Clinical and cognitive risk factors for psychotic symptoms in 22q11.2 deletion syndrome: A transversal and longitudinal approach

European Child and Adolescent Psychiatry

Volumn 23, Issue 6, 2014, Pages 425-436

  Schneider, Maude ^a   Schaer, Marie ^a,b   Mutlu, A Kadir ^a   Menghetti, Sarah ^a   Glaser, Bronwyn ^a   Debbané, Martin ^a,c   Eliez, Stephan ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

22q11DS; Hallucinations; Mixed models; Negative symptoms; Positive psychotic symptoms; Schizophrenia

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; METHYLPHENIDATE; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT;

ADOLESCENT; ADULT; ANTICONVULSANT THERAPY; ARTICLE; CHILD; CHROMOSOME DELETION 22Q11; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DELUSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GROUPS BY AGE; HALLUCINATION; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; NEGATIVE SYNDROME; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; POSITIVE SYNDROME; PSYCHOSIS; RISK FACTOR; SCHIZOPHRENIA; SYMPTOM;

ADOLESCENT; ADULT; CHILD; COGNITION; CROSS-SECTIONAL STUDIES; DELUSIONS; DIGEORGE SYNDROME; FEMALE; HALLUCINATIONS; HUMANS; LONGITUDINAL STUDIES; MALE; PSYCHOTIC DISORDERS; RISK FACTORS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84902547355     PISSN: 10188827     EISSN: 1435165X     Source Type: Journal    
DOI: 10.1007/s00787-013-0469-8     Document Type: Article

References (41)

1. Murphy K, Jones L, Owen M (1999) High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 56(10):940-945
2. WHO (1996) Schizophrenia and public health. Nations for mental health
3. DebbanéM, Glaser B, David MK, Feinstein C, Eliez S (2006) Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: neuropsychological and behavioral implications. Schizophr Res 84(2-3):187-193
4. Gothelf D, Feinstein C, Thompson T, Gu E, Penniman L, Van Stone E, Kwon H, Eliez S, Reiss AL (2007) Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome. Am J Psych 164(4):663-669
5. Armando M, Girardi P, Vicari S, Menghini D, Digilio MC, Pontillo M, Saba R, Mazzone L, Lin A, Klier CM, Schäfer MR, Amminger GP (2012) Adolescents at ultra-high risk for psychosis with and without 22q11 deletion syndrome: a comparison of prodromal psychotic symptoms and general functioning. Schizophr Res 139(1-3):151-156
6. Schneider M, Van der Linden M, Glaser B, Rizzi E, Dahoun SP, Hinard C, Bartoloni L, Antonarakis SE, DebbanéM, Eliez S (2012) Preliminary structure and predictive value of attenuated negative symptoms in 22q11.2 deletion syndrome. Psychiat Res 196:277-284
7. Lucas S, Fitzgerald D, Redoblado-Hodge MA, Anderson J, Sanbrook M, Harris A, Brennan J (2004) Neuropsychological correlates of symptom profiles in first episode schizophrenia. Schizophr Res 71(2-3):323-330
8. Rhinewine JP, Lencz T, Thaden EP, Cervellione KL, Burdick KE, Henderson I, Bhaskar S, Keehlisen L, Kane J, Kohn N, Fisch GS, Bilder RM, Kumra S (2005) Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biol Psychiatry 58(9):705-712
9. Becker HE, Nieman DH, Wiltink S, Dingemans PM, van de Fliert JR, Velthorst E, de Haan L, van Amelsvoort TA, Linszen DH (2010) Neurocognitive functioning before and after the first psychotic episode: does psychosis result in cognitive deterioration? Psychol Med 40(10):1599-1606
10. Keefe RSE, Perkins DO, Gu H, Zipursky RB, Christensen BK, Lieberman JA (2006) A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophr Res 88(1-3):26-35
11. Lencz T, Smith CW, McLaughlin D, Auther A, Nakayama E, Hovey L, Cornblatt BA (2006) Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol Psychiatry 59(9):863-871
12. Frommann I, Pukrop R, Brinkmeyer J, Bechdolf A, Ruhrmann S, Berning J, Decker P, Riedel M, Möller H-J, Wölwer W, Gaebel W, Klosterkötter J, Maier W, Wagner M (2011) Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early- and additional memory dysfunction in the late-prodromal state. Schizophr Bull 37(4): 861-873
13. Antshel KM, Shprintzen R, Fremont W, Higgins AM, Faraone SV, Kates WR (2010) Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up study. J Am Acad Child Adolesc Psychiatry 49(4):333-344
14. Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, Kwon H, Jin S, Jo B, Antonarakis SE, Morris MA, Reiss AL (2005) COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nat Neurosci 8(11):1500-1502
15. Green T, Gothelf D, Glaser B, Debbane M, Frisch A, Kotler M, Weizman A, Eliez S (2009) Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome. J Am Acad Child Adolesc Psychiatry 48(11): 1060-1068
16. Shapiro DI, Cubells JF, Ousley OY, Rockers K, Walker EF (2011) Prodromal symptoms in adolescents with 22q11.2 deletion syndrome and schizotypal personality disorder. Schizophr Res 129(1):20-28
17. Schaer M, DebbanéM, Bach Cuadra M, Ottet M-C, Glaser B, Thiran J-P, Eliez S (2009) Deviant trajectories of cortical maturation in 22q11.2 deletion syndrome (22q11DS): a cross-sectional and longitudinal study. Schizophr Res 115(2-3):182-190
18. Reich W (2000) Diagnostic interview for children and adolescents (DICA). J Am Acad Child Adolesc Psychiatry 39:59-66
19. First M, Spitzer R, Gibbon M, Williams J (1996) Structured clinical interview for the DSM-IV-TR axis I disorders (SCID-I). Biometrics Research, New York State Psychiatric Institute, New York
20. Kaufman J, Birmaher B, Brent D, Rao U (1997) Schedule for affective disorders and schizophrenia for school-Age childrenpresent lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980-988
21. McGlashan TH, Miller TJ, Woods SW (2001) Structured Interview for Prodromal Syndromes (SIPS; Version 3.0, unpublished manuscript). PRIME Research Clinic, Yale University, School of Medicine, New Heaven, Connecticut
22. Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, Ventura J, McFarlane W, Perkins DO, Pearlson GD, Woods SW (2003) Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29(4):703-715
23. Overall J, Gorham D (1962) The brief psychiatric rating scale. Psychol Rep 10:799-812
24. Nicholson IR, Chapman JE, Neufeld RW (1995) Variability in BPRS definitions of positive and negative symptoms. Schizophr Res 17(2):177-185
25. Wechsler D (1991) Wechsler Intelligence Scale for Children, 3rd edn. Manual. The Psychological Corporation, San Antonio
26. Cohen M (1997) Children's memory scale. The Psychological Corporation, London
27. Wechsler D (1997) Wechsler Adult Intelligence Scale, 3rd edn. Administration and scoring manual. The Psychological Corporation, San Antonio
28. Wechsler D (1987) Manual for the Wechsler Memory Scale-revised. The Psychological Corporation, San Antonio
29. Dedrick RF, Ferron JM, Hess MR, Hogarty KY, Kromrey JD, Lang TR, Niles JD, Lee RS (2009) Multilevel modeling: a review of methodological issues and applications. Rev Educ Res 79:69-102
30. Peng H, Lu Y (2012) Model selection in linear mixed effect models. J Multivariate Anal 109:109-129
31. Baker KD, Skuse DH (2005) Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group. Br J Psychiatry 186:115-120
32. Vorstman JAS, Morcus MEJ, Duijff SN, Klaassen PWJ, Heineman-de Boer JA, Beemer FA, Swaab H, Kahn RS, van Engeland H (2006) The 22q11.2 deletion in children: high rate of autistic disorders and early onset of psychotic symptoms. J Am Acad Child Adolesc Psychiatry 45 (9):1104-1113
33. Kumra S (2008) Digging deeper using neuroimaging tools reveals important clues to early-onset schizophrenia. J Am Acad Child Adolesc Psychiatry 47(10):1103-1104
34. Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T (2005) Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 62(9):975-983
35. Garety PA, Kuipers E, Fowler D, Freeman D, Bebbington PE (2001) A cognitive model of the positive symptoms of psychosis. Psychol Med 31(2):189-195
36. Dominguez MG, Saka MC, can Saka M, Lieb R, Wittchen HU, van Os J (2010) Early expression of negative/disorganized symptoms predicting psychotic experiences and subsequent clinical psychosis: a 10-year study. Am J Psych 167 (9):1075-1082
37. Riecher-Rössler A, Pflueger MO, Aston J, Borgwardt SJ, Brewer WJ, Gschwandtner U, Stieglitz R-D (2009) Efficacy of using cognitive status in predicting psychosis: a 7-year follow-up. Biol Psychiatry 66(11):1023-1030
38. Velthorst E, Nieman DH, Becker HE, van de Fliert R, Dingemans PM, Klaassen R, de Haan L, van Amelsvoort T, Linszen DH (2009) Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis. Schizophr Res 109(1-3):60-65
39. Duijff SN, Klaassen PWJ, de Veye HFNS, Beemer FA, Sinnema G, Vorstman JAS (2012) Cognitive development in children with 22q11.2 deletion syndrome. Br J Psychiatry 200:462-468
40. Beaton EA, Simon TJ (2011) How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? J Neurodev Disord 3(1):68-75
41. Bassett AS, McDonald-McGinn DM, Devriendt K, Digilio MC, Goldenberg P, Habel A, Marino B, Oskarsdottir S, Philip N, Sullivan K, Swillen A, Vorstman J (2011) Practical guidelines for managing patients with 22q11.2 deletion syndrome. J Pediatr 159(2):332-339