A recipe for pluripotency: The correct sp(l)ices make all the difference. Focus on "Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency"

American Journal of Physiology - Cell Physiology

Volumn 306, Issue 12, 2014, Pages

  Gokhale, Paul J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 5; NERVE CELL ADHESION MOLECULE; OCT4A PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

CELL CLONING; CELL DIFFERENTIATION; CELL RENEWAL; EDITORIAL; EMBRYONIC STEM CELL; ENDODERM; HUMAN; NEUROECTODERM; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; UPREGULATION;

ANIMALS; CLONE CELLS; EMBRYONIC STEM CELLS; HUMANS; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN ISOFORMS;

EID: 84902668888     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00116.2014     Document Type: Editorial

References (12)

1. Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI. Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells. Stem Cells Dev 22: 1136-1146, 2013.
2. Cauffman G, Liebaers I, Van Steirteghem A, Van de Velde H. POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos. Stem Cells 24: 2685-2691, 2006.
3. Enver T, Pera M, Peterson C, Andrews PW. Stem cell states, fates, and the rules of attraction. Cell Stem Cell 8: 387-397, 2009.
4. Mallanna SK, Rizzino A. Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells. J Cell Physiol 227: 27-34, 2012.
5. Nichols J, Smith A. Naive and primed pluripotent states. Cell Stem Cell 4: 487-492, 2009.
6. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-376, 2000.
7. Pera MF, Tam PP. Extrinsic regulation of pluripotent stem cells. Nature 465: 713-720, 2010.
8. Radzisheuskaya A, Chia Gle B, dos Santos RL, Theunissen TW, Castro LF, Nichols J, Silva JC. A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nat Cell Biol 15: 579-590, 2013.
9. Tsai SC, Chang DF, Hong CM, Xia P, Senadheera D, Trump L, Mishra S, Lutzko C. Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency. Am J Physiol Cell Physiol (March 13, 2014). doi:10.1152/ajpcell.00205.2013.
10. Wang X, Dai J. Isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells 28: 885-893, 2010.
11. Wang Z, Oron E, Nelson B, Razis S, Ivanova N. Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10: 440-454, 2012.
12. Wu CS, Yu CY, Chuang CY, Hsiao M, Kao CF, Kuo HC, Chuang TJ. Integrative transcriptome sequencing identifies trans-splicing events with important roles in human embryonic stem cell pluripotency. Genome Res 24: 25-36, 2014.