Visualization and communication of pharmacometric models with Berkeley Madonna

CPT: Pharmacometrics and Systems Pharmacology

Volumn 3, Issue 5, 2014, Pages

  Krause, A ^a   Lowe, P J ^b  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

ARTICLE; BLOOD PRESSURE; CIRCADIAN RHYTHM; COMPARTMENT MODEL; COMPUTER PROGRAM; DRUG ABSORPTION; DRUG ADMINISTRATION; DRUG DEVELOPMENT; DRUG DISPOSITION; LICENSING; PHARMACODYNAMICS; PHARMACOKINETICS; PHARMACOLOGICAL PARAMETERS; PHARMACOMETRIC; PLACEBO EFFECT; PRIORITY JOURNAL; SIMULATION;

EID: 84902475481     PISSN: None     EISSN: 21638306     Source Type: Journal    
DOI: 10.1038/psp.2014.13     Document Type: Article

References (35)

1. Roosen, C., Pugh, R. & Nicholls, A. Exploring pharmacokinetic and pharmacodynamic data. A Picture Is Worth a Thousand Tables - Graphics in Life Sciences, 99-115 (Springer, New York, 2012).
2. Mould, D.R. & Upton, R.N. Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods. CPT. Pharmacometrics Syst. Pharmacol. 2, e38 (2013).
3. Upton, R.N. & Mould, D.R. Basic concepts in population modeling, simulation, and model-based drug development: part 3-introduction to pharmacodynamic modeling methods. CPT. Pharmacometrics Syst. Pharmacol. 3, e88 (2014).
4. Tukey, J.W. Exploratory Data Analysis (Pearson, 1977).
5. Dykstra, K., Pugh, R. & Krause, A. Visualization concepts to enhance quantitative decision making in drug development. J. Clin. Pharmacol. 50, 130S-139S (2010).
6. Yano, Y., Beal, S.L. & Sheiner, L.B. Evaluating pharmacokinetic/ pharmacodynamic models using the posterior predictive check. J. Pharmacokinet. Pharmacodyn. 28, 171-192 (2001).
7. Holford, N.H. The visual predictive check - superiority to standard diagnostic (Rorschach) plots (2005).
8. Holford, N.H. An introduction to visual predictive checks (2012).
9. Karlsson, M.O. A tutorial on visual predictive checks (2008).
10. Beal, S.L. & Sheiner, L.B. NONMEM Users Guides (Icon Development Solutions, Ellicott City, MD, 1989-98).
11. Lixoft-Incuballiance. Monolix User Guide 4.2.0 edn. Lixoft-Incuballiance, Paris, (2012).
12. Tufte, E.R. Envisioning Information (Graphics Press, Cheshire, CT, 1990).
13. Tufte, E.R. The Visual Display of Quantitative Information (Graphics Press, Cheshire, CT, 2001).
14. Tufte, E.R. Beautiful Evidence (Graphics Press, Cheshire, CT, 2007).
15. Cleveland, W.R. Visualizing Data (Hobart Press, Summit, NJ 1993).
16. Krause, A. Concepts and principles of clinical data graphics. In A Picture Is Worth a Thousand Tables - Graphics in Life Sciences (eds. Krause, A. & O'Connell, M.) 3-21 (Springer, New York, 2012).
17. Gobburu, J.V. Pharmacometrics 2020. J Clin Pharmacol. 2010, 50 (suppl. 9), 151S-157S.
18. Krause, A. & Gieschke, R. Interactive visualization and communication for increased impact of pharmacometrics. J. Clin. Pharmacol. 50, 140S-145S (2010).
19. Bonate, P.L. Pharmacokinetic-pharmacodynamic modeling and simulation (Springer, New York, 2011).
20. Lachmann, H.J. et al. In vivo regulation of interleukin 1beta in patients with cryopyrinassociated periodic syndromes. J Experiment Med. 206, 1029-1036 (2009).
21. Berkeley Madonna. Modeling and analysis of dynamic systems Accessed 29 April, 2014.
22. Mould, D.R. & Upton, R.N. Basic concepts in population modeling, simulation, and model-based drug development. CPT. Pharmacometrics Syst. Pharmacol. 1, e6 (2012).
23. Lowe, P.J. Building kinetic models in Berkeley Madonna: the one compartment model (2006).
24. Lowe, P.J. Building kinetic models in Berkeley Madonna: the two compartment model (2006).
25. Lowe, P.J. Building kinetic models in Berkeley Madonna: the one compartment first-order absorption model with variability in parameters (2006).
26. R Development Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna, Austria, 2009).
27. Lowe, P.J., Tannenbaum, S., Wu, K., Lloyd, P. & Sims, J. On setting the first dose in man: quantitating biotherapeutic drug-target binding through pharmacokinetic and pharmacodynamic models. Basic Clin. Pharmacol. Toxicol. 106, 195-209 (2010).
28. Meno-Tetang, G.M. & Lowe, P.J. On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach. Basic Clin. Pharmacol. Toxicol. 96, 182-192 (2005). (Pubitemid 40387994)
29. Lowe, P.J. Building kinetic models in Berkeley Madonna: binding model test tube. (2006).
30. Golub, G.H. & Van Loan, C.F. Matrix Computations (Johns Hopkins University Press, Baltimore and London, 1996).
31. Butcher, J.C. Numerical Methods for Ordinary Differential Equations 2 edn. (Wiley, Chichester, UK, 2008).
32. Euler, L. Institutionum Calculi Integralis (Acad. Scient. Borussiae Directore Vicennali Et Socio, Acad. Petrop. Parisin. Et Londin, St Petersburg, 1768-1770).
33. Rosenbrock, H.H. Some general implicit processes for the numerical solution of differential equations. Comput J. 5, 329-330 (1963).
34. Berkeley Madonna. Berkeley Madonna User Group on LinkedIn
35. Lixoft-Incuballiance. MLXPlore: Monolix Model Explorer Version 1.0.0 4.2.0 edn. Lixoft-Incuballiance, Paris, (2014).