Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Roggia, Murilo Felix ^a   Imai, Hirotaka ^b   Shiraya, Tomoyasu ^a   Noda, Yasuo ^a   Ueta, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; MESSENGER RNA; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; VASCULOTROPIN A; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIPID PEROXIDATION; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBRETINAL NEOVASCULARIZATION; UPREGULATION; VEGF A GENE; ADVERSE EFFECTS; ANIMAL; CHOROIDAL NEOVASCULARIZATION; DISEASE MODEL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETICS; GENOTYPE; LASER; METABOLISM; PATHOLOGY; PHENOTYPE; TRANSGENIC MOUSE;

ANIMALS; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENETIC ASSOCIATION STUDIES; GENOTYPE; GLUTATHIONE PEROXIDASE; LASERS; MICE; MICE, TRANSGENIC; PHENOTYPE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84902531896     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098864     Document Type: Article

References (27)

1. Kahn HA, Leibowitz HM, Ganley JP, Kini MM, Colton T, et al. (1977) The Framingham Eye Study. I. Outline and major prevalence findings. Am J Epidemiol 106: 17-32. (Pubitemid 8160455)
2. Klaver CC, Wolfs RC, Vingerling JR, Hofman A, de Jong PT, et al. (1998) Agespecific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol 116: 653-658. (Pubitemid 28414581)
3. de Jong PT (2006) Age-related macular degeneration. N Engl J Med 355: 1474-1485.
4. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, et al. (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355: 1419-1431. (Pubitemid 44511557)
5. Lambert V, Lecomte J, Hansen S, Blacher S, Gonzalez ML, et al. (2013) Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice. Nat Protoc 11: 2197-2211.
6. Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, et al. (2006) Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A 103: 11282-11287. (Pubitemid 44156510)
7. Ebrahem Q, Renganathan K, Sears J, Vasanji A, Gu X, et al. (2006) Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A 103: 13480-13484. (Pubitemid 44380133)
8. Dong A, Xie B, Shen J, Yoshida T, Yokoi K, et al. (2009) Oxidative stress promotes ocular neovascularization. J Cell Physiol 219: 544-552.
9. Hara R, Inomata Y, Kawaji T, Sagara N, Inatani M, et al. (2010) Suppression of choroidal neovascularization by N-acetyl-cysteine in mice. Curr Eye Res 35: 1012-1020.
10. Chew EY, Clemons TE, Agrón E, Sperduto RD, Sangiovanni JP, et al. (2013) Age-Related Eye Disease Study Research Group. Long-term effects of vitamins C and E, b-carotene, and zinc on age-related macular degeneration: AREDS report no. 35. Ophthalmology 120: 1604-1611.e4.
11. Thomas JP, Geiger PG, Maiorino M, Ursini F, Girotti AW (1990) Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins. Biochim Biophys Acta 1045: 252-260. (Pubitemid 20249369)
12. Imai H, Hirao F, Sakamoto T, Sekine K, Mizukura Y, et al. (2003) Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem Biophys Res Commun 305: 278-286. (Pubitemid 36555464)
13. Ueta T, Tatsuya I, Takahisa F, Yasuhiro T, Yasuhito N, et al. (2012) Glutathione peroxidase 4 is required for maturation of photoreceptor cells. J Biol Chem 287: 7675-7682.
14. Wirth EK, Conrad M, Winterer J, Wozny C, Carlson BA, et al. (2010) Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J 24: 844-852.
15. Wortmann M, Schneider M, Pircher J, Hellfritsch J, Aichler M, et al. (2013) Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice. Circ Res 113: 408-417.
16. Imai H, Hakkaku N, Iwamoto R, Suzuki J, Suzuki T, et al. (2009) Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice. J Biol Chem 284: 32522-32532.
17. Ueta T, Inoue T, Yuda K, Furukawa T, Yanagi Y, et al. (2012) Intense physiological light upregulates vascular endothelial growth factor and enhances choroidal neovascularization via peroxisome proliferator-activated receptor c coactivator-1α in mice. Arterioscler Thromb Vasc Biol 32: 1366-1371.
18. Giani A, Thanos A, Roh MI, Connolly E, Trichonas G, et al. (2011) In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 52: 3880-3887.
19. Mizutani T, Ashikari M, Tokoro M, Nozaki M, Ogura Y (2009) Suppression of laser-induced choroidal neovascularization by a CCR3 antagonist. Invest Ophthalmol Vis Sci 54: 1564-1572.
20. Hu W, Criswell MH, Fong SL, Temm CJ, Rajashekhar G, et al. (2009) Differences in the temporal expression of regulatory growth factors during choroidal neovascular development. Exp Eye Res 88: 79-91.
21. Xie P, Kamei M, Suzuki M, Matsumura N, Nishida K, et al. (2011) Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344. PLoS One 6: e28933.
22. Imai H, Suzuki K, Ishizaka K, Ichinose S, Oshima H, et al. (2001) Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males. Biol Reprod 64: 674-683. (Pubitemid 32109758)
23. Liu J, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, et al. (2011). Relationship between complement membrane attack complex, chemokine (CC motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. J Biol Chem 286:20991-21001.
24. Kurihara T, Westenskow PD, Bravo S, Aguilar E, Friedlander M (2012) Targeted deletion of Vegfa in adult mice induces vision loss. J Clin Invest 122:4213-4217.
25. Oshima Y, Oshima S, Nambu H, Kachi S, Hackett SF, et al. (2004) Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization. J Cell Physiol 201: 393-400. (Pubitemid 39453125)
26. Lu L, Oveson BC, Jo YJ, Lauer TW, Usui S, et al. (2009) Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage. Antioxid Redox Signal 11:715-724.
27. Inomata Y, Tanihara H, Tanito M, Okuyama H, Hoshino Y, et al. (2008) Suppression of choroidal neovascularization by thioredoxin-1 via interaction with complement factor H. Invest Ophthalmol Vis Sci 49:5118-5125.