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Volumn 306, Issue 12, 2014, Pages

Acylcarnitines activate proinflammatory signaling pathways

Author keywords

Acylcarnitine; Inflammation; Pattern recognition receptors; TLR; oxidation

Indexed keywords

ACYLCARNITINE; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

EID: 84902687761     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00656.2013     Document Type: Article
Times cited : (225)

References (25)
  • 1
    • 66749094133 scopus 로고    scopus 로고
    • Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women
    • Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, Minkler PE, Hwang DH, Newman JW, Garvey WT. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 139: 1073-1081, 2009.
    • (2009) J Nutr , vol.139 , pp. 1073-1081
    • Adams, S.H.1    Hoppel, C.L.2    Lok, K.H.3    Zhao, L.4    Wong, S.W.5    Minkler, P.E.6    Hwang, D.H.7    Newman, J.W.8    Garvey, W.T.9
  • 4
    • 0036739173 scopus 로고    scopus 로고
    • Interactions of acyl carnitines with model membranes: A (13)C-NMR study
    • Ho JK, Duclos RI Jr, Hamilton JA. Interactions of acyl carnitines with model membranes: a (13)C-NMR study. J Lipid Res 43: 1429-1439, 2002.
    • (2002) J Lipid Res , vol.43 , pp. 1429-1439
    • Ho, J.K.1    Duclos Jr., R.I.2    Hamilton, J.A.3
  • 8
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276: 16683-16689, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 9
    • 2342435824 scopus 로고    scopus 로고
    • Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    • Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, Lee WH, Fitzgerald KA, Hwang DH. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem 279: 16971-16979, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 16971-16979
    • Lee, J.Y.1    Zhao, L.2    Youn, H.S.3    Weatherill, A.R.4    Tapping, R.5    Feng, L.6    Lee, W.H.7    Fitzgerald, K.A.8    Hwang, D.H.9
  • 10
    • 0027076645 scopus 로고
    • Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide
    • Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267: 25934-25938, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 25934-25938
    • Lee, S.H.1    Soyoola, E.2    Chanmugam, P.3    Hart, S.4    Sun, W.5    Zhong, H.6    Liou, S.7    Simmons, D.8    Hwang, D.9
  • 11
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2: 725-734, 2002.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 13
    • 0037604765 scopus 로고    scopus 로고
    • Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes
    • Mizel SB, Honko AN, Moors MA, Smith PS, West AP. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J Immunol 170: 6217-6223, 2003.
    • (2003) J Immunol , vol.170 , pp. 6217-6223
    • Mizel, S.B.1    Honko, A.N.2    Moors, M.A.3    Smith, P.S.4    West, A.P.5
  • 16
    • 2542593338 scopus 로고    scopus 로고
    • Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
    • Schrauwen P, Hesselink MK. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 53: 1412-1417, 2004.
    • (2004) Diabetes , vol.53 , pp. 1412-1417
    • Schrauwen, P.1    Hesselink, M.K.2
  • 17
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitateinduced insulin resistance in myotubes
    • Senn JJ. Toll-like receptor-2 is essential for the development of palmitateinduced insulin resistance in myotubes. J Biol Chem 281: 26865-26875, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 18
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-136, 2002.
    • (2002) Nat Cell Biol , vol.4
    • Shaulian, E.1    Karin, M.2
  • 20
    • 4744344777 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B
    • Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 279: 41294-41301, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 41294-41301
    • Sinha, S.1    Perdomo, G.2    Brown, N.F.3    O'Doherty, R.M.4
  • 21
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45: 42-72, 2006.
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 22
    • 0035661498 scopus 로고    scopus 로고
    • Influence of dietary supplementation with longchain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults
    • Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA, Calder PC. Influence of dietary supplementation with longchain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids 36: 1183-1193, 2001.
    • (2001) Lipids , vol.36 , pp. 1183-1193
    • Thies, F.1    Miles, E.A.2    Nebe-von-Caron, G.3    Powell, J.R.4    Hurst, T.L.5    Newsholme, E.A.6    Calder, P.C.7
  • 23
    • 41649093318 scopus 로고    scopus 로고
    • Inflammatory mechanisms in the regulation of insulin resistance
    • Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 14: 222-231, 2008.
    • (2008) Mol Med , vol.14 , pp. 222-231
    • Tilg, H.1    Moschen, A.R.2
  • 24
    • 70350482557 scopus 로고    scopus 로고
    • Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
    • Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH. Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem 284: 27384-27392, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 27384-27392
    • Wong, S.W.1    Kwon, M.J.2    Choi, A.M.3    Kim, H.P.4    Nakahira, K.5    Hwang, D.H.6
  • 25
    • 0014901610 scopus 로고
    • Some micellar properties of long-chain acylcarnitines
    • Yalkowsky SH, Zografi G. Some micellar properties of long-chain acylcarnitines. J Colloid Interface Sci 34: 525-533, 1970.
    • (1970) J Colloid Interface Sci , vol.34 , pp. 525-533
    • Yalkowsky, S.H.1    Zografi, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.