Panax notoginseng saponins (PNS) inhibits breast cancer metastasis

Journal of Ethnopharmacology

Volumn 154, Issue 3, 2014, Pages 663-671

  Wang, Peiwei ^a   Cui, Jingang ^a   Du, Xiaoye ^a   Yang, Qinbo ^a   Jia, Chenglin ^a   Xiong, Minqi ^a   Yu, Xintong ^a   Li, Li ^a   Wang, Wenjian ^a   Chen, Yu ^a   Zhang, Teng ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

4T1 mammary carcinoma; Metastasis; Panax notoginseng saponins

Indexed keywords

SAPONIN; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; FEMALE; GENE EXPRESSION; IN VITRO STUDY; LUNG METASTASIS; METASTASIS; MOUSE; NONHUMAN; PANAX NOTOGINSENG; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ISOLATION AND PURIFICATION; MAMMARY NEOPLASMS, ANIMAL; NEOPLASM METASTASIS; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ARALIACEAE; PANAX NOTOGINSENG;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; PANAX NOTOGINSENG; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84902546648     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.04.037     Document Type: Article

References (32)

1. S.K. Alahari, P.J. Reddig, and R.L. Juliano The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK EMBO J. 23 2004 2777 2788
2. P.F. Chen, L.M. Liu, Z. Chen, S.Y. Lin, W.X. Song, and Y.F. Xu Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice Zhong Xi Yi Jie He Xue Bao 4 2006 500 503
3. Z.G. Chen, P.W. Wang, B. Wei, X.M. Mo, and F.Z. Cui Electrospun collagen-chitosan nanofiber: a biomimetic extracellular matrix for endothelial cell and smooth muscle cell Acta Biomater. 6 2010 372 382
4. E.I. Deryugina, and J.P. Quigley Matrix metalloproteinases and tumor metastasis Cancer Metastasis Rev. 25 2006 9 34
5. J.S. Fan, D.N. Liu, G. Huang, Z.Z. Xu, Y. Jia, H.G. Zhang, X.H. Li, and F.T. He Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression J. Ethnopharmacol. 142 2012 732 738
6. S.Y. Han, H.X. Li, X. Ma, K. Zhang, Z.Z. Ma, Y. Jiang, and P.F. Tu Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats J. Ethnopharmacol. 145 2013 722 727
7. N.W. He, Y. Zhao, L. Guo, J. Shang, and X.B. Yang Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen J. Med. Food 15 2012 350 359
8. E. Kim, M.-R. Choi, H. Park, M. Kim, J. Hong, J.-Y. Lee, H. Chun, K. Lee, and J. Yoon Park Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice Breast Cancer Res. 13 2011 R78
9. T. Konoshima, M. Takasaki, and H. Tokuda Anti-carcinogenic activity of the roots of Panax notoginseng. II Biol. Pharm. Bull. 22 1999 1150 1152
10. J.-H. Lee, and D.R. Welch Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display Int. J. Cancer 71 1997 1035 1044
11. X. Li, G. Wang, J. Sun, H. Hao, Y. Xiong, B. Yan, Y. Zheng, and L. Sheng Pharmacokinetic and absolute bioavailability study of total panax notoginsenoside, a typical multiple constituent traditional chinese medicine (TCM) in rats Biol. Pharm. Bull. 30 2007 847 851
12. C.C. Liang, A.Y. Park, and J.L. Guan in vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro Nat. Protoc. 2 2007 329 333
13. G. Liu, B. Wang, J. Zhang, H. Jiang, and F. Liu Total panax notoginsenosides prevent atherosclerosis in apolipoprotein E-knockout mice: role of downregulation of CD40 and MMP-9 expression J. Ethnopharmacol. 126 2009 350 354
14. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408
15. A. Muller, B. Homey, H. Soto, N. Ge, D. Catron, M.E. Buchanan, T. McClanahan, E. Murphy, W. Yuan, S.N. Wagner, J.L. Barrera, A. Mohar, E. Verastegui, and A. Zlotnik Involvement of chemokine receptors in breast cancer metastasis Nature 410 2001 50 56
16. T.B. Ng Pharmacological activity of sanchi ginseng (Panax notoginseng) J. Pharm. Pharmacol. 58 2006 1007 1019
17. S.C. Park, H.S. Yoo, C. Park, C.K. Cho, G.Y. Kim, W.J. Kim, Y.W. Lee, and Y.H. Choi Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt Int. J. Oncol. 35 2009 121 127
18. E. Penna, F. Orso, D. Cimino, E. Tenaglia, A. Lembo, E. Quaglino, L. Poliseno, A. Haimovic, S. Osella-Abate, C. De Pitta, E. Pinatel, M.B. Stadler, P. Provero, M.G. Bernengo, I. Osman, and D. Taverna microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C EMBO J. 30 2011 1990 2007
19. B.A. Pulaski, and S. Ostrand-Rosenberg Mouse 4T1 breast tumor model Curr. Protoc. Immunol. 2001 10.1002/0471142735.im0471142002s0471142739 (Chapter, Unit 20.22.)
20. M.C. Smith, K.E. Luker, J.R. Garbow, J.L. Prior, E. Jackson, D. Piwnica-Worms, and G.D. Luker CXCR4 regulates growth of both primary and metastatic breast cancer Cancer Res. 64 2004 8604 8612
21. L.J. Stafford, K.S. Vaidya, and D.R. Welch Metastasis suppressors genes in cancer Int. J. Biochem. Cell Biol. 40 2008 874 891
22. K. Tao, M. Fang, J. Alroy, and G.G. Sahagian Imagable 4T1 model for the study of late stage breast cancer BMC Cancer 8 2008 228
23. D.F. Toh, D.N. Patel, E.C. Chan, A. Teo, S.Y. Neo, and H.L. Koh Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells Chin Med. 6 2011 1749 8546
24. C.Z. Wang, J.T. Xie, A. Fishbein, H.H. Aung, H. He, S.R. Mehendale, T.C. He, W. Du, and C.S. Yuan Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells Phytother. Res. 23 2009 6 13
25. Wang Nan, J.-B. Wan, Ming-yuen Lee, and Wang Yi-tao Advances in studies on Panax notoginseng against atherosclerosis Chin. Tradit Herb. Drugs 5 2008 787 791
26. W. Wang, H. Wang, E.R. Rayburn, Y. Zhao, D.L. Hill, and R. Zhang 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action Br. J. Cancer 98 2008 792 802
27. W. Wang, X. Zhang, J.J. Qin, S. Voruganti, S.A. Nag, M.H. Wang, H. Wang, and R. Zhang Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2 PLoS One 7 2012 e41586 (doi: 41510.41371/journal.pone.0041586. Epub 0042012 Jul 0041523)
28. X. Xiang, X. Zhuang, S. Ju, S. Zhang, H. Jiang, J. Mu, L. Zhang, D. Miller, W. Grizzle, and H.G. Zhang miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT Oncogene 30 2011 3440 3453
29. C.Y. Yang, J. Wang, Y. Zhao, L. Shen, X. Jiang, Z.G. Xie, N. Liang, L. Zhang, and Z.H. Chen Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components J. Ethnopharmacol. 130 2010 231 236
30. X.H. Yao, and X. Li Panax notoginseng saporins injection in treatment of cerebral infarction with a multicenter study Chin J New Drugs Clin. Rem. 20 2001 257 260
31. J. Zhang, and X.Y. Fang The historical condition in the spread of Sanqi (Panax notoginseng) in the Ming Dynasty Zhonghua Yi Shi Za Zhi 34 2004 16 20
32. L. Zhang, M.-X. Zhang, Y. Zhao, P. Zhang, J. Liu, J. Li, and Z.-H. Chen Saponins Isolated from the Root of Panax notoginseng Showed Significant Anti-Diabetic Effects in KK-Ay Mice Am. J. Chin. Med. 36 2008 939 951 Municipality Municipality