Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise

Brain, Behavior, and Immunity

Volumn 39, Issue , 2014, Pages 152-159

  Brown, Frankie F ^a   Bigley, Austin B ^a,b   Sherry, Chris ^a   Neal, Craig M ^a   Witard, Oliver C ^a   Simpson, Richard J ^a,b   Galloway, Stuart D R ^a  

^a UNIVERSITY OF STIRLING   (United Kingdom)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

Immunosurveillance; Trained; Untrained

Indexed keywords

CD28 ANTIGEN; CD57 ANTIGEN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL AGING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; EXERCISE; EXERCISE TEST; EXHAUSTION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE FUNCTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEROLOGY; SEX DIFFERENCE; SEX RATIO; SOCCER; T LYMPHOCYTE; T LYMPHOCYTE REDISTRIBUTION; T LYMPHOCYTE SUBPOPULATION; TREADMILL EXERCISE; ADOLESCENT; ATHLETE; IMMUNOLOGY; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; ATHLETES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; MALE; SEX FACTORS; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84902315543     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2013.10.031     Document Type: Article

References (43)

1. Akbar A.N., Henson S.M. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?. Nat. Rev. Immunol. 2011, 11:289-295.
2. Anane L.H., Edwards K.M., Burns V.E., Drayson M.T., Riddell N.E., van Zanten J.J., Wallace G.R., Mills P.J., Bosch J.A. Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion. Brain Behav. Immun. 2009, 23:823-829.
3. Appay V., Dunbar P.R., Callan M., Klenerman P., Gillespie G.M., Papagno L., Ogg G.S., King A., Lechner F., Spina C.A., Little S., Havlir D.V., Richman D.D., Gruener N., Pape G., Waters A., Easterbrook P., Salio M., Cerundolo V., McMichael A.J., Rowland-Jones S.L. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002, 8:379-385.
4. Appay V., van Lier R.A., Sallusto F., Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 2008, 73:975-983.
5. Athreya B.H., Pletcher J., Zulian F., Weiner D.B., Williams W.V. Subset-specific effects of sex hormones and pituitary gonadotropins on human lymphocyte proliferation in vitro. Clin. Immunol. Immunopathol. 1993, 66:201-211.
6. Betz M., Fox B.S. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 1991, 146:108-113.
7. Borg G. Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling strength test. Int. J. Sports Med. 1982, 3:153-158.
8. Borg G.A. Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 1982, 14:377-381.
9. Bosch J.A., Berntson G.G., Cacioppo J.T., Dhabhar F.S., Marucha P.T. Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression: a potential pathway linking immunologic reactivity to cardiovascular disease. Brain Behav. Immun. 2003, 17:251-259.
10. Bouman A., Schipper M., Heineman M.J., Faas M.M. Gender difference in the non-specific and specific immune response in humans. Am. J. Reprod. Immunol. 2004, 52:19-26.
11. Brenchley J.M., Karandikar N.J., Betts M.R., Ambrozak D.R., Hill B.J., Crotty L.E., Casazza J.P., Kuruppu J., Migueles S.A., Connors M., Roederer M., Douek D.C., Koup R.A. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003, 101:2711-2720.
12. Campbell J.P., Guy K., Cosgrove C., Florida-James G.D., Simpson R.J. Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain Behav. Immun. 2008, 22:375-380.
13. Campbell J.P., Riddell N.E., Burns V.E., Turner M., van Zanten J.J., Drayson M.T., Bosch J.A. Acute exercise mobilises CD8+ T lymphocytes exhibiting an effector-memory phenotype. Brain Behav. Immun. 2009, 23:767-775.
14. Cutolo M., Sulli A., Seriolo B., Accardo S., Masi A.T. Estrogens, the immune response and autoimmunity. Clin. Exp. Rheumatol. 1995, 13:217-226.
15. Dhabhar F.S., Malarkey W.B., Neri E., McEwen B.S. Stress-induced redistribution of immune cells-from barracks to boulevards to battlefields: a tale of three hormones. Psychoneuroendocrino 2012, 37:1345-1368.
16. Effros R.B. Replicative senescence of CD8 T cells: potential effects on cancer immune surveillance and immunotherapy. Cancer Immunol. Immunother. 2004, 53:925-933.
17. Giltay E.J., Fonk J.C., von Blomberg B.M., Drexhage H.A., Schalkwijk C., Gooren L.J. In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans. J. Clin. Endocrinol. Metab. 2000, 85:1648-1657.
18. Hong S., Johnson T.A., Farag N.H., Guy H.J., Matthews S.C., Ziegler M.G., Mills P.J. Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals. J. Appl. Physiol. 2005, 98:1057-1063.
19. Ibegbu C.C., Xu Y.X., Harris W., Maggio D., Miller J.D., Kourtis A.P. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. J. Immunol. 2005, 174:6088-6094.
20. Jones A.M., Doust J.H. The conconi test in not valid for estimation of the lactate turnpoint in runners. J. Sports Sci. 1997, 15:385-394.
21. Kjaer M., Christensen N.J., Sonne B., Richter E.A., Galbo H. Effect of exercise on epinephrine turnover in trained and untrained male subjects. J. Appl. Physiol. 1985, 59:1061-1067.
22. Koch S., Larbi A., Ozcelik D., Solana R., Gouttefangeas C., Attig S., Wikby A., Strindhall J., Franceschi C., Pawelec G. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann. N.Y. Acad. Sci. 2007, 1114:23-35.
23. Kruger K., Lechtermann A., Fobker M., Volker K., Mooren F.C. Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms. Brain Behav. Immun. 2008, 22:324-338.
24. Landmann R. Beta-adrenergic receptors in human leukocyte subpopulations. Eur. J. Clin. Invest. 1992, 22(Suppl. 1):30-36.
25. Lee S., Kim J., Jang B., Hur S., Jung U., Kil K., Na B., Lee M., Choi Y., Fukui A., Gilman-Sachs A., Kwak-Kim J.Y. Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women. J. Immunol. 2010, 185:756-762.
26. Oertelt-Prigione S. Immunology and the menstrual cycle. Autoimmun. Rev. 2012, 11:A486-A492.
27. Pawelec G., Derhovanessian E., Larbi A., Strindhall J., Wikby A. Cytomegalovirus and human immunosenescence. Rev. Med. Virol. 2009, 19:47-56.
28. Romero P., Zippelius A., Kurth I., Pittet M.J., Touvrey C., Iancu E.M., Corthesy P., Devevre E., Speiser D.E., Rufer N. Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J. Immunol. 2007, 178:4112-4119.
29. Simpson R.J. Aging, persistent viral infections, and immunosenescence: can exercise "make space"?. Exerc. Sport Sci. Rev. 2011, 39:23-33.
30. Simpson R.J., Cosgrove C., Ingram L.A., Florida-James G.D., Whyte G.P., Pircher H., Guy K. Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain Behav. Immun. 2008, 22:544-551.
31. Simpson R.J., Florida-James G.D., Cosgrove C., Whyte G.P., Macrae S., Pircher H., Guy K. High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. J. Appl. Physiol. 2007, 103:396-401.
32. Simpson R.J., Florida-James G.D., Whyte G.P., Guy K. The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53. Eur. J. Appl. Physiol. 2006, 97:109-121.
33. Spielmann G., McFarlin B.K., O'Connor D.P., Smith P.J., Pircher H., Simpson R.J. Aerobic fitness is associated with lower proportions of senescent blood T-cells in man. Brain Behav. Immun. 2011, 25:1521-1529.
34. Tam A., Morrish D., Wadsworth S., Dorscheid D., Man S.F., Sin D.D. The role of female hormones on lung function in chronic lung diseases. BMC Women's Health 2011, 11:24.
35. Tchkonia T., Morbeck D.E., Von Z.T., Van D.J., Lustgarten J., Scrable H., Khosla S., Jensen M.D., Kirkland J.L. Fat tissue, aging, and cellular senescence. Aging Cell 2010, 9:667-684.
36. Tengstrand B., Ahlmen M., Hafstrom I. The influence of sex on rheumatoid arthritis: a prospective study of onset and outcome after 2years. J. Rheumatol. 2004, 31:214-222.
37. Turner J.E., Aldred S., Witard O.C., Drayson M.T., Moss P.M., Bosch J.A. Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain Behav. Immun. 2010, 24:1362-1370.
38. Turner J.E., Campbell J.P., Edwards K.M., Howarth L.J., Pawelec G., Aldred S., Moss P., Drayson M.T., Burns V.E., Bosch J.A. Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age (Dordr.) 2013, 10.1007/s11357-013-9557-4.
39. Vinten J., Galbo H. Effect of physical training on transport and metabolism of glucose in adipocytes. Am. J. Physiol. 1983, 244:E129-E134.
40. Voehringer D., Koschella M., Pircher H. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectin like receptor G1 (KLRG1). Blood 2002, 100:3698-3702.
41. Witard O.C., Turner J.E., Jackman S.R., Tipton K.D., Jeukendrup A.E., Kies A.K., Bosch J.A. High-intensity training reduces CD8+ T-cell redistribution in response to exercise. Med. Sci. Sports Exerc. 2012, 44:1689-1697.
42. Xu D., Erickson S., Szeps M., Gruber A., Sangfelt O., Einhorn S., Pisa P., Grander D. Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells. Blood 2000, 96:4313-4318.
43. Yan J., Greer J.M., Hull R., O'Sullivan J.D., Henderson R.D., Read S.J., McCombe P.A. The effect of ageing on human lymphocyte subsets: comparison of males and females. Immun. Ageing 2010, 7:4.