Diffuse large B-cell lymphoma (DLBCL): ESMO clinical practice guidelines for diagnosis, treatment andfollow-up

Annals of Oncology

Volumn 23, Issue SUPPL. 7, 2012, Pages

  Tilly, H ^a   Vitolo, U ^b   Walewski, J ^c   Da silva, M Gomes ^d   Shpilberg, O ^e   Andre M ^f   Pfreundschuh, M ^g   Dreyling, M ^h  

^a CENTRE HENRI BECQUEREL   (France)

^b MOLINETTE HOSPITAL   (Italy)

^c INSTITUTE OF ONCOLOGY   (Poland)

^d INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^e RABIN MEDICAL CENTER   (Israel)

^f UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^g SAARLAND UNIVERSITY   (Germany)

^h UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARABINOSIDE; BLEOMYCIN; CARBOPLATIN; CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOSINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; IFOSFAMIDE; MELPHALAN; METHOTREXATE; OXALIPLATIN; PREDNISONE; RITUXIMAB; VINCRISTINE; VINDESINE;

ALLOTRANSPLANTATION; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INCIDENCE; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CHEMOPROPHYLAXIS; CLINICAL PRACTICE; DOSE RESPONSE; DRUG MEGADOSE; DRUG RESPONSE; ELDERLY CARE; HIGH RISK PATIENT; HUMAN; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LYMPH NODE BIOPSY; MULTIPLE CYCLE TREATMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 84866612790     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mds273     Document Type: Article

References (39)

1. Morgan G, Vornanen M, Puitinen J et al. Changing trends in the incidence of non-Hodgkin's lymphoma in Europe. Biomed Study Group. Ann Oncol 1997; 8 (Suppl 2): 49-54.
2. Swerdlow SH, Campo E, Harris NL et al. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC 2008.
3. Held G, Pfreundschuh M. Hematology: germinal center or nongerminal center DLBCL? Nat Rev Clin Oncol 2009; 6: 188-190.
4. Cheson BD, Pfistner B, Juweid ME et al. Revised response criteria for malignant lymphoma. J Clin Oncol 2007; 25: 579-586.
5. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med 1993; 329: 987-994.
6. Pfreundschuh M, Trumper L, Osterborg A et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006; 7: 379-391.
7. Reyes F, Lepage E, Ganem G et al. ACVBP versus CHOP plus radiotherapy for localized aggressive lymphoma. N Engl J Med 2005; 352: 1197-1205.
8. Recher C, Coiffier B, Haioun C et al. Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial. Lancet 2011; 378: 1858-1867.
9. Pfreundschuh M, Ho AD, Cavallin-Stahl E et al. Prognostic significance of maximum tumour (bulk) diameter in young patients with good-prognosis diffuse large-B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: an exploratory analysis of the MabThera International Trial Group (MInT) study. Lancet Oncol 2008; 9: 435-444.
10. Cunningham D, Smith P, Mouncey P et al. R-CHOP14 versus R-CHOP21: result of a randomized phase III trial for the treatment of patients with newly diagnosed diffuse large B-cell non Hodgkin lymphoma. J Clin Oncol 2011 ASCO Annual Meeting Proceedings; 29(Suppl 15): (Abst 8000): 504s.
11. Tarella C, Zanni M, Di Nicola M et al. Prolonged survival in poor-risk diffuse large B-cell lymphoma following front-line treatment with rituximab-supplemented, early-intensified chemotherapy with multiple autologous hematopoietic stem cell support: a multicenter study by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi). Leukemia 2007; 21: 1802-1811.
12. Vitolo U, Chiappella A, Angelucci E et al. Dose-dense and high-dose chemotherapy plus rituximab with autologous stem cell transplantation for primary treatment of diffuse large B-cell lymphoma with a poor prognosis: a phase II multicenter study. Haematologica 2009; 94: 1250-1258.
13. Fitoussi O, Belhadj K, Mounier N et al. Survival impact of rituximab combined with ACVBP and upfront consolidation autotransplantation in high-risk diffuse large B-cell lymphoma for GELA. Haematologica 2011; 96: 1136-1143.
14. Stiff PJ, Unger JM, Cook J et al. Randomized phase III U.S./Canadian intergroup trial (SWOG S9704) comparing CHOP {+/-} R for eight cycles to CHOP {+/-} R for six cycles followed by autotransplant for patients with high-intermediate (HInt) or high IPI grade diffuse aggressive non-Hodgkin lymphoma (NHL). J Clin Oncol 2011; 29(Suppl 15): (Abst 8001) (ASCO Meeting Abstracts) 504s.
15. Vitolo U, Chiappella A, Brusamolino E et al. A randomized multicentre phase III study for first line treatment of young patients with high risk (AAIPI 2-3) diffuse large B-cell lymphoma (DLBCL): rituximab (R) plus dose-dense chemotherapy CHOP14/MEGACHOP14 with or without intnesified high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT). Results of DLCL04 trial of Italian Lymphoma Foundation (FIL). Ann Oncol 2011; 22: 106.
16. Schmitz N, Nickelsen M, Ziepert M et al. Conventional chemoimmunotherapy (RCHOEP- 14) or high-dose therapy (R-MEGA-CHOEP) for young, high-risk patients with aggressive B-cell lymphoma: Final results of the randomized MEGA-CHOEPTrial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Ann Oncol 2011; 22: 106-107.
17. Milpied N-J, Legouill S, Lamy T et al. No benefit of first-line rituximab (R)-highdose therapy (R-HDT) over R-CHOP14 for young adults with diffuse large b-cell lymphoma. Preliminary results of the GOELAMS 075 Prospective Multicentre Randomized Trial. J Clin Oncol 2010; 116: 685 (ASH Annual Meeting Abstracts 2010).
18. Moser EC, Kluin-Nelemans HC, Carde P et al. Impact of involved field radiotherapy in partial response after doxorubicin-based chemotherapy for advanced aggressive non-Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys 2006; 66: 1168-1177.
19. Coiffier B, Lepage E, Briere J et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 235-242.
20. Delarue R, Tilly H, Salles A et al. R-CHOP14 compared to R-CHOP21 in elderly patients with diffuse large B-cell lymphoma: results of the interim analysis of the LNH03-6B GELA study. Blood 2009; 114: (Abstracts 406) 52.
21. Pfreundschuh M, Schubert J, Ziepert M et al. Six versus eight cycles of biweekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 2008; 9: 105-116.
22. Bonnet C, Fillet G, Mounier N et al. CHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2007; 25: 787-792.
23. Peyrade F, Jardin F, Thieblemont C et al. Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial. Lancet Oncol 2011; 12: 460-468.
24. Kridel R, Dietrich PY. Prevention of CNS relapse in diffuse large B-cell lymphoma. Lancet Oncol 2011; 12: 1258-1266.
25. Tilly H, Lepage E, Coiffier B et al. Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non- Hodgkin lymphoma. Blood 2003; 102: 4284-4289.
26. Abramson JS, Hellmann M, Barnes JA et al. Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma. Cancer 2010; 116: 4283-4290.
27. Barosi G, Carella A, Lazzarino M et al. Management of nodal diffuse large B-cell lymphomas: practice guidelines from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. Haematologica 2006; 91: 96-103.
28. Ferreri AJ, Reni M, Foppoli M et al. High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial. Lancet 2009; 374: 1512-1520.
29. Zucca E, Conconi A, Mughal TI et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. J Clin Oncol 2003; 21: 20-27.
30. Vitolo U, Chiappella A, Ferreri AJ et al. First-line treatment for primary testicular diffuse large B-Cell lymphoma with rituximab-CHOP, CNS Prophylaxis, and contralateral testis irradiation: final results of an international phase II trial. J Clin Oncol. 2011; 29: 2766-2772.
31. Martelli M, Ferreri AJ, Johnson P. Primary mediastinal large B-cell lymphoma. Crit Rev Oncol Hematol 2008; 68: 256-263.
32. Armitage JO, Loberiza FR. Is there a place for routine imaging for patients in complete remission from aggressive lymphoma? Ann Oncol 2006; 17: 883-884.
33. Horwitz SM, Negrin RS, Blume KG et al. Rituximab as adjuvant to high-dose therapy and autologous hematopoietic cell transplantation for aggressive non- Hodgkin lymphoma. Blood 2004; 103: 777-783.
34. Kewalramani T, Zelenetz AD, Nimer SD et al. Rituximab and ICE as secondline therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma. Blood 2004; 103: 3684-3688.
35. Gisselbrecht C, Glass B, Mounier N et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol 2010; 28: 4184-4190.
36. Thieblemont C, Briere J, Mounier N et al. The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a Bio-CORAL study. J Clin Oncol 2011; 29: 4079-4087.
37. Gisselbrecht C, Glass B, Laurent G et al. Maintenance with rituximab after autologous stem cell transplantation in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL): CORAL final analysis. J Clin Oncol 2011; 29(Suppl). (abstr 8004) 505s.
38. Glass B, Hasenkamp J, Wulf G et al. High-dose chemotherapy followed by allogeneic stem cell transplantation in high-risk relapsed and refractory aggressive non-Hodgkin lymphoma: results of a prospective study of the German high-grade non-Hodgkin lymphoma study group. J Clin Oncol 2012; 30(Suppl). (abstr 8004).
39. El Gnaoui T, Dupuis J, Belhadj K et al. Rituximab, gemcitabine and oxaliplatin: an effective salvage regimen for patients with relapsed or refractory B-cell lymphoma not candidates for high-dose therapy. Ann Oncol 2007; 18: 1363-1368.