Early addition of topical corticosteroids in the treatment of bacterial keratitis

JAMA Ophthalmology

Volumn 132, Issue 6, 2014, Pages 737-741

  Ray, Kathryn J ^a,b   Srinivasan, Muthiah ^c   Mascarenhas, Jeena ^c   Rajaraman, Revathi ^c   Ravindran, Meenakshi ^c   Glidden, David V ^b   Oldenburg, Catherine E ^a   Sun, Catherine Q ^a   Zegans, Michael E ^d   McLeod, Stephen D ^a,b   Acharya, Nisha R ^a,b   Lietman, Thomas M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ARAVIND EYE CARE SYSTEM   (India)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; MOXIFLOXACIN; PLACEBO;

ADD ON THERAPY; ADJUVANT THERAPY; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL KERATITIS; CONTROLLED CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CORNEA ULCER; CORTICOSTEROID THERAPY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOCARDIOSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TREATMENT DURATION; VISUAL ACUITY; VISUAL IMPAIRMENT;

ADMINISTRATION, TOPICAL; ADULT; AZA COMPOUNDS; CONFIDENCE INTERVALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; EYE INFECTIONS, BACTERIAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; KERATITIS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDNISOLONE; QUINOLINES; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84902491371     PISSN: 21686165     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaophthalmol.2014.292     Document Type: Article

References (17)

1. Acharya NR, Srinivasan M, Mascarenhas J, et al. The steroid controversy in bacterial keratitis. Arch Ophthalmol. 2009;127(9):1231.
2. Blair J, Hodge W, Al-Ghamdi S, et al. Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. Can J Ophthalmol. 2011;46(1):40-45.
3. Wilhelmus KR. Indecision about corticosteroids for bacterial keratitis: an evidence-based update. Ophthalmology. 2002;109(5):835-843.
4. Hindman HB, Patel SB, Jun AS. Rationale for adjunctive topical corticosteroids in bacterial keratitis. Arch Ophthalmol. 2009;127(1):97-102.
5. Cohen EJ. The case against the use of steroids in the treatment of bacterial keratitis. Arch Ophthalmol. 2009;127(1):103-104.
6. Srinivasan M, Mascarenhas J, Rajaraman R, et al. Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). Arch Ophthalmol. 2012;130(2):143-150.
7. Srinivasan M, Mascarenhas J, Rajaraman R, et al. The Steroids for Corneal Ulcers Trial: study design and baseline characteristics. Arch Ophthalmol. 2012;130(2):151-157.
8. Srinivasan M, Mascarenhas J, Rajaraman R, et al. The Steroids for Corneal Ulcers Trial (SCUT): 12-month clincial outcomes of a randomized controlled trial. Am J Ophthalmol. 2014;157(2):327-333.e3.
9. Lalitha P, Srinivasan M, Rajaraman R, et al. Nocardia keratitis: clinical course and effect of corticosteroids. Am J Ophthalmol. 2012;154(6):934-939.e1.
10. Jones DB. Corticosteroids for bacterial keratitis: who gets them? JAMA Ophthalmol. 2013;131(2):233-235.
11. Rao SK, Madhavan HN, Sitalakshmi G, Padmanabhan P. Nocardia asteroides keratitis: report of seven patients and literature review. Indian J Ophthalmol. 2000;48(3):217-221. (Pubitemid 32221964)
12. Matuska S, Rama P, Cavallero A, Paganoni G, Spinelli A, Brancato R. Nocardia keratitis: a case report. Eur J Ophthalmol. 2006;16(1):164-167.
13. Oxman AD, Guyatt GH. A consumer's guide to subgroup analyses. Ann Intern Med. 1992;116(1):78-84.
14. Amescua G, Miller D, Alfonso EC. What is causing the corneal ulcer? management strategies for unresponsive corneal ulceration. Eye (Lond). 2012;26(2):228-236.
15. Wong T, Ormonde S, Gamble G, McGhee CNJ. Severe infective keratitis leading to hospital admission in New Zealand. Br J Ophthalmol. 2003;87(9):1103-1108. (Pubitemid 37064885)
16. Stern GA, Buttross M. Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease. Ophthalmology. 1991;98(6):847-853.
17. Hancock MJ, Kjaer P, Korsholm L, Kent P. Interpretation of subgroup effects in published trials. Phys Ther. 2013;93(6):852-859.