What is causing the corneal ulcer Management strategies for unresponsive corneal ulceration

Eye

Volumn 26, Issue 2, 2012, Pages 228-236

  Amescua, G ^a   Miller, D ^a   Alfonso, E C ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

approach to corneal ulcers; corneal ulcer; infectious keratatis treatment

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; ATROPINE; CEPHALOSPORIN; CHLORHEXIDINE; CORTICOSTEROID; CYCLOSPORIN; MOXIFLOXACIN; NATAMYCIN; POLY(HEXAMETHYLENEBIGUANIDE); PREDNISOLONE ACETATE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TOBRAMYCIN; VANCOMYCIN; VORICONAZOLE;

ALGORITHM; COMBINATION CHEMOTHERAPY; CONFERENCE PAPER; DRUG PENETRATION; HUMAN; KERATITIS; KERATOPLASTY; MONOTHERAPY; PRESUMED INFECTIOUS KERATITIS;

EID: 84863061007     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2011.316     Document Type: Conference Paper

References (30)

1. Pepose JS, Wilhelmus KR. Divergent approaches to the management of corneal ulcers. Am J Ophthalmol 1992; 114(5): 630-632.
2. Jeng BH, Gritz DC, Kumar AB. Epidemiology of ulcerative keratitis in Northern California. Arch Ophthalmol 2010; 128(8): 1022-1028.
3. Basak SK, Basak S, Mohanta A, Bhowmick A. Epidemiological and microbiological diagnosis of suppurative keratitis in Gangetic West Bengal, eastern India Indian. J Ophthalmol 2005; 53(1): 17-22. (Pubitemid 40524386)
4. Wilhelmus KR. Indecision about corticosteroids for bacterial keratitis: an evidence-based update. Ophthalmology 2002; 109(5): 835-842. (Pubitemid 34465213)
5. Cheng KH, Leung SL, Hoekman HW, Beekhuis WH, Mulder PG, Geerards AJ et al. Incidence of contact lens-associated microbial keratitis and its related morbidity. Lancet 1999; 354: 181-185. (Pubitemid 29329155)
6. O'Brien TP. Evidence based review of moxifloxacin. Int Ophthalmol Clin 2006 Fall 46(4): 61-72.
7. Chawla B, Agarwal P, Tandon R, Titiyal JS, Sharma N, Agarwal T et al. In vitro susceptibility of bacterial keratitis isolates to fourth-generation fluoroquinolones. Eur J Ophthalmol 2010; 20(2): 300-305.
8. McDonnel PJ, Nobe J, Gauderman WJ, Lee P, Aiello A, Trousdale M. Community care of corneal ulcers. Am J Ophthalmol 1992; 114: 531-538.
9. Krachmer JH, Mannis MJ, Holland EJ. Cornea: Fundamentals, Diagnosis and Treatment, vol. 1, 3rd edn. Mosby-Elsevier: Philadelphia, PA, USA; pp 936-938.
10. Sharma N, Sachdev R, Jhanji V, Titiyal JS, Vajpayee RB. Therapeutic keratoplasty for microbial keratatis. Curr Opin Ophthalmol 2010; 21: 293-300.
11. Alexandrakis G, Haimovici R, Miller D, Alfonso EA. Corneal biopsy in the management of pregressive microbial keratitis. Am J Ophthalmol 2000; 129: 571-576. (Pubitemid 30323720)
12. Buchser NM, Dubovy SR, Miller D. Detection of organisms by microbiology vs. histopathology in corneal biopsy and penetrating keratoplasty specimens. Invest Ophthalmol Vis Sci 2009; 50: E-abstract 5119.
13. Jones DB. Early diagnosis and therapy of bacterial corneal ulcers. Int Ophthalmol Clin 1973 Winter 13(4): 1-29.
14. Kaufman SC, Musch DC, Belin MW, Cohen EJ, Meisler DM, Reinhart WJ et al. Confocal microscopy: a report by the American Academy of Ophthalmology. Ophthalmology 2004; 111(2): 396-406. (Pubitemid 38183252)
15. Ford JG, Huang AJ, Pflugfelder SC, Alfonso EC, Forster RK, Miller D. Mycobacterial keratitis in South Florida. Ophthalmology 1998; 105(9): 1652-1658.
16. Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Lalitha P, Glidden DV et al. Corticosteroids for Bacterial Keratitis: the Steroids for Corneal Ulcers Trial (SCUT). Arch Ophthalmol 2011; e-pub ahead of print 10 October 2011; doi:10.1001/archophthalmol.2011.315.
17. Thompson PP, Kowalski RP. A 13-year retrospective review of polymerase chain reaction testing for infectious agents from ocular samples. Ophthalmology 2011; 118(7): 1449-1453.
18. Martins SAR, Combs JC, Noguera G, Camacho W, Wittmann P, Walther R et al. Antimicrobial efficacy of riboflavin/UVA combination (365 n). In vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis. Invest Ophthalmol Vis Sci 2008; 49: 3402-3408.
19. Iseli HP, Thiel AM, Hafezi F, Kampmeier J, Seiler T. Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea 2008; 27(5): 590-594.
20. Micelli Ferrari T, Leozappa M, Lorusso M. Escherichia coli keratitis treated with ultraviolet A/riboflavin corneal cross-linking: a case report. Eur J Ophthalmol 2009; 19(2): 295-297.
21. Marangon FB, Miller D, Alfonso EC. Impact of prior therapy on the recovery and frequency of corneal pathogens. Cornea 2004; 23(2): 158-164. (Pubitemid 38292710)
22. Ventura R, Miller D, Alfonso E. Laboratory update on microbial keratitis in South Florida. ARVO Meeting Abstr 2009; 50: 3115.
23. Yoo SH, Kymionis GD, O'Brien TP, Ide T, Culbertson W, Alfonso EC. Femtosecond-assisted diagnostic corneal biopsy (FAB) in keratitis. Graefes Arch Clin Exp Ophthalmol 2008; 246: 759-762.
24. Deng SX, Kamal KM, Hollander DA. The use of voriconazol in the management of post-penetrating keratoplasty Paecilomyces keratitis. J Ocul Pharmacol Ther 2009; 25(2): 175-177.
25. Utine CA, Stern M, Akpek EK. Clinical Review: topical ophthalmic use of cyclosporine A. Ocul Immunol Inflamm 2010; 18(5): 352-361.
26. Rodman RC, Spisak S, Sugar A. The utility of culturing corneal ulcer in the tertiary referral center verus a general ophthalmology clinic. Ophthalmology 1997; 104(11): 1897-1901. (Pubitemid 28100348)
27. Saini JS, Jain AK, Kumar S, Vikal S, Pankaj S, Singh S. Neural network approach to classify infective keratitis. Curr Eye Res 2003; 27(2): 111-116. (Pubitemid 37041196)
28. Chandna A, Fisher AC, Cunningham I, Stone D, Mitchell M. Pattern recognition of vertical strabismus using an artificial neural network (StrabNet). Strabismus 2009; 17(4): 131-138.
29. Bizios D, Heijl A, Bengtsson B. Trained artificial neural network for glaucoma diagnosis using visual field data: a comparison with conventional algorithms. J Glaucoma 2007; 16(1): 20-28. (Pubitemid 46114769)
30. Kaiserman I, Rosner M, Peer J. Forcasting the prognosis of choroidal melanoma with an artificial neural network. Ophthalmology 2005; 112(9): 1608.