Plastic induction of CD133AC133-positive cells in the microenvironment of glioblastoma spheroids

International Journal of Oncology

Volumn 45, Issue 2, 2014, Pages 581-586

  Ohnishi, Ken ^a   Tani, Toshiaki ^a   Bando, Shin Ichi ^a   Kubota, Nobuo ^a   Fujii, Yoshihiro ^a   Hatano, Osamu ^b   Harada, Hirosi ^c  

^a IBARAKI PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Cancer stem cell; CD133; Glioblastoma; Spheroid

Indexed keywords

CD133 AC133 ANTIGEN; CD133 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NESTIN; PLASTIC; UNCLASSIFIED DRUG; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE;

ARTICLE; FROZEN SECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PHENOTYPE; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR MICROENVIRONMENT; TUMOR MODEL; TUMOR SPHEROID; CANCER STEM CELL; CELL HYPOXIA; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANTIGENS, CD; CELL HYPOXIA; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; NEOPLASTIC STEM CELLS; PEPTIDES; REAL-TIME POLYMERASE CHAIN REACTION; SPHEROIDS, CELLULAR; TRANSFECTION; TUMOR MICROENVIRONMENT;

EID: 84902580888     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2483     Document Type: Article

References (29)

1. Bao S, Wu Q, McLendon RE, Hao Y, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760, 2006. (Pubitemid 44949604)
2. Mannino M and Chalmers AJ: Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit'? Mol Oncol 5: 374-386, 2011.
3. + cancer stem cells in glioblastoma. Mol Cancer 5: 67, 2006.
4. Kang MK and Kang SK: Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. Stem Cells Dev 16: 837-847, 2007.
5. Mohyeldin A, Garzón-Muvdi T and Quiñones-Hinojosa A: Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7: 150-161, 2010.
6. Parmar K, Mauch P, Vergilio JA, et al: Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci USA 104: 5431-5436, 2007. (Pubitemid 47175697)
7. Heddleston JM, Li Z, McLendon RE, et al: The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 8: 3274-3284, 2009.
8. Mao XG, Yan M, Xue XY, et al: Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors. Lab Invest 91: 1068-1078, 2011.
9. Soeda A, Park M, Lee D, et al: Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene 28: 3949-3959, 2009.
10. Bar EE, Lin A, Mahairaki V, et al: Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol 177: 1491-1502, 2010.
11. Kolenda J, Jensen SS, Aaberg-Jessen C, et al: Effects of hypoxia on expression of a panel of stem cell and chemoresistance markers in glioblastoma-derived spheroids. J Neurooncol 103: 43-58, 2011.
12. Iida H, Suzuki M, Goitsuka R, et al: Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2. Int J Oncol 40: 71-79, 2012.
13. Mathieu J, Zhang Z, Zhou W, et al: HIF induces human embryonic stem cell markers in cancer cells. Cancer Res 71: 4640-4652, 2011.
14. Monzani E, Facchetti F, Galmozzi E, et al: Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. Eur J Cancer 43: 935-946, 2007. (Pubitemid 46366698)
15. O'Brien C A, Pollett A, Gallinger S, et al: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110, 2007. (Pubitemid 46067310)
16. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al: Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115, 2007. (Pubitemid 46067311)
17. Ma S, Chan KW, Hu L, et al: Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 132: 2542-2556, 2007. (Pubitemid 46890873)
18. Tirino V, Desiderio V, Paino F, et al: Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo. FASEB J 25: 2022-2030, 2011.
19. Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004. (Pubitemid 39551674)
20. Beier D, Hau P, Proescholdt M, et al: CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67: 4010-4015, 2007. (Pubitemid 46815044)
21. Joo KM, Kim SY, Jin X, et al: Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Invest 88: 808-815, 2008.
22. - tumor-initiating cells in adult human gliomas. Neurosurgery 62: 505-514, 2008.
23. Wang J, Sakariassen P, Tsinkalovsky O, et al: CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer 122: 761-768, 2008.
24. Platet N, Liu SY, Atifi ME, et al: Influence of oxygen tension on CD133 phenotype in human glioma cell cultures. Cancer Lett 258: 286-290, 2007. (Pubitemid 350110377)
25. Yang Z, Wang Z, Fan Y, et al: Expression of CD133 in SW620 colorectal cancer cells is modulated by the microenvironment. Oncol Lett 4: 75-79, 2012.
26. Sutherland RM: Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240: 177-184, 1988.
27. Freyer JP, Tustanoff E, Franko AJ, et al: In situ oxygen consumption rates of cells in V-79 multicellular spheroids during growth. J Cell Physiol 118: 53-61, 1984. (Pubitemid 14184343)
28. Freyer JP and Sutherland RM: A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth. J Cell Physiol 124: 516-524, 1985. (Pubitemid 16242762)
29. Kemper K, Sprick MR, de Bree M, et al: The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res 70: 719-729, 2010.