Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease

Brain Pathology

Volumn 24, Issue 4, 2014, Pages 344-351

  Hales, Chadwick M ^a   Dammer, Eric B ^a   Diner, Ian ^a   Yi, Hong ^b   Seyfried, Nicholas T ^a   Gearing, Marla ^a   Glass, Jonathan D ^a   Montine, Thomas J ^c   Levey, Allan I ^a   Lah, James J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

2,2,7 trimethylguanosine; ALS; Alzheimer's disease; quantitative PCR; RNA spliceosome; snRNA

Indexed keywords

RNA 18S; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; TAU PROTEIN; MAPT PROTEIN, HUMAN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GENE LOCATION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLE; PAIRED HELICAL FILAMENT; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA HYBRIDIZATION; SPLICEOSOME; TAUOPATHY; TRANSMISSION ELECTRON MICROSCOPY; BRAIN; CYTOPLASM; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MIDDLE AGED; SPINAL CORD; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; CYTOPLASM; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NEUROFIBRILLARY TANGLES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL NUCLEAR; SPINAL CORD; TAU PROTEINS; TAUOPATHIES;

EID: 84902779542     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12133     Document Type: Article

References (25)

1. Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, et al. (2013) U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci U S A 110: 16562-16567.
2. Bossers K, Wirz KT, Meerhoff GF, Essing AH, van Dongen JW, Houba P, et al. (2010) Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease. Brain 133 (Pt 12): 3699-3723.
3. van der Feltz C, Anthony K, Brilot A, Pomeranz Krummel DA, (2012) Architecture of the spliceosome. Biochemistry 51: 3321-3333.
4. Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, et al. (2003) Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. J Neurosci 23: 9697-9709.
5. Ginsberg SD, Crino PB, Lee VM, Eberwine JH, Trojanowski JQ, (1997) Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques. Ann Neurol 41: 200-209.
6. Gozal YM, Dammer EB, Duong DM, Cheng D, Gearing M, Rees HD, et al. (2011) Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology. Front Neurol 2: 24.
7. Gozal YM, Duong DM, Gearing M, Cheng D, Hanfelt JJ, Funderburk C, et al. (2009) Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease. J Proteome Res 8: 5069-5079.
8. Gozal YM, Seyfried NT, Gearing M, Glass JD, Heilman CJ, Wuu J, et al. (2011) Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration. Mol Neurodegener 6: 82.
9. Hanson KA, Kim SH, Tibbetts RS, (2012) RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond. Wiley Interdiscip Rev RNA 3: 265-285.
10. Kampers T, Friedhoff P, Biernat J, Mandelkow EM, Mandelkow E, (1996) RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments. FEBS Lett 399: 344-349.
11. Krainer AR, (1988) Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. Nucleic Acids Res 16: 9415-9429.
12. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
13. Lukiw WJ, (2007) Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18: 297-300.
14. Mills JD, Janitz M, (2012) Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases. Neurobiol Aging 33: 1012.e11-1012.e24.
15. Mills JD, Nalpathamkalam T, Jacobs HI, Janitz C, Merico D, Hu P, Janitz M, (2013) RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism. Neurosci Lett 536: 90-95.
16. Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA, (1999) RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 19: 1959-1964.
17. Ritchie DB, Schellenberg MJ, MacMillan AM, (2009) Spliceosome structure: piece by piece. Biochim Biophys Acta 1789: 624-633.
18. Ross CA, Poirier MA, (2004) Protein aggregation and neurodegenerative disease. Nat Med (Suppl. 10): S10-S17.
19. Spillantini MG, Goedert M, (1998) Tau protein pathology in neurodegenerative diseases. Trends Neurosci 21: 428-433.
20. Strasser A, Dickmanns A, Luhrmann R, Ficner R, (2005) Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J 24: 2235-2243.
21. Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, et al. (2013) Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med 5: 221-234.
22. Vanderweyde T, Youmans K, Liu-Yesucevitz L, Wolozin B, (2013) Role of stress granules and RNA-binding proteins in neurodegeneration: a mini-review. Gerontology 59: 524-533.
23. Wahl MC, Will CL, Luhrmann R, (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136: 701-718.
24. Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, et al. (2008) The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28: 1213-1223.
25. Yi H, Leunissen J, Shi G, Gutekunst C, Hersch S, (2001) A novel procedure for pre-embedding double immunogold-silver labeling at the ultrastructural level. J Histochem Cytochem 49: 279-284.