Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer

Gynecologic Oncology

Volumn 134, Issue 1, 2014, Pages 121-128

  Qiu, Jun Jun ^a,b,c   Lin, Ying Ying ^d   Ye, Le Chi ^c   Ding, Jing Xin ^a,b,c   Feng, Wei Wei ^a,b,c   Jin, Hong Yan ^a,b,c   Zhang, Ying ^a,b,c   Li, Qing ^a,b,c   Hua, Ke Qin ^a,b,c  

^a OBSTETRICS AND GYNECOLOGY HOSPITAL OF FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

HOTAIR; Invasion; Metastasis; Ovarian cancer; Prognosis

Indexed keywords

COMPLEMENTARY RNA; HOX TRANSCRIPT ANTISENSE RNA; LONG UNTRANSLATED RNA; MATRIX METALLOPROTEINASE; UNCLASSIFIED DRUG; GELATINASE B; SMALL INTERFERING RNA; STROMELYSIN; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

ADULT; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; OVARIAN CANCER CELL LINE; OVARY CARCINOMA; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER GRADING; CANCER SURVIVAL; CORRELATIONAL STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC REGULATION; HISTOPATHOLOGY; HUMAN TISSUE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; REGULATORY MECHANISM; TUMOR INVASION;

HOTAIR; INVASION; METASTASIS; OVARIAN CANCER; PROGNOSIS;

ANIMALS; CELL LINE, TUMOR; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; PROGNOSIS; RNA, LONG NONCODING; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84903124951     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2014.03.556     Document Type: Article

References (33)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2011 69 90
2. R.C. Bast Jr., B. Hennessy, and G.B. Mills The biology of ovarian cancer: new opportunities for translation Nat Rev Cancer 9 2009 415 428
3. D.D. Bowtell The genesis and evolution of high-grade serous ovarian cancer Nat Rev Cancer 10 2010 803 808
4. G. Rustin, M. van der Burg, C. Griffin, W. Qian, and A.M. Swart Early versus delayed treatment of relapsed ovarian cancer Lancet 377 2011 380 381
5. J.E. Wilusz, H. Sunwoo, and D.L. Spector Long noncoding RNAs: functional surprises from the RNA world Genes Dev 23 2009 1494 1504
6. T. Nagano, and P. Fraser No-nonsense functions for long noncoding RNAs Cell 145 2011 178 181
7. I.J. Matouk, N. DeGroot, S. Mezan, S. Ayesh, R. Abu-lail, and A. Hochberg et al. The H19 non-coding RNA is essential for human tumor growth PLoS One 2 2007 e845
8. Y. Du, G. Kong, X. You, S. Zhang, T. Zhang, and Y. Gao et al. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18 J Biol Chem 287 2012 26302 26311
9. M. Huarte, M. Guttman, D. Feldser, M. Garber, M.J. Koziol, and D. Kenzelmann-Broz et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response Cell 142 2010 409 419
10. Y. Zhou, X. Zhang, and A. Klibanski MEG3 noncoding RNA: a tumor suppressor J Mol Endocrinol 48 2012 R45 R53
11. R. Lin, S. Maeda, C. Liu, M. Karin, and T.S. Edgington A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas Oncogene 26 2007 851 858
12. E. Pasmant, A. Sabbagh, J. Masliah-Planchon, N. Ortonne, I. Laurendeau, and L. Melin et al. Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1 J Natl Cancer Inst 103 2011 1713 1722
13. J.L. Rinn, M. Kertesz, J.K. Wang, S.L. Squazzo, X. Xu, and S.A. Brugmann et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs Cell 129 2007 1311 1323 (Pubitemid 46962090)
14. R.A. Gupta, N. Shah, K.C. Wang, J. Kim, H.M. Horlings, and D.J. Wong et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis Nature 464 2010 1071 1076
15. Z. Yang, L. Zhou, L.M. Wu, M.C. Lai, H.Y. Xie, and F. Zhang et al. Overexpression of long noncoding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation Ann Surg Oncol 18 2011 1243 1250
16. R. Kogo, T. Shimamura, K. Mimori, K. Kawahara, S. Imoto, and T. Sudo et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers Cancer Res 71 2011 6320 6326
17. K. Kim, I. Jutooru, G. Chadalapaka, G. Johnson, J. Frank, and R. Burghardt et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer Oncogene 32 2013 1616 1625
18. T. Niinuma, H. Suzuki, M. Nojima, K. Nosho, H. Yamamoto, and H. Takamaru et al. Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors Cancer Res 72 2012 1126 1136
19. L. Cui, X.Y. Xie, H. Wang, X.L. Chen, S.L. Liu, and L.N. Hu Expression of long non-coding RNA HOTAIR mRNA in ovarian cancer Sichuan Da Xue Xue Bao Yi Xue Ban 44 2013 57 59
20. D. Yu, J.K. Wolf, M. Scanlon, J.E. Price, and M.C. Hung Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A Cancer Res 53 1993 891 898 (Pubitemid 23077880)
21. F. Bai, J. Feng, Y. Cheng, J. Shi, R. Yang, and H. Cui Analysis of gene expression patterns of ovarian cancer cell lines with different metastatic potentials Int J Gynecol Cancer 16 2006 202 209
22. Y. Wang, L. Dong, H. Cui, D.H. Shen, Y. Wang, and X.H. Chang et al. Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior J Zhejiang Univ Sci B 12 2011 346 356
23. X. Shenhua, Q. Lijuan, N. Hanzhou, N. Xinghao, Z. Chihong, and Z. Gu et al. Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization J Exp Clin Cancer Res 18 1999 233 239 (Pubitemid 29359410)
24. W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells PLoS One 7 2012 e46609
25. S. Boissier, M. Ferreras, O. Peyruchaud, S. Magnetto, F.H. Ebetino, and M. Colombel et al. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases Cancer Res 60 2000 2949 2954 (Pubitemid 30395820)
26. D. Liu, H. Guo, Y. Li, X. Xu, K. Yang, and Y. Bai Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis PLoS One 7 2012 e31251
27. M. Zhang, C. Dai, H. Zhu, S. Chen, Y. Wu, and Q. Li et al. Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9 Mol Cell Biochem 357 2011 387 395
28. L. Ying, Q. Chen, Y. Wang, Z. Zhou, Y. Huang, and F. Qiu Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition Mol Biosyst 8 2012 2289 2294
29. K. Tano, R. Mizuno, T. Okada, R. Rakwal, J. Shibato, and Y. Masuo et al. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes FEBS Lett 584 2010 4575 4580
30. A. Iacoangeli, Y. Lin, E.J. Morley, I.A. Muslimov, R. Bianchi, and J. Reilly et al. BC200 RNA in invasive and preinvasive breast cancer Carcinogenesis 25 2004 2125 2133 (Pubitemid 39534849)
31. M.J. Bussemakers, A. van Bokhoven, G.W. Verhaegh, F.P. Smit, H.F. Karthaus, and J.A. Schalken et al. DD3: a new prostate-specific gene, highly overexpressed in prostate cancer Cancer Res 9 1999 5975 5979 (Pubitemid 30004960)
32. V. Srikantan, Z. Zou, G. Petrovics, L. Xu, M. Augustus, and L. Davis et al. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer Proc Natl Acad Sci U S A 97 2000 12216 12221
33. T. Gutschner, M. Hämmerle, and S. Diederichs MALAT1 - a paradigm for long noncoding RNA function in cancer J Mol Med (Berl) 91 2013 791 801