Polymorphism of the cystatin C gene in patients with acute coronary syndromes: Results from the PLATelet inhibition and patient Outcomes study

American Heart Journal

Volumn 168, Issue 1, 2014, Pages

  Åkerblom, Axel ^a   Eriksson, Niclas ^a   Wallentin, Lars ^a   Siegbahn, Agneta ^a   Barratt, Bryan J ^b   Becker, Richard C ^c   Budaj, Andrzej ^d   Himmelmann, Anders ^e   Husted, Steen ^f   Storey, Robert F ^g   Johansson, Åsa ^a   James, Stefan K ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA   (United Kingdom)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d GROCHOWSKI HOSPITAL   (Poland)

^e ASTRAZENECA R AND D   (Sweden)

^f REGIONAL HOSPITAL WEST JUTLAND   (Denmark)

^g UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; CYSTATIN C; TICAGRELOR;

ACUTE CORONARY SYNDROME; ADULT; ALLELE; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; FEMALE; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUDDEN CARDIAC DEATH;

ACUTE CORONARY SYNDROME; AGED; CYSTATIN C; DNA; FEMALE; FOLLOW-UP STUDIES; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; POLYMORPHISM, GENETIC; TREATMENT OUTCOME;

EID: 84903132639     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2014.03.010     Document Type: Article

References (21)

1. J. Coresh, E. Selvin, and L.A. Stevens et al. Prevalence of chronic kidney disease in the United States JAMA 298 17 2007 2038 2047 (Pubitemid 350074801)
2. A.S. Go, G.M. Chertow, and D. Fan et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization N Engl J Med 351 13 2004 1296 1305
3. S. James, A. Budaj, and P. Aylward et al. Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial Circulation 122 11 2010 1056 1067
4. A.O. Grubb Cystatin C - properties and use as diagnostic marker Adv Clin Chem 35 2000 63 99
5. A. Kottgen, N.L. Glazer, and A. Dehghan et al. Multiple loci associated with indices of renal function and chronic kidney disease Nat Genet 41 6 2009 712 717
6. C.M. O'Seaghdha, A. Tin, and Q. Yang et al. Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality Am J Kidney Dis 63 1 2014 16 22
7. A. Akerblom, L. Wallentin, and A. Siegbahn et al. Cystatin C and estimated glomerular filtration rate as predictors for adverse outcome in patients with ST-elevation and non-ST-elevation acute coronary syndromes: results from the Platelet Inhibition and Patient Outcomes study Clin Chem 58 1 2012 190 199
8. F. Windhausen, A. Hirsch, and J. Fischer et al. Cystatin C for enhancement of risk stratification in non-ST elevation acute coronary syndrome patients with an increased troponin T Clin Chem 55 6 2009 1118 1125
9. P. Eriksson, H. Deguchi, and A. Samnegard et al. Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease Arterioscler Thromb Vasc Biol 24 3 2004 551 557 (Pubitemid 38326152)
10. S. James, A. Akerblom, and C.P. Cannon et al. Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial Am Heart J 157 4 2009 599 605
11. L. Wallentin, R.C. Becker, and A. Budaj et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 11 2009 1045 1057
12. K.L. Gunderson, F.J. Steemers, and G. Lee et al. A genome-wide scalable SNP genotyping assay using microarray technology Nat Genet 37 5 2005 549 554 (Pubitemid 40617286)
13. S. Purcell, B. Neale, and K. Todd-Brown et al. PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 3 2007 559 575 (Pubitemid 47330214)
14. A.S. Levey, L.A. Stevens, and C.H. Schmid et al. A new equation to estimate glomerular filtration rate Ann Intern Med 150 9 2009 604 612
15. A.L. Price, N.J. Patterson, and R.M. Plenge et al. Principal components analysis corrects for stratification in genome-wide association studies Nat Genet 38 8 2006 904 909 (Pubitemid 44141658)
16. S.A. Stanhope, and A.D. Skol Improved minimum cost and maximum power two stage genome-wide association study designs PLoS One 7 9 2012 e42367
17. M.J. Pencina, R.B. D'Agostino Sr., and R.B. D'Agostino Jr. et al. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond Stat Med 27 2 2008 157 172 [discussion 207-12] (Pubitemid 351193639)
18. L.A. Inker, C.H. Schmid, and H. Tighiouart et al. Estimating glomerular filtration rate from serum creatinine and cystatin C N Engl J Med 367 1 2012 20 29
19. A. Akerblom, L. Wallentin, and A. Larsson et al. Cystatin C- and creatinine-based estimates of renal function and their value for risk prediction in patients with acute coronary syndrome: results from the PLATelet Inhibition and Patient Outcomes (PLATO) Study Clin Chem 59 9 2013 1369 1375
20. M.G. Shlipak, M.D. Mattes, and C.A. Peralta Update on cystatin C: incorporation into clinical practice Am J Kidney Dis 62 3 2013 595 603
21. X.W. Cheng, G.P. Shi, and M. Kuzuya et al. Role for cysteine protease cathepsins in heart disease: focus on biology and mechanisms with clinical implication Circulation 125 12 2012 1551 1562