Identification of a genetic variant at 2q12.1 associated with blood pressure in East-Asians by genome-wide scan including gene-environment interactions

BMC Medical Genetics

Volumn 15, Issue 1, 2014, Pages

  Kim, Yun K ^a,b   Kim, Youngdoe ^a   Hwang, Mi Y ^a   Shimokawa, Kazuro ^c   Won, Sungho ^d   Kato, Norihiro ^c   Tabara, Yasuharu ^e   Yokota, Mitsuhiro ^f   Han, Bok Ghee ^a   Lee, Jong H ^b   Kim, Bong Jo ^a  

^a Korea Centers for Disease Control and Prevention   (South Korea)

^b Yonsei University   (South Korea)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^d Chung Ang University   (South Korea)

^e KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Blood pressure; Gene environment interaction; Genome wide scan; Meta analysis; Obesity

Indexed keywords

MEMBRANE PROTEIN; TMEM182 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; ASIAN; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHROMOSOME 2Q; DIASTOLIC BLOOD PRESSURE; EFFECT SIZE; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; WAIST HIP RATIO;

ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; BODY MASS INDEX; CHROMOSOMES, HUMAN, PAIR 2; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84902547371     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-15-65     Document Type: Article

References (30)

1. Whitworth JA. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003, 21(11):1983-1992.
2. Wadei HM, Textor SC. The role of the kidney in regulating arterial blood pressure. Nat Rev Nephrol 2012, 8(10):602-609. 10.1038/nrneph.2012.191, 22926246.
3. Padmanabhan S, Newton-Cheh C, Dominiczak AF. Genetic basis of blood pressure and hypertension. Trends Genet 2012, 28(8):397-408. 10.1016/j.tig.2012.04.001, 22622230.
4. Staessen JA, Wang J, Bianchi G, Birkenhager WH. Essential hypertension. Lancet 2003, 361(9369):1629-1641. 10.1016/S0140-6736(03)13302-8, 12747893.
5. Hottenga JJ, Boomsma DI, Kupper N, Posthuma D, Snieder H, Willemsen G, de Geus EJ. Heritability and stability of resting blood pressure. Twin Res Hum Genet 2005, 8(5):499-508. 10.1375/twin.8.5.499, 16212839.
6. Kupper N, Willemsen G, Riese H, Posthuma D, Boomsma DI, de Geus EJ. Heritability of daytime ambulatory blood pressure in an extended twin design. Hypertension 2005, 45(1):80-85. 10.1161/01.HYP.0000149952.84391.54, 15557390.
7. Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011, 478(7367):103-109. 10.1038/nature10405, 3340926, 21909115.
8. Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson JE, Chen YT, Miki T, Zhou X. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet 2011, 43(6):531-538. 10.1038/ng.834, 3158568, 21572416.
9. Adeyemo A, Gerry N, Chen G, Herbert A, Doumatey A, Huang H, Zhou J, Lashley K, Chen Y, Christman M, Rotimi C. A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 2009, 5(7):e1000564. 10.1371/journal.pgen.1000564, 2702100, 19609347.
10. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009, 41(6):666-676. 10.1038/ng.361, 2891673, 19430483.
11. Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, Cha SH, Kim JW, Han BG, Min H, Ahn Y, Park MS, Han HR, Jang HY, Cho EY, Lee JE, Cho NH, Shin C, Park T, Park JW, Lee JK, Cardon L, Clarke G, McCarthy MI, Lee JY, Lee JK. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 2009, 41(5):527-534. 10.1038/ng.357, 19396169.
12. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009, 461(7265):747-753. 10.1038/nature08494, 2831613, 19812666.
13. Eichler EE, Flint J, Gibson G, Kong A, Leal SM, Moore JH, Nadeau JH. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet 2010, 11(6):446-450. 10.1038/nrg2809, 2942068, 20479774.
14. Pausova Z, Tremblay J, Hamet P. Gene-environment interactions in hypertension. Curr Hypertens Rep 1999, 1(1):42-50. 10.1007/s11906-999-0072-z, 10981041.
15. Pausova Z. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens 2006, 15(2):173-178. 10.1097/01.mnh.0000214775.42103.a5, 16481885.
16. Taylor JY, Sun YV, Hunt SC, Kardia SL. Gene-environment interaction for hypertension among African American women across generations. Biol Res Nurs 2010, 12(2):149-155. 10.1177/1099800410371225, 3005771, 20591971.
17. Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi F, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. Hypertens Res 2009, 32(3):207-213. 10.1038/hr.2009.3, 19262484.
18. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 2009, 41(1):35-46. 10.1038/ng.271, 2687077, 19060910.
19. Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, Hwang JY, Oh JH, Kim DJ, Kim NH, Kim S, Hong EJ, Kim JH, Min H, Kim Y, Zhang R, Jia W, Okada Y, Takahashi A, Kubo M, Tanaka T, Kamatani N, Matsuda K, Park T, Oh B, Kimm K, Kang D, Shin C, Cho NH, . MAGIC consortium Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet 2011, 43(10):990-995. 10.1038/ng.939, 21909109, MAGIC consortium.
20. Marchini J, Howie B, Myers S, McVean G, Donnelly P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 2007, 39(7):906-913. 10.1038/ng2088, 17572673.
21. Moskvina V, Schmidt KM. On multiple-testing correction in genome-wide association studies. Genet Epidemiol 2008, 32(6):567-573. 10.1002/gepi.20331, 18425821.
22. Pe'er I, Yelensky R, Altshuler D, Daly MJ. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 2008, 32(4):381-385. 10.1002/gepi.20303, 18348202.
23. Wu Y, Smas CM. Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage. BMC Res Notes 2008, 1:85. 10.1186/1756-0500-1-85, 2564950, 18803820.
24. Shi D, Funayama T, Mashima Y, Takano Y, Shimizu A, Yamamoto K, Mengkegale M, Miyazawa A, Yasuda N, Fukuchi T, Abe H, Ideta H, Nishida K, Nakazawa T, Richards JE, Fuse N. Association of HK2 and NCK2 with normal tension glaucoma in the Japanese population. PLoS One 2013, 8(1):e54115. 10.1371/journal.pone.0054115, 3551945, 23349798.
25. Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HF. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3 T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes 2002, 51(5):1319-1336. 10.2337/diabetes.51.5.1319, 11978627.
26. Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology 2004, 145(5):2214-2220. 10.1210/en.2003-1580, 14764635.
27. Jin HS, Hong KW, Kim BY, Kim J, Yoo YH, Oh B, Jeong SY. Replicated association between genetic variation in the PARK2 gene and blood pressure. Clin Chim Acta 2011, 412(17-18):1673-1677.
28. Jin HS, Sober S, Hong KW, Org E, Kim BY, Laan M, Oh B, Jeong SY. Age-dependent association of the polymorphisms in the mitochondria-shaping gene, OPA1, with blood pressure and hypertension in Korean population. Am J Hypertens 2011, 24(10):1127-1135. 10.1038/ajh.2011.131, 21796221.
29. Hong KW, Go MJ, Jin HS, Lim JE, Lee JY, Han BG, Hwang SY, Lee SH, Park HK, Cho YS, Oh B. Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts. J Hum Hypertens 2010, 24(6):367-372. 10.1038/jhh.2009.86, 19960030.
30. Hong KW, Jin HS, Lim JE, Kim S, Go MJ, Oh B. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. J Hum Genet 2010, 55(6):336-341. 10.1038/jhg.2010.31, 20414254.