Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality

American Journal of Kidney Diseases

Volumn 63, Issue 1, 2014, Pages 16-22

  O'Seaghdha, Conall M ^a,b   Tin, Adrienne ^c   Yang, Qiong ^d   Katz, Ronit ^e   Liu, Yongmei ^f   Harris, Tamara ^g   Astor, Brad ^h   Coresh, Josef ⁱ   Fox, Caroline S ^a,j   Kao, W H Linda ^c   Shlipak, Michael G ^e  

^a FRAMINGHAM HEART STUDY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f WAKE FOREST SCHOOL OF MEDICINE   (United States)

^g NATIONAL INSTITUTE ON AGING   (United States)

^h UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY   (United States)

^j BRIGHAM AND WOMEN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYSTATIN C;

AGED; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; CONCENTRATION (PARAMETERS); CREATININE BLOOD LEVEL; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; GLOMERULUS FILTRATION RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

CHRONIC KIDNEY DISEASE; CYSTATIN C; GENETICS; NET RECLASSIFICATION IMPROVEMENT; SINGLE-NUCLEOTIDE POLYMORPHISM;

AGED; BIAS (EPIDEMIOLOGY); BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CREATININE; CYSTATIN C; FEMALE; GENETIC VARIATION; GLOMERULAR FILTRATION RATE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RENAL INSUFFICIENCY, CHRONIC; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; SURVIVAL RATE;

EID: 84896522335     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2013.06.015     Document Type: Article

References (23)

1. D.E. Weiner, H. Tighiouart, and M.G. Amin et al. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies J Am Soc Nephrol 15 5 2004 1307 1315
2. M.G. Shlipak, R. Katz, and M.J. Sarnak et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease Ann Intern Med 145 4 2006 237 246
3. creatinine Scand J Clin Lab Invest 72 1 2012 73 77
4. M.G. Shlipak, M.J. Sarnak, and R. Katz et al. Cystatin C and the risk of death and cardiovascular events among elderly persons N Engl J Med 352 20 2005 2049 2060
5. C.A. Peralta, M.G. Shlipak, and S. Judd et al. Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality JAMA 305 15 2011 1545 1552
6. KDIGO KDIGO Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease Kidney Int 3 1 2013
7. L.A. Inker, C.H. Schmid, and H. Tighiouart et al. Estimating glomerular filtration rate from serum creatinine and cystatin C N Engl J Med 367 1 2012 20 29
8. A. Kottgen, N.L. Glazer, and A. Dehghan et al. Multiple loci associated with indices of renal function and chronic kidney disease Nat Genet 41 6 2009 712 717
9. W.M. Brown, and K.M. Dziegielewska Friends and relations of the cystatin superfamily - new members and their evolution Protein Sci 6 1 1997 5 12
10. S.J. Hwang, Q. Yang, J.B. Meigs, E.N. Pearce, and C.S. Fox A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study BMC Med Genet 8 suppl 1 2007 S10
11. A. Kottgen, C. Pattaro, and C.A. Boger et al. New loci associated with kidney function and chronic kidney disease Nat Genet 42 5 2010 376 384
12. A.S. Levey, J.P. Bosch, J.B. Lewis, T. Greene, N. Rogers, and D. Roth A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group Ann Intern Med 130 6 1999 461 470
13. A.S. Levey, L.A. Stevens, and C.H. Schmid et al. A new equation to estimate glomerular filtration rate Ann Intern Med 150 9 2009 604 612
14. A.S. Levey, J. Coresh, and T. Greene et al. Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values Clin Chem 53 4 2007 766 772
15. L.A. Stevens, J. Coresh, and C.H. Schmid et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD Am J Kidney Dis 51 3 2008 395 406
16. M.J. Pencina, R.B. D'Agostino Sr., R.B. D'Agostino Jr., and R.S. Vasan Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond Stat Med 27 2 2008 157 172 discussion 207-212
17. W. Viechtbauer Conducting meta-analyses in R with the metafor package J Stat Softw 36 3 2010 1 48 http://www.jstatsoft.org/v36/i03/
18. N. Soranzo, S. Sanna, and E. Wheeler et al. Common variants at 10 genomic loci influence hemoglobin A(1)(C) levels via glycemic and nonglycemic pathways Diabetes 59 12 2010 3229 3239
19. C.M. O'Seaghdha, Q. Yang, H. Wu, S.J. Hwang, and C.S. Fox Performance of a genetic risk score for CKD stage 3 in the general population Am J Kidney Dis 59 1 2012 19 24
20. J.B. Meigs, P. Shrader, and L.M. Sullivan et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes N Engl J Med 359 21 2008 2208 2219
21. A. Tin, B.C. Astor, E. Boerwinkle, R.C. Hoogeveen, J. Coresh, and W.H. Kao Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin Hum Genet 132 6 2013 619 627
22. A. Tin, B.C. Astor, E. Boerwinkle, R.C. Hoogeveen, J. Coresh, and W.H. Kao Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans Nephrol Dial Transplant 28 6 2013 1497 1504
23. R. Xiao, and M. Boehnke Quantifying and correcting for the winner's curse in genetic association studies Genet Epidemiol 33 5 2009 453 462