Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice

Journal of Orthopaedic Research

Volumn 27, Issue 1, 2009, Pages 28-35

  Oristian, Daniel S ^a   Slooíman, Laura G ^a   Zhou, Xiaozhou ^a   Wang, Liyun ^a   Farach Carson, Mary C ^a   Kirn Safran, Catherine B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Bone growth delay; Protein translation; Ribosomal protein; RPL29 knockout; Skeletal fragility

Indexed keywords

RIBOSOME PROTEIN; RIBOSOME PROTEIN L29; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE FRAGILITY; BONE MASS; CELL CYCLE; CONTROL GROUP; CONTROLLED STUDY; CORTICAL BONE; EMBRYO; FEMALE; FRACTURE; GENOTYPE; KNOCKOUT MOUSE; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RISK FACTOR;

ANIMALS; BIOMECHANICS; BONE AND BONES; CELL PROLIFERATION; FEMALE; FRACTURE HEALING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, GENETIC; OSTEOGENESIS; RIBOSOMAL PROTEINS; RIBOSOMES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 58149252065     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20706     Document Type: Article

References (27)

1. Moritz M, Pulaski BA, Woolford JL Jr. 1991. Assembly of 60S ribosomal subunits is perturbed in temperature-sensitive yeast mutants defective in ribosomal protein L16. Mol Cell Biol 11:5681-5692.
2. Dresios J, Panopoulos P, Frantziou CP, et al. 2001. Yeast ribosomal protein deletion mutants possess altered peptidyltransferase activity and different sensitivity to cyclo- heximide. Biochemistry 40:8101-8108.
3. Powers T. 2004. Ribosome biogenesis: giant steps for a giant problem. Cell 119:901-902.
4. Pende M. 2006. mTOR, Akt, S6 kinases and the control of skeletal muscle growth. Bull Cancer (Paris) 93:E39-E43.
5. Pederson T. 2007. Ribosomal protein mutations in Diamond- Blackfan anemia: might they operate upstream from protein synthesis? FASEB J 21:3442-3445.
6. Liu JM, Ellis SR. 2006. Ribosomes and marrow failure: coincidental association or molecular paradigm? Blood 107: 4583-4588.
7. Oliver ER, Saunders TL, Tarle SA, et al. 2004. Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse minute. Development 131:3907-3920.
8. Matsson H, Davey EJ, Draptchinskaia N, et al. 2004. Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation. Mol Cell Biol 24:4032-4037.
9. Panic L, Tamarut S, Sticker-Jantscheff M, et al. 2006. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26:8880-8891.
10. Kirn-Safran CB, Oristian DS, Focht RJ, et al. 2007. Global 23, growth deficiencies in mice lacking the ribosomal protein HIP/ RPL29. Dev Dyn 236:447-460.
11. DeLabre ML, Kessl J, Karamanou S, et al. 2002. RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling. Biochim Biophys Acta 1574:255-261.
12. Price C, Herman BC, Lufkin T, et al. 2005. Genetic variation in bone growth patterns defines adult mouse bone fragility. J. Bone Miner Res 20:1983-1991.
13. Jepsen KJ, Hu B, Tommasini SM, et al. 2007. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mamm Genome 18:492-507.
14. Alippi RM, Meta MD, Bozzini C, et al. 2002. Dynamics of recovery of morphometrical variables and pQCT-derived cortical bone properties after a short-term protein restriction in maturing rats. Growth Dev Aging 65:67-72.
15. Miller SA, Brown AJ, Farach-Carson MC, et al. 2003. HIP/ RPL29 down-regulation accompanies terminal chondrocyte differentiation. Differentiation 71:322-336.
16. Jepsen KJ, Pennington DE, Lee YL, et al. 2001. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res 16:1854-1862.
17. Schriefer JL, Robling AG, Warden SJ, et al. 2005. A comparison of mechanical properties derived from multiple skeletal sites in mice. J Biomech 38:467-475.
18. Olsen BR, Reginato AM, Wang W. 2000. Bone development. Annu Rev Cell Dev Biol 16:191-220.
19. Kronenberg HM. 2003. Developmental regulation of the growth plate. Nature 423:332-336.
20. Politz JC, Polena I, Trask I, et al. 2005. A non ribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin. Mol Biol Cell 16:3401-3410.
21. Tommasini SM, Nasser P, Jepsen KJ. 2007. Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties. Bone 40:498-505.
22. Wallace JM, Rajachar RM, Allen MR, et al. 2007. Exercise-induced changes in the cortical bone of growing mice are bone-and gender-specific. Bone 40:1120-1127.
23. Akhter MP, Wells DJ, Short SJ, et al. 2004. Bone bio-mechanical properties in LRP5 mutant mice. Bone 35:162-169.
24. Maloul A, Rossmeier K, Mikic B, et al. 2006. Geometric and material contributions to whole bone structural behavior in GDF-7-deficient mice. Connect Tissue Res 47:157-162.
25. Martin RB, Boardman DL. 1993. The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech 26:1047-1054.
26. Boskey AL. 2006. Assessment of bone mineral and matrix using backscatter electron imaging and FTIR imaging. Curr Osteoporosis Rep 4:71-75.
27. Camacho NP, Rinnerthaler S, Paschalis EP, et al. 1999. Complementary information on bone ultrastructure from scanning small angle X-ray scattering and Fourier-transform infrared micro spectroscopy. Bone 25:287-293.