메뉴 건너뛰기




Volumn 14, Issue 6, 2014, Pages 635-637

Next-generation sequencing in precision oncology: Challenges and opportunities

Author keywords

Bioinformatics; ctDNA; Next generation sequencing; NGS; Personalized medicine; Precision oncology; Tumor heterogeneity

Indexed keywords

BIOINFORMATICS; CANCER DIAGNOSIS; CANCER RECURRENCE; CANCER SCREENING; CANCER THERAPY; CIRCULATING TUMOR CELL; CLONAL EVOLUTION; DNA DAMAGE; DNA SEQUENCE; GENE SEQUENCE; GENETIC RISK; GENETIC SCREENING; GENOMICS; HIGH RISK POPULATION; HIGH THROUGHPUT SEQUENCING; HUMAN; LABORATORY TEST; METASTASIS; MINIMAL RESIDUAL DISEASE; MUTATIONAL ANALYSIS; NEXT GENERATION SEQUENCING; ONCOLOGY; PATHOGENICITY; PATIENT MONITORING; PERSONALIZED MEDICINE; QUALITY OF LIFE; REVIEW; RISK ASSESSMENT; SOMATIC MUTATION; TUMOR MICROENVIRONMENT; GENETICS; NEOPLASMS; STANDARDS; TRENDS;

EID: 84903137437     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2014.916213     Document Type: Review
Times cited : (21)

References (18)
  • 2
    • 84903127033 scopus 로고    scopus 로고
    • Claims $1000 Genome GenomeWeb 2014. Available From: Last accessed 27 January 2014]
    • Winnick E. Illumina launches two new platforms at JP Morgan Conference; claims $1,000 genome. GenomeWeb 2014. Available from: Www.genomeweb.com/ sequencing/illumina-launches-Two-newplatforms-jp-morgan-conference-claims-1000- genome [Last accessed 27 January 2014]
    • Illumina Launches Two New Platforms At JP Morgan Conference
    • Winnick, E.1
  • 3
    • 84875217898 scopus 로고    scopus 로고
    • Disease-Targeted sequencing: A cornerstone in the clinic
    • Rehm HL. Disease-Targeted sequencing: A cornerstone in the clinic. Nat Rev Genet 2013;14:295-300
    • (2013) Nat Rev Genet , vol.14 , pp. 295-300
    • Rehm, H.L.1
  • 5
    • 84903284152 scopus 로고    scopus 로고
    • Assessing the necessity of confirmatory testing for exome-sequencing results in a clinical molecular diagnostics laboratory
    • Epub ahead to print]
    • Strom SP, Lee H, Das K, et al. Assessing the necessity of confirmatory testing for exome-sequencing results in a clinical molecular diagnostics laboratory. Genet Med 2014. [Epub ahead to print]
    • Genet Med 2014.
    • Strom, S.P.1    Lee, H.2    Das, K.3
  • 7
    • 84880240161 scopus 로고    scopus 로고
    • Next-generation sequencing. Reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer
    • Vignot S, Frampton GM, Soria JC, et al. Next-generation sequencing. reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer. J Clin Oncol 2013;31:2167-72
    • (2013) J Clin Oncol , vol.31 , pp. 2167-2172
    • Vignot, S.1    Frampton, G.M.2    Soria, J.C.3
  • 8
    • 84893962650 scopus 로고    scopus 로고
    • Tumor heterogeneity revealed by kras braf and pik3ca pyrosequencing: Kras and pik3ca intratumour mutation profile differences and their therapeutic implications
    • Kosmidou V, Oikonomou E, Vlassi M, et al. Tumor heterogeneity revealed by KRAS, BRAF, and PIK3CA pyrosequencing: KRAS and PIK3CA intratumour mutation profile differences and their therapeutic implications. Hum Mutat 2014;35(3): 329-40
    • (2014) Hum Mutat , vol.35 , Issue.3 , pp. 329-340
    • Kosmidou, V.1    Oikonomou, E.2    Vlassi, M.3
  • 9
    • 44449132629 scopus 로고    scopus 로고
    • Clinical utility of circulating tumor cells: A role for monitoring response to therapy and drug development
    • DOI 10.2217/17520363.2.2.137
    • Urtishak S, Alpaugh RK, Weiner LM, Swaby RF. Clinical utility of circulating tumor cells: A role for monitoring response to therapy and drug development. Biomark Med 2008;2(2):137-45 (Pubitemid 351753459)
    • (2008) Biomarkers in Medicine , vol.2 , Issue.2 , pp. 137-145
    • Urtishak, S.1    Alpaugh, R.K.2    Weiner, L.M.3    Swaby, R.F.4
  • 10
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • Dawson SJ, Rosenfeld N, Caldas C, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 2013;368:1199-209
    • (2013) N Engl J Med , vol.368 , pp. 1199-1209
    • Dawson, S.J.1    Rosenfeld, N.2    Caldas, C.3
  • 11
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network.
    • The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2013;487:330-7
    • (2013) Nature , vol.487 , pp. 330-337
  • 12
    • 65449144325 scopus 로고    scopus 로고
    • Evaluation of next generation sequencing platforms for population targeted sequencing studies
    • Harismendy O, Ng PC, Strausberg RL, et al. Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol 2009;10:R32
    • (2009) Genome Biol , vol.10
    • Harismendy, O.1    Ng, P.C.2    Strausberg, R.L.3
  • 13
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • DOI 10.1093/nar/gkg509
    • Ng PC, Henikoff S, SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 2003;31:3812-14 (Pubitemid 37442253)
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 14
    • 77951640946 scopus 로고    scopus 로고
    • A method and server for predicting damaging missense mutations
    • Adzhubei IA, Schmidt S, Peshkin L, et al. A method and server for predicting damaging missense mutations. Nat Methods 2010;7:248-9
    • (2010) Nat Methods , vol.7 , pp. 248-249
    • Adzhubei, I.A.1    Schmidt, S.2    Peshkin, L.3
  • 15
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-Associated genes
    • Lawrence MS, Stojanov P, Polak P, et al. Mutational heterogeneity in cancer and the search for new cancer-Associated genes. Nature 2013;499:214-18
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1    Stojanov, P.2    Polak, P.3
  • 16
    • 84881396090 scopus 로고    scopus 로고
    • Computational approaches to identify functional genetic variants in cancer genomes
    • Gonzalez-Perez A, Mustonen V, Reva B, et al. Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods 2013;10:723-9
    • (2013) Nat Methods , vol.10 , pp. 723-729
    • Gonzalez-Perez, A.1    Mustonen, V.2    Reva, B.3
  • 17
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis E, Watson IR, Kryukov GV, et al. A landscape of driver mutations in melanoma. Cell 2012;150:251-63
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.