Sinonasal inhalation of dornase alfa administered by vibrating aerosol to cystic fibrosis patients: A double-blind placebo-controlled cross-over trial

Journal of Cystic Fibrosis

Volumn 13, Issue 4, 2014, Pages 461-470

  Mainz, Jochen G ^a   Schien, Claudia ^a   Schiller, Isabella ^a   Schädlich, Katja ^a   Koitschev, Assen ^b   Koitschev, Christiane ^c   Riethmüller, Joachim ^c   Graepler Mainka, Uta ^c   Wiedemann, Bärbel ^d   Beck, James F ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b Department of Paediatric Otorhinolaryngology Olgahospital Stuttgart ^*  (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Chronic rhinosinusitis; Cystic fibrosis; Dornase alfa; Pari Sinus ; Sinonasal inhalation; SNOT 20

Indexed keywords

DORNASE ALFA; PLACEBO; AEROSOL; DEOXYRIBONUCLEASE I; RECOMBINANT PROTEIN;

ADOLESCENT; ADULT; AEROSOL; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYSTIC FIBROSIS; DOUBLE BLIND PROCEDURE; DRUG ADMINISTRATION ROUTE; FEMALE; HUMAN; MALE; MEDICAL INFORMATICS; MEDICAL NEBULIZER; OUTCOME ASSESSMENT; PARANASAL SINUS; PILOT STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINONASAL INHALATION; TREATMENT DURATION; ADMINISTRATION AND DOSAGE; DOSE RESPONSE; INTRANASAL DRUG ADMINISTRATION; MIDDLE AGED; VIBRATION; YOUNG ADULT;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; AEROSOLS; AGED; CHILD; CROSS-OVER STUDIES; CYSTIC FIBROSIS; DEOXYRIBONUCLEASE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PARANASAL SINUSES; PILOT PROJECTS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; VIBRATION; YOUNG ADULT;

EID: 84902328031     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2014.02.005     Document Type: Article

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