Deficiency in perlecan/HSPG2 during bone development enhances osteogenesis and decreases quality of adult bone in mice

Calcified Tissue International

Volumn 95, Issue 1, 2014, Pages 29-38

  Lowe, Dylan A ^a   Lepori Bui, Nadia ^a   Fomin, Peter V ^a   Sloofman, Laura G ^a,c   Zhou, Xiaozhou ^a   Farach Carson, Mary C ^a,b   Wang, Liyun ^a   Kirn Safran, Catherine B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b RICE UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Bone quality; Dyssegmental dysplasia; Heparan sulfate; Perlecan; Proteoglycan; Schwartz Jampel syndrome; Silverman Handmaker

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN 2; CHAPERONE; COLLAGEN TYPE 10; HEPARAN SULFATE PROTEOGLYCAN 2; OSTEOCALCIN; PERLECAN; PHOSPHATASE; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY WEIGHT; BONE BOWING; BONE DENSITY; BONE DEVELOPMENT; BONE GEOMETRY; BONE MINERAL; BONE MINERALIZATION; BONE QUALITY; CARTILAGE; CARTILAGE CELL; CARTILAGE MATRIX; CELL MUTANT; COMPARATIVE STUDY; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; CORTICAL BONE; CORTICAL THICKNESS (BONE); EMBRYO; GEOMETRY; GROWTH PLATE; HETEROZYGOTE; IMAGING SOFTWARE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MUSCULOSKELETAL SYSTEM PARAMETERS; MUTANT; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RIGIDITY; SEX; YOUNG MODULUS; AGING; ANIMAL; BONE; C57BL MOUSE; CONFOCAL MICROSCOPY; DEFICIENCY; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MUTANT MOUSE STRAIN; PHYSIOLOGY;

AGING; ANIMALS; BONE AND BONES; BONE DEVELOPMENT; FEMALE; HEPARAN SULFATE PROTEOGLYCANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, CONFOCAL; OSTEOGENESIS; X-RAY MICROTOMOGRAPHY;

EID: 84902358461     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-014-9859-2     Document Type: Article

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