Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in invivo model

Clinical Nutrition

Volumn 33, Issue 4, 2014, Pages 718-726

  Sharmila, G ^a   Bhat, F A ^a   Arunkumar, R ^a   Elumalai, P ^a   Raja Singh, P ^a   Senthilkumar, K ^b   Arunakaran, J ^a  

^a UNIVERSITY OF MADRAS   (India)

^b Pukyong National University   (South Korea)

Author keywords

Antioxidant enzymes; Apoptosis; Cell survival; Proliferation; Prostate cancer; Quercetin

Indexed keywords

ANDROGEN RECEPTOR; CASPASE 3; CASPASE 8; CASPASE 9; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; QUERCETIN; RAF PROTEIN; SOMATOMEDIN C RECEPTOR; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; CASP8 PROTEIN, RAT; CASP9 PROTEIN, RAT; CDK1 PROTEIN, RAT; CYCLIN DEPENDENT KINASE; INSULIN-LIKE GROWTH FACTOR-1, RAT; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHENOL; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER MODEL; CANCER PREVENTION; CELL PROLIFERATION; CELL SURVIVAL; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN VIVO STUDY; MALE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CYCLE CHECKPOINT; DRUG EFFECTS; GENETICS; METABOLISM; PROSTATIC NEOPLASMS; SPRAGUE DAWLEY RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASES; INSULIN-LIKE GROWTH FACTOR I; MALE; PHOSPHATIDYLINOSITOL 3-KINASES; POLYPHENOLS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84902385984     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.08.011     Document Type: Article

References (34)

1. Siegel R., Naishadham D., Jemal A. Cancer statistics. CA Cancer J Clin 2012, 62:10-29.
2. Cox M.E., Gleave M.E., Zakikhani M., Bell R.H., Piura E., Vickers E., et al. Insulin receptor expression by human prostate cancers. Prostate 2009, 69:33-40.
3. Pollak M.N., Schernhammer E.S., Hankinson S.E. Insulin- like growth factors and neoplasia. Nat Rev Cancer 2004, 4:505-518.
4. Nicholson K.M., Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002, 14:381-395.
5. Kajanne R., Miettinen P., Tenhunen M., Leppa S. Transcription factor AP-1 promotes growth and radio resistance in prostate cancer cells. Int J Oncol 2009, 35:1175-1182.
6. Ozkan E.E. Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases, a review. Mol Cell Endocrinol 2011, 344:1-24.
7. Heinlein C.A., Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004, 25:276-308.
8. Vermeulen K., Van Bockstaele D.R., Berneman Z.N. Apoptosis: mechanisms and relevance in cancer. Ann Hematol 2005, 84:627-639.
9. Choi E.J., Bae S.M., Ahn W.S. Anti proliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch Pharm Res 2009, 31:1281-1295.
10. Jung Y.H., Heo J., Lee Y.J., Kwon T.K., Kim Y.H. Quercetin enhances TRAIL induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5. Life Sci 2010, 86:351-357.
11. Senthilkumar K., Elumalai P., Arunkumar R., Banudevi S., Gunadharini N.D., Sharmila G., et al. Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem 2010, 344:173-184.
12. Mccormick D.L., Rao K.V. Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever rat. Eur Urol 1999, 35:464-467.
13. Liao Z., Boileau T.W., Erdman J.W., Clinton S.K. Interrelationships among angiogenesis, proliferation, and apoptosis in the tumor microenvironment during N-methyl-N-nitrosourea androgen-induced prostate carcinogenesis in rats. Carcinogenesis 2002, 23:1701-1712.
14. Seufi A.M., Ibrahim S.S., Elmaghraby T.K., Hafez E.E. Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences. JExp Clin Cancer Res 2009, 28:80.
15. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974, 47:469-474.
16. Sinha A.K. Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
17. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
18. Staal G.E., Visser J., Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969, 185:39-48.
19. Habig W.H., Pabst M.J., Fleischner G., Gatmaitan Z., Arias I.M., Jakoby W.B. The identity of glutathione S-transferase B with ligand in, a major binding protein of liver. PNAS 1974, 71:3879-3882.
20. Banudevi S., Elumalai P., Sharmila G., Arunkumar R., Senthilkumar K., Arunakaran J. Protective effect of zinc on N-methyl-N-nitrosourea and testosterone-induced prostatic intraepithelial neoplasia in the dorsolateral prostate of Sprague Dawley rats. Exp Biol Med 2011, 1012:1-10.
21. Sharmila G., Athirai T., Kiruthiga B., Senthilkumar K., Elumalai P., Arunkumar R., et al. Chemoprevention of prostate carcinogenesis by a flavonoid quercetin in cancer-induced (MNU and Testosterone) male Sprague Dawley rats. Nutr Cancer 2013, (Accepted - Manuscript ID N&C-12-12-1573.R3).
22. Barrenetxe J., Aranguren P., Grijalba A., Martinez-Penuela J.M., Marzo F., Urdaneta E. Effect of dietary quercetin and sphingomyelin on intestinal nutrient absorption and animal growth. Br J Nutr 2006, 95:455-461.
23. Ruiz M.J., Fernández M., Estela J.M., Asensi M., Manes J., Picó Y. Short-term oral toxicity of quercetin and pterostibene in Swiss mice. Toxicol Lett 2006, 164:S275-S276.
24. Selvakumar K., Arunakaran J. Oxidative stress, biomarkers and antioxidants relevant to prostate cancer and neurodegeneration: potential role of quercetin. Int J Nat Prod Res 2013, 2:8-16.
25. Min Y.K., Lee J.E., Chung K.C. Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3beta signaling. Exp Cell Res 2007, 313:312-321.
26. Zhoul Q., Shi X.L., Jiang B.H., Fang J. Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Carcinogenesis 2007, 28:713-723.
27. Papageorgiou E., Pitulis N., Msaouel P., Lembessis P., Koutsilieris M. The non-genomic crosstalk between PPAR-gamma ligands and ERK1/2 in cancer cell lines. Expert Opin Ther Targets 2007, 11:1071-1085.
28. Senthilkumar K., Arunkumar R., Elumalai P., Sharmila G., Gunadharini D.N., Banudevi S., et al. Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct 2011, 29:87-95.
29. Kim D., Gregory C.W., French F.S., Smith G.J., Mohler J.L. Androgen receptor expression and cellular proliferation during transition from androgen dependent to recurrent growth after castration in the CWR22 prostate cancer xenografts. Am J Pathol 2002, 160:219-226.
30. Shiota M., Yokomizo A., Naito S. Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer. Free Radic Biol Med 2011, 51:1320-1328.
31. Ferguson J., Zincke H., Ellison E., Bergstralh E., Bostwick D.G. Decrease of prostatic intraepithelial neoplasia following androgen deprivation therapy in patients with stage T3 carcinoma treated by radical prostatectomy. Urology 1994, 44:91-95.
32. Xing N., Chen Y., Mitchell S.H., Charles Y.F.Y. Quercetin, a flavonoid found in apples, onions, red wine, and tea, has been reported to inhibit AR expression, resulting in inhibition of LNCaP cell growth. Carcinogenesis 2001, 22:409-414.
33. Chowdhury S.A., Kishino K., Satoh R., Hashimoto K., Kikuchi H., Nishikawa H., et al. Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anti Cancer Res 2005, 25:2055-2063.
34. Lee W.J., Chen Y.R., Tseng T.H. Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep 2011, 25:583-591.