ARTICLE;
CANCER PATIENT;
COST CONTROL;
DRUG MONITORING;
HEALTH CARE COST;
HEALTH CARE PERSONNEL;
HUMAN;
MAINTENANCE THERAPY;
MAJOR CLINICAL STUDY;
NONHODGKIN LYMPHOMA;
OBSERVATIONAL STUDY;
OPEN STUDY;
PHASE 3 CLINICAL TRIAL;
PROSPECTIVE STUDY;
UNITED KINGDOM;
COMPARATIVE STUDY;
COST;
ECONOMICS;
INTRAVENOUS DRUG ADMINISTRATION;
LYMPHOMA, NON-HODGKIN;
NATIONAL HEALTH SERVICE;
OUTPATIENT DEPARTMENT;
PHASE 3 CLINICAL TRIAL (TOPIC);
SUBCUTANEOUS DRUG ADMINISTRATION;
TASK PERFORMANCE;
ADMINISTRATION, INTRAVENOUS;
ANTIBODIES, MONOCLONAL, MURINE-DERIVED;
ANTINEOPLASTIC AGENTS;
CLINICAL TRIALS, PHASE III AS TOPIC;
COSTS AND COST ANALYSIS;
GREAT BRITAIN;
HEALTH PERSONNEL;
HUMANS;
INJECTIONS, SUBCUTANEOUS;
LYMPHOMA, NON-HODGKIN;
OUTPATIENT CLINICS, HOSPITAL;
PROSPECTIVE STUDIES;
STATE MEDICINE;
TIME AND MOTION STUDIES;
International Agency for Research on Cancer. GLOBOCAN. Accessed January 15 2014
International Agency for Research on Cancer. GLOBOCAN. http://globocan. iarc.fr. Accessed January 15, 2014
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Roche. MabThera Summary of Product Characteristics. Accessed January 15 2014
Roche. MabThera Summary of Product Characteristics. http://www.ema. europa. eu/docs/en-GB/document-library/EPAR-Product-Information/human/000165/ WC500025821.pdf. Accessed January 15, 2014
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84903197980
Roche. MabThera- receives marketing authorization in the European Union. Accessed January 15 2014
Roche. MabThera- receives marketing authorization in the European Union. http://www.roche.com/static/app/news/media-news-1998-06-03-e.pdf. Accessed January 15, 2014
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Roche. MabThera approved in Europe for first line maintenance treatment of follicular lymphoma, a common type of blood cancer. Accessed January 15 2014
Roche. MabThera approved in Europe for first line maintenance treatment of follicular lymphoma, a common type of blood cancer. http://www.roche.com/ media/media-releases/med-cor-2010-10-29.htm. Accessed January 15, 2014
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Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Tilly H, Vitolo U, Walewski J, et al. Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012;23:vii78-vii82
Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Dreyling M, Ghielmini M, Marcus R, et al. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011;22:vi59-vi63
Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group
DOI 10.1182/blood-2005-01-0016
Hiddemann W, Kneba M, Dreyling M, et al. Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood 2005;106:3725-32 (Pubitemid 41742196)
Recombinant human hyaluronidase (rHuPH20): An enabling platform for subcutaneous drug and fluid administration
DOI 10.1517/17425247.4.4.427
Frost GI. Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administration. Expert Opin Drug Deliv 2007;4:427-40 (Pubitemid 47249140)
Pharmacokinetics (PK safety and overall response rate (ORR) achieved with subcutaneous (SC) administration of rituximab in combination with chemotherapy were comparable to those achieved with intravenous (IV) administration in patients ( pts) with follicular lymphoma (FL) in the first-line setting: Stage 1 results of the phase III SABRINA study (BO22334)
Davies A, Merli F, Mihaljevik B, et al. Pharmacokinetics (PK), safety and overall response rate (ORR) achieved with subcutaneous (SC) administration of rituximab in combination with chemotherapy were comparable to those achieved with intravenous (IV) administration in patients ( pts) with follicular lymphoma (FL) in the first-line setting: stage 1 results of the phase III SABRINA study (BO22334). ASH Annual Meeting Abstracts 2012;120:1629
A two-stage phase Ib study to investigate the pharmacokinetics, safety and tolerability of subcutaneous rituximab in patients with follicular lymphoma as part of maintenance treatment
Salar A, Bouabdallah R, McIntyre C, et al. A two-stage phase Ib study to investigate the pharmacokinetics, safety and tolerability of subcutaneous rituximab in patients with follicular lymphoma as part of maintenance treatment. ASH Annual Meeting Abstracts 2010;116:2858
NHS Agenda for Change-pay rates. Accessed January 15 2014
NHS Agenda for Change-pay rates. http://www.nhscareers.nhs.uk/workingin- the-nhs/pay-and-benefits/agenda-for-change-pay-rates. Accessed January 15, 2014
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Subcutaneous trastuzumab (Herceptin-): A UK time and motion study in comparison with intravenous formulation for the treatment of patients with HER2-positive early breast cancer
Burcombe R, Chan S, Simcock R, et al. Subcutaneous trastuzumab (Herceptin-): a UK time and motion study in comparison with intravenous formulation for the treatment of patients with HER2-positive early breast cancer. Adv Breast Cancer Res 2013;2:133-40