T, Meyns B, Delcroix M: C-reactive protein: a new predictor of adverse outcome in pulmonary arterial hypertension. J Am Coll Cardiol 2009, 53:1211-8.
20. Langer F, Schramm R, Bauer M, Tscholl D, Kunihara T, Schäfers H: Cytokine response to pulmonary thromboendarterectomy. Chest 2004, 126:135-41.
21. Kimura H, Okada O, Tanabe N, Tanaka Y, Terai M, Takiguchi Y, Masuda M, Nakajima N, Hiroshima K, Inadera H, Matsushima K, Kuriyama T: Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med 2001, 164:319-24.
22. Bonderman D, Jakowitsch J, Redwan B, Bergmeister H, Renner M, Panzenböck H, Adlbrecht C, Georgopoulos A, Klepetko W, Kneussl M, Lang IM: Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension. Arterioscler Thromb Vasc Biol 2008, 28:678-84.
23. Lang IM, Marsh JJ, Olman MA, Moser KM, Loskutoff DJ, Schleef RR: Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Circulation 1994, 89:2715-21.
24. Firth AL, Yao W, Ogawa A, Madani MM, Lin GY, Yuan JX: Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am Physiol J Cell Physiol 2010, 298:C1217-25.
25. Morris TA, Marsh JJ, Chiles PG, Auger WR, Fedullo PF, Woods VL: Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis. Am J Respir Crit Care Med 2006, 173:1270-5.
26. Suntharalingam J, Goldsmith K, van Marion V, Long L, Treacy CM, Dudbridge F, Toshner MR, Pepke-Zaba J, Eikenboom, JCJ, Morrell NW: Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension. Eur Respir J 2008, 31:736-41.
27. Li J, Lin Y, Yang Y, Gan H, Liang Y, Liu J, Yang S, Zhang W, Cui N, Zhao L, Zhai Z, Wang J, Wang C: Fibrinogen Aa Thr312Ala polymorphism specifically contributes to chronic thromboembolic pulmonary hypertension by increasing fibrin resistance. PLoS ONE 2013, 8:e69635.
28. Standeven KF, Grant PJ, Carter AM, Scheiner T, Weisel JW, Ariëns, Robert AS: Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function. Circulation 2003, 107:2326-30.
29. Morris TA, Marsh JJ, Chiles PG, Magaña MM, Liang N, Soler X, Desantis DJ, Ngo D, Woods VL: High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. Blood 2009, 114:1929-36.
30. Marsh JJ, Chiles PG, Liang N, Morris TA: Chronic thromboembolic pulmonary hypertension-associated dysfibrinogenemias exhibit disorganized fibrin structure. Thromb Res 2013, 132: 729-34.
31. Mercier O, Fadel E: Chronic thromboembolic pulmonary hypertension: animal models. Eur Respir J 2013, 41:1200-6.
32. Frey MK, Alias S, Winter MP, Redwan B, Stübiger G, Panzenboeck A, Alimohammadi A, Bonderman D, Jakowitsch J, Bergmeister H, Bochkov V, Preissner KT, Lang IM: Splenectomy is modifying the vascular remodeling of thrombosis. J Am Heart Assoc 2014, 3:e000772.
33. Alias S, Redwan B, Panzenböck A, Winter MP, Schubert U, Voswinckel R, Frey MK, Jakowitsch J, Alimohammadi A, Hobohm L, Mangold A, Bergmeister H, Sibilia M, Wagner EF, Mayer E, Klepetko W, Hölzenbein TJ, Preissner KT, Lang IM: Defective angiogenesis delays thrombus resolution: a potential pathogenetic mechanism underlying chronic thromboembolic pulmonary hypertension. Arterioscler Thromb Vasc Biol 2014, 34:810-9.
34. Quarck R, Wynants M, Ronisz A, Sepulveda MR, Wuytack F, van Raemdonck D, Meyns B, Delcroix M: Characterization of proximal pulmonary arterial cells from chronic thromboembolic pulmonary hypertension patients. Respir Res 2012, 13:27.
35. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX: Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2009, 296:L870-8.
36. McCabe C, White PA, Hoole SP, Axell RG, Priest AN, Gopalan D, Taboada D, MacKenzie Ross R, Morrell NW, Shapiro LM, Pepke-Zaba J: Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery: a pressure-volume study using the conductance catheter. J Appl Physiol 2014, 116:355-63.
37. Reesink HJ, Marcus JT, Tulevski II, Jamieson S, Kloek JJ, Vonk Noordegraaf A, Bresser P: Reverse right ventricular remodeling after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: utility of magnetic resonance imaging to demonstrate restoration of the right ventricle. J Thorac Cardiovasc Surg 2007, 133:58-64.
38. MacKenzie Ross, Robert V, Toshner MR, Soon E, Naeije R, Pepke-Zaba J: Decreased time constant of the pulmonary circulation in chronic thromboembolic pulmonary hypertension. Am J Physiol Heart Circ Physiol 2013 305:H259-64.
39. Freed DH, Thomson BM, Tsui, Steven S L, Dunning JJ, Sheares KK, Pepke-Zaba J, Jenkins DP: Functional and haemodynamic outcome 1 year after pulmonary thromboendarterectomy. Eur J Cardiothorac Surg 2008, 34:525-9; discussion 529-30.
40. Madani MM, Auger WR, Pretorius V, Sakakibara N, Kerr KM, Kim NH, Fedullo PF, Jamieson SW: Pulmonary endarterectomy: recent changes in a single institution's experience of more than 2,700 patients. Ann Thorac Surg 2012, 94:97-103; discussion 103.
41. Mayer E, Jenkins D, Lindner J, D'Armini A, Kloek J, Meyns B, Ilkjaer LB, Klepetko W, Delcroix M, Lang I, Pepke-Zaba J, Simonneau G, Dartevelle P: Surgical management and outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective registry. J Thorac Cardiovasc Surg 2011, 141:702-10.
42. National Pulmonary Hypertension Audit 2012 report. Health and Social Care Information Centre (HSCIC); 2013. [http://www.hscic.gov.uk/searchcatalogue? productid=11350&infotype=0%2FAudit&sort=Most+recent&size= 50&page=1]
43. Suntharalingam J, Treacy CM, Doughty NJ, Goldsmith K, Soon E, Toshner MR, Sheares KK, Hughes R, Morrell NW, Pepke-Zaba J: Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension. Chest 2008, 134:229-36.
44. Jaïs X, D'Armini AM, Jansa P, Torbicki A, Delcroix M, Ghofrani HA, Hoeper MM, Lang IM, Mayer E, Pepke-Zaba J, Perchenet L, Morganti A, Simonneau G, Rubin LJ: Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. J Am Coll Cardiol 2008, 52:2127-34.
45. Feinstein JA, Goldhaber SZ, Lock JE, Ferndandes SM, Landzberg MJ: Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. Circulation 2001, 103:10-3.
46. Kataoka M, Inami T, Hayashida K, Shimura N, Ishiguro H, Abe T, Tamura Y, Ando M, Fukuda K, Yoshino H, Satoh T: Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv 2012, 5:756-62.
47. Mizoguchi H, Ogawa A, Munemasa M, Mikouchi H, Ito H, Matsubara H: Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv 2012, 5:748-55.
48. Sugimura K, Fukumoto Y, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H: Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension. Circ J 2012, 76:485-8.
49. Andreassen AK, Ragnarsson A, Gude E, Geiran O, Andersen R: Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. Heart 2013, 99:1415-20.
50. Inami T, Kataoka M, Shimura N, Ishiguro H, Yanagisawa R, Taguchi H, Fukuda K, Yoshino H, Satoh T: Pulmonary edema predictive scoring index (PEPSI), a new index to predict risk of reperfusion pulmonary edema and improvement of hemodynamics in percutaneous transluminal pulmonary angioplasty. JACC Cardiovasc Interv 2013, 6:725-36.