White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke

Journal of Stroke and Cerebrovascular Diseases

Volumn 23, Issue 6, 2014, Pages 1300-1306

  Corbin, Zachary A ^a   Rost, Natalia S ^a   Lorenzano, Svetlana ^a   Kernan, Walter N ^b   Parides, Michael K ^c   Blumberg, Jeffrey B ^d   Milbury, Paul E ^d   Arai, Ken ^a   Hartdegen, Sophia N ^a   Lo, Eng H ^a   Feske, Steven K ^a   Furie, Karen L ^a,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d TUFTS UNIVERSITY   (United States)

^e BROWN UNIVERSITY   (United States)

Author keywords

F2 isoprostane(s); Leukoaraiosis; matrix metalloproteinase 2; oxidative stress; stroke; white matter hyperintensity

Indexed keywords

GELATINASE A; GELATINASE B; ISOPROSTANE DERIVATIVE; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CORRELATION COEFFICIENT; FEMALE; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; WHITE MATTER; WHITE MATTER HYPERINTENSITY VOLUME; BLOOD; BRAIN; CEREBROVASCULAR ACCIDENT; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BRAIN; BRAIN ISCHEMIA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; OXIDATIVE STRESS; STROKE; WHITE MATTER;

EID: 84902455966     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2013.11.002     Document Type: Article

References (24)

1. H. Ay, E.M. Arsava, and J. Rosand et al. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke Stroke 39 2008 1409 1413
2. E.M. Arsava, R. Rahman, and J. Rosand et al. Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke Neurology 72 2009 1403 1410
3. B. Kissela, C.J. Lindsell, and D. Kleindorfer et al. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race Stroke 40 2009 530 536
4. L. Pantoni, and J.H. Garcia Pathogenesis of leukoaraiosis: a review Stroke 28 1997 652 659
5. B. Ovbiagele, and J. Saver Cerebral white matter hyperintensities on MRI: current concepts and therapeutic implications Cerebrovasc Dis 22 2005 83 90
6. J. Helenius, and T. Tatlisumak Treatment of leukoaraiosis: a futuristic view Curr Drug Targets 8 2007 839 845
7. R. Topakian, T.R. Barrick, and F.A. Howe et al. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leukoaraiosis J Neurol Neurosurg Psychiatry 81 2010 192 197
8. J.M. Wardlaw, P.A.G. Sandercock, and M.S. Dennis et al. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 34 2003 806 812
9. J.M. Wardlaw, A. Farrall, and P.A. Armitage et al. Changes in background blood-brain barrier integrity between lacunar and cortical ischemic stroke subtype Stroke 39 2008 1327 1332
10. S. Liu, W. Liu, and W. Ding et al. Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia J Cereb Blood Flow Metab 26 2006 1274 1284
11. H. Shibata, T. Nabika, and H. Moriyama et al. Correlation of NO metabolites and 8-iso prostaglandin F2a with periventricular hyperintensity severity Arterioscler Thromb Vasc Biol 24 2004 1659 1663
12. R. Schmidt, M. Hayn, and F. Fazekas et al. Magnetic resonance imaging white matter hyperintensities in clinically normal elderly individuals: correlations with plasma concentrations of naturally occurring antioxidants Stroke 27 1996 2043 2047
13. J.D. Morrow Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans Arterioscler Thromb Vasc Biol 27 2005 279 286
14. E. Candelario-Jalil Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics Curr Opin Investig Drugs 10 2009 644 654
15. K.O. Cho, H.O. La, and Y.J. Cho et al. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion J Neurosci Res 83 2006 285 291
16. K. Nakaji, M. Ihara, and C. Takahashi et al. Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents Stroke 37 2006 2816 2823
17. E. Candelario-Jalil, J. Thompson, and S. Taheri et al. Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment Stroke 42 2011 1345 1350
18. Furie KL. Oxidative stress and MMPs (2006). Available at: http://projectreporter.nih.gov/project-info-description.cfm?aid= 7138842&icde=130559652006.
19. Gurol ME, Bottiglieri T, Diaz-Arrastia R, et al. Homocysteine, brain atrophy, and white matter disease in Alzheimer's disease and cerebral amyloid angiopathy. American Neurological Association Annual Meeting 2004, Toronto, Canada.
20. N.S. Rost, R.M. Rahman, and A. Biffi et al. White matter hyperintensity volume is increased in small vessel stroke subtypes Neurology 75 2010 1670 1677
21. M. Ihara, H. Tomimoto, and M. Kinoshita et al. Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter J Cereb Blood Flow Metab 21 2001 828 834
22. V. Lucivero, M. Prontera, and D.M. Mezzapesa et al. Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke Neurol Sci 28 2007 165 170
23. Y. Yang, and G.A. Rosenberg Blood-brain barrier breakdown in acute and chronic cerebrovascular disease Stroke 42 2011 3323 3328
24. Z. Szolnoki Chemical events behind leukoaraiosis: medicinal chemistry offers new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype) Curr Med Chem 14 2007 1027 1036