메뉴 건너뛰기




Volumn 24, Issue 7, 2014, Pages 829-837

Novel picolinamide-based cystic fibrosis transmembrane regulator modulators: Evaluation of WO2013038373, WO2013038376, WO2013038381, WO2013038386 and WO2013038390

Author keywords

CF; CFTR; Mucus secretion; Protein transport

Indexed keywords

CHLORIDE CHANNEL; GROWTH HORMONE; IVACAFTOR; LUMACAFTOR; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OXADIAZOLE DERIVATIVE; PICOLINAMIDE; UNCLASSIFIED DRUG; WO 2013038373; WO 2013038378; WO 2013038381; WO 2013038386; WO 2013038390; AMIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; PICOLINIC ACID DERIVATIVE;

EID: 84903159409     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2014.876412     Document Type: Article
Times cited : (10)

References (26)
  • 1
    • 84874726028 scopus 로고    scopus 로고
    • Targeting a genetic defect: Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis
    • Derich N. Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis. Eur Respir Rev 2013;22(127):58-65
    • (2013) Eur Respir Rev , vol.22 , Issue.127 , pp. 58-65
    • Derich, N.1
  • 2
    • 0032912589 scopus 로고    scopus 로고
    • Structure and function of the CFTR chloride channel
    • Sheppard DN, Welsh MJ. Structure and function of the CFTR chloride channel. Physiol Rev 1999;79(1 Suppl):S23-45 (Pubitemid 29058908)
    • (1999) Physiological Reviews , vol.79 , Issue.1 SUPPL. 1
    • Sheppard, D.N.1    Welsh, M.J.2
  • 3
    • 0027162649 scopus 로고
    • Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
    • DOI 10.1016/0092-8674(93)90353-R
    • Welsh MJ, Smith AE. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 1993;73(7):1251-4 (Pubitemid 23201140)
    • (1993) Cell , vol.73 , Issue.7 , pp. 1251-1254
    • Welsh, M.J.1    Smith, A.E.2
  • 4
    • 33744801247 scopus 로고    scopus 로고
    • Cystic fibrosis gene genetic analysis consortium
    • Tsui LC. Cystic fibrosis gene genetic analysis consortium. Hum Mutat 2001;4:167-77
    • (2001) Hum Mutat , vol.4 , pp. 167-177
    • Tsui, L.C.1
  • 5
    • 79952609106 scopus 로고    scopus 로고
    • Gene therapy for cystic fibrosis
    • Davies JC, Alton EW. Gene therapy for cystic fibrosis. Proc Am Thorac Soc 2010;7(6):408-14
    • (2010) Proc Am Thorac Soc , vol.7 , Issue.6 , pp. 408-414
    • Davies, J.C.1    Alton, E.W.2
  • 6
    • 84885388155 scopus 로고    scopus 로고
    • The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep
    • Alton EW, Baker A, Baker E, et al. The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep. Biomaterials 2013;34(38):10267-77
    • (2013) Biomaterials , vol.34 , Issue.38 , pp. 10267-10277
    • Alton, E.W.1    Baker, A.2    Baker, E.3
  • 7
    • 84868243529 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATPindependent manner
    • Eckford PD, Li C, Ramjeesingh M, Bear CE. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATPindependent manner. J Biol Chem 2012;287(44):36639-49
    • (2012) J Biol Chem , vol.287 , Issue.44 , pp. 36639-36649
    • Eckford, P.D.1    Li, C.2    Ramjeesingh, M.3    Bear, C.E.4
  • 8
    • 84883377550 scopus 로고    scopus 로고
    • Development, clinical utility, and place of ivacaftor in the treatment of cystic fibrosis
    • O'Reilly R, Elphick HE. Development, clinical utility, and place of ivacaftor in the treatment of cystic fibrosis. Drug Des Devel Ther 2013;7:929-37
    • (2013) Drug des Devel Ther , vol.7 , pp. 929-937
    • O'Reilly, R.1    Elphick, H.E.2
  • 10
    • 81755163563 scopus 로고    scopus 로고
    • Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
    • Van Goor F, Hadida S, Grootenhuis PD, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci USA 2011;108(46):18843-8
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.46 , pp. 18843-18848
    • Van Goor, F.1    Hadida, S.2    Grootenhuis, P.D.3
  • 13
    • 84864984030 scopus 로고    scopus 로고
    • Click-based synthesis of triazolobithiazole delta 508-CFTR correctors for cystic fibrosis
    • DonaldMB, Rodriguez KX, Shay H, et al. Click-based synthesis of triazolobithiazole delta 508-CFTR correctors for cystic fibrosis. BioorgMed Chem 2012;20(17):5247-53
    • (2012) BioorgMed Chem , vol.20 , Issue.17 , pp. 5247-5253
    • Donald, M.B.1    Rodriguez, K.X.2    Shay, H.3
  • 14
    • 84855202429 scopus 로고    scopus 로고
    • Results of a Phase IIa study of VX-809 an investigational CFTR corrector compound in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
    • Clancy JP, Rowe SM, Accurso FJ, et al. Results of a Phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax 2012;67(1):12-18
    • (2012) Thorax , vol.67 , Issue.1 , pp. 12-18
    • Clancy, J.P.1    Rowe, S.M.2    Accurso, F.J.3
  • 17
    • 85067726502 scopus 로고    scopus 로고
    • R&D Update. 2013. Available from
    • Galapagos NV, R&D Update. 2013. Available from: www.glpg.com/index. php/download-file/view/1440/1/
    • Galapagos, N.V.1
  • 19
    • 85067724954 scopus 로고    scopus 로고
    • Available from
    • Sun X, Sui J, Qiu J, et al. Available from: http://www.n30pharma.com/ docs/posters/2013-10-15-NACFC-Sun-poster.pdf
    • Sun, X.1    Sui, J.2    Qiu, J.3
  • 25
    • 84855691925 scopus 로고    scopus 로고
    • Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines
    • Hunt T, Atherton-Watson HC, Axford J, et al. Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines. Bioorg Med Chem Lett 2012;22(2):929-32
    • (2012) Bioorg Med Chem Lett , vol.22 , Issue.2 , pp. 929-932
    • Hunt, T.1    Atherton-Watson, H.C.2    Axford, J.3
  • 26
    • 81755163563 scopus 로고    scopus 로고
    • Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
    • Van Goor F, Hadida S, Grootenhuis PD, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci USA 2011;108(46):18843-87
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.46 , pp. 18843-18887
    • Van Goor, F.1    Hadida, S.2    Grootenhuis, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.