MicroRNA-19b targets Mfn1 to inhibit Mfn1-induced apoptosis in osteosarcoma cells

Neoplasma

Volumn 61, Issue 3, 2014, Pages 265-273

  Li, X ^a   Wang, F S ^a   Wu, Z Y ^a   Lin, J L ^a   Lan, W B ^a   Lin, J H ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; Mfn1; MiR 19b; Osteosarcoma

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; MICRORNA; MICRORNA 19B; MITOFUSIN 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; NICK END LABELING; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; APOPTOSIS; BONE NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP PHOSPHOHYDROLASES; HUMANS; MICRORNAS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEOPLASM INVASIVENESS; OSTEOSARCOMA;

EID: 84902344809     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2014_034     Document Type: Article

References (31)

1. NISWANDER LM, KIM SY. Stratifying osteosarcoma: minimizing and maximizing therapy. Curr Oncol Rep 2010; 12: 266-270. http://dx.doi.org/10.1007/s11912-010-0106-3
2. OTTAVIANI G, JAFFE N. Te epidemiologyofosteosarcoma. Cancer Treat Res 2009; 152: 3-13.
3. ZHANG X, YU H, LOU JR, ZHENG J, ZHU H, et al. Micro-RNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem 2011; 286: 1429-1435. http://dx.doi.org/10.1074/jbc.M110.146530
4. HUANG G, NISHIMOTO K, ZHOU Z, HUGHES D, Klein-Erman ES. Mir-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. Cancer Res 2012; 72: 908-916. http://dx.doi.org/10.1158/0008-5472.CAN-11-1460
5. BAUMHOER D, ZILLMER S, UNGER K, ROSEMANN M, ATKINSON MJ, et al. MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. Cancer Genet 2012; 205: 212-219. http://dx.doi.org/10.1016/j.cancergen.2012.03.001
6. XU Y, FANG F, ZHANG J, JOSSON S, ST CLAIR WH, et al. Mir-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes. PLoS One 2010; 5: e14356. http://dx.doi.org/10.1371/journal. pone.0014356
7. SUGIOKA R, SHIMIZU S, TSUJIMOTO Y. FZO1, a protein involved in mitochondrial fusion, inhibits apoptosis. J Biol Chem 2004; 279: 52726-52734. http://dx.doi.org/10.1074/jbc. M408910200
8. ISHIHARA N, EURA Y, MIHARA K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J Cell Sci 2004; 117: 6535-6546. http://dx.doi.org/10.1242/jcs.01565
9. SANTEL A, FRANK S, GAUME B, HERRLER M, YOULE RJ, et al. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci 2003; 116: 2763-2774. http://dx.doi.org/10.1242/jcs.00479
10. RYU SW, CHOI K, PARK JH, PARK YM, KIM S, et al. Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial trans-location, in a GTPase-dependent manner. Cancer Lett 2012; 323: 62-68. http://dx.doi.org/10.1016/j.canlet.2012.03.038
11. JIN B, FU G, PAN H, CHENG X, ZHOU L, et al. Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma. Med Oncol 2011; 28 Suppl 1: S373-S380. http://dx.doi.org/10.1007/s12032-010-9662-5
12. WANG W, ZHOU D, WEI J, WU Z, CHENG X, et al. Hepatitis B virus X protein inhibits p53-mediated upregulation of mitofusin-2 in hepatocellular carcinoma cells. Biochem Biophys Res Commun 2012; 421: 355-360. http://dx.doi.org/10.1016/j.bbrc.2012.04.015
13. YU J, OHUCHIDA K, MIZUMOTO K, FUJITA H, NAKATA K, et al. MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. Cancer Biol Ter 2010; 10: 748-757. http://dx.doi.org/10.4161/cbt.10.8.13083
14. XU XM, WANG XB, CHEN MM, LIU T, LI YX, et al. MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. Cancer Lett 2012; 322: 148-158. http://dx.doi.org/10.1016/j.canlet.2012.02.038
15. YANG J, ZHANG W. New molecular insights into osteosar-coma targeted therapy. Curr Opin Oncol 2013; 25: 398-406. http://dx.doi.org/10.1097/CCO.0b013e3283622c1b
16. GOUGELET A, PISSALOUX D, BESSE A, PEREZ J, DUC A, et al. Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response. Int J Cancer 2011; 129: 680-690. http://dx.doi.org/10.1002/ijc.25715
17. ESSA S, DENZER N, MAHLKNECHT U, KLEIN R, Coll-Not EM, et al. Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma. Clin Epigenetics 2010; 1: 7-11. http://dx.doi.org/10.1007/s13148-010-0001-7
18. HE J, ZHANG JF, YI C, LV Q, XIE WD, et al. MiRNA-mediated functional changes through co-regulating function related genes. PLoS One 2010; 5: e13558. http://dx.doi.org/10.1371/journal.pone.0013558
19. JETHWA K, WEI J, MCENERY K, HEIMBERGER AB. MiRNA-mediated immune regulation and immunothera-peutic potential in glioblastoma. Clin Investig (Lond) 2011; 1: 1637-1650. http://dx.doi.org/10.4155/cli.11.159
20. JONES KB, SALAH Z, DEL MARE S, GALASSO M, GAUDIO E, et al. miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res 2012; 72: 1865-1877. http://dx.doi.org/10.1158/0008-5472.CAN-11-2663
21. MAIRE G, MARTIN JW, YOSHIMOTO M, Chilton-Macneill S, ZIELENSKA M, et al. Analysis of miRNA-gene expression-genomic profiles reveals complex mechanisms of microRNA deregulation in osteosarcoma. Cancer Genet 2011; 204: 138-46. http://dx.doi.org/10.1016/j.cancergen.2010.12.012
22. IORIO MV, VISONE R, DI LEVA G, DONATI V, PETROCCA F, et al. MicroRNA signatures in human ovarian cancer. Cancer Res 2011; 67: 8699-8707. http://dx.doi.org/10.1158/0008-5472. CAN-07-1936
23. GAROFALO M, QUINTAVALLE C, DI LEVA G, ZANCA C, ROMANO G, et al. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene 2008; 27: 3845-3855. http://dx.doi.org/10.1038/onc.2008.6
24. HARTING MT, BLAKELY ML. Management of osteosarcoma pulmonary metastases. Semin Pediatr Surg 2006; 15: 25-29. http://dx.doi.org/10.1053/j.sempedsurg.2005.11.005
25. CALDAS C, BRENTON JD. Sizing up miRNA as cancer genes. Nat Med 2005; 11 (7): 712-714. http://dx.doi.org/10.1038/nm0705-712
26. RANJI N, SADEGHIZADEH M, SHOKRGOZAR MA, BAKHSHANDEH B, Karimipour M, et al. MiR-17-92 cluster: an apoptosis inducer or proliferation enhancer. Mol Cell Biochem 2013; 380: 229-38. http://dx.doi.org/10.1007/s11010-013-1678-7
27. MATSUBARA H, TAKEUCHI T, NISHIKAWA E, Yana-Gisawa K, HAYASHITA Y, et al. Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 2007; 26: 6099-6105. http://dx.doi.org/10.1038/sj.onc.1210425
28. YAN HL, XUE G, MEI Q, WANG YZ, DING FX, et al. Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J 2009; 28: 2719-2732. http://dx.doi.org/10.1038/emboj.2009.214
29. PERFETTINI JL, ROUMIER T, KROEMER G. Mitochon-drial fusion and fission in the control of apoptosis. Trends Cell Biol 2005; 15: 179-83. http://dx.doi.org/10.1016/j.tcb.2005.02.005
30. XIA Y, WU Y, HE X, GONG J, QIU F. Effects of mitofusin-2 gene on cell proliferation and chemotherapy sensitivity of MCF-7. J Huazhong Univ Sci Technolog Med Sci 2008; 28: 185-189. http://dx.doi.org/10.1007/s11596-008-0218-2
31. MA L, LIU Y, GENG C, QI X, JIANG J. Estrogen receptor beta inhibits estradiol-induced proliferation and migration of MCF-7 cells through regulation of mitofusin 2. Int J Oncol 2013; 42: 1993-2000.