Adrenomedullin: A vasodilator to treat sepsis?

Critical Care

Volumn 18, Issue 3, 2014, Pages

  Pugin, Jérôme ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; CARDIOTONIC AGENT; PROADRENOMEDULLIN; PROCALCITONIN; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; BRONCHODILATING AGENT;

ARTIFICIAL VENTILATION; BACTERIAL LOAD; BLOOD VESSEL TONE; BRONCHODILATATION; CELL DEATH; ENDOTHELIUM CELL; HOMEOSTASIS; INFLAMMATION; INTENSIVE CARE; KIDNEY DISEASE; MICROCIRCULATION; NONHUMAN; NOTE; PLEIOTROPY; PRIORITY JOURNAL; SEPSIS; SEQUENCE HOMOLOGY; STREPTOCOCCUS PNEUMONIA; VENTILATOR INDUCED LUNG INJURY; ADVERSE EFFECTS; ANIMAL; FEMALE; PNEUMONIA, PNEUMOCOCCAL; VENTILATOR-INDUCED LUNG INJURY;

ADRENOMEDULLIN; ANIMALS; BRONCHODILATOR AGENTS; FEMALE; PNEUMONIA, PNEUMOCOCCAL; RESPIRATION, ARTIFICIAL; SEPSIS; VENTILATOR-INDUCED LUNG INJURY;

EID: 84902472297     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13924     Document Type: Note

References (8)

1. Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M. Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin. Crit Care 2014, 18:R73. 10.1186/cc13830, 24731244.
2. Lopez J, Martinez A. Cell and molecular biology of the multifunctional peptide, adrenomedullin. Int Rev Cytol 2002, 221:1-92.
3. Zudaire E, Portal-Nunez S, Cuttitta F. The central role of adrenomedullin in host defense. J Leukoc Biol 2006, 80:237-244. 10.1189/jlb.0206123, 16769769.
4. Suberviola B, Castellanos-Ortega A, Llorca J, Ortiz F, Iglesias D, Prieto B. Prognostic value of proadrenomedullin in severe sepsis and septic shock patients with community-acquired pneumonia. Swiss Med Wkly 2012, 142:w13542.
5. Muller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S. Adrenomedullin attenuates ventilator-induced lung injury in mice. Thorax 2010, 65:1077-1084. 10.1136/thx.2010.135996, 20971983.
6. Bregeon F, Delpierre S, Chetaille B, Kajikawa O, Martin TR, Autillo-Touati A, Jammes Y, Pugin J. Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Anesthesiology 2005, 102:331-339. 10.1097/00000542-200502000-00015, 15681948.
7. Charles PE, Martin L, Etienne M, Croisier D, Piroth L, Lequeu C, Pugin J, Portier H, Chavanet P. Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation. Intensive Care Med 2004, 30:2263-2270. 10.1007/s00134-004-2442-y, 15536527.
8. Wagner K, Wachter U, Vogt JA, Scheuerle A, McCook O, Weber S, Gröger M, Stahl B, Georgieff M, Möller P, Bergmann A, Hein F, Calzia E, Radermacher P, Wagner F. Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock. Intens Care Med Exp 2013, 1:2.