Changes in vitamin D-related mineral metabolism after induction with anti-tumor necrosis factor-α therapy in crohn's disease

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 6, 2014, Pages

  Augustine, Marianne V ^a   Leonard, Mary B ^a,b   Thayu, Meena ^a   Baldassano, Robert N ^a,b   De Boer, Ian H ^c   Shults, Justine ^a,b   Denson, Lee A ^d   DeBoer, Mark D ^e   Herskovitz, Rita ^a   Denburg, Michelle R ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24,25 DIHYDROXYVITAMIN D; C REACTIVE PROTEIN; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; CALCIUM; FIBROBLAST GROWTH FACTOR 23; INFLIXIMAB; INTERLEUKIN 6; PARATHYROID HORMONE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VITAMIN D BINDING PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CROHN DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FOLLOW UP; HUMAN; INDUCTION CHEMOTHERAPY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MINERAL METABOLISM; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; OUTCOME ASSESSMENT; PEDIATRIC CROHN DISEASE ACTIVITY INDEX; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; VITAMIN SUPPLEMENTATION; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, MONOCLONAL; CHILD; CHILD, PRESCHOOL; CROHN DISEASE; FEMALE; HUMANS; INDUCTION CHEMOTHERAPY; MALE; MINERALS; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN D; YOUNG ADULT;

EID: 84902310935     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3846     Document Type: Article

References (28)

1. Levin AD, Wadhera V, Leach ST, et al. Vitamin D deficiency in children with inflammatory bowel disease. Digest Dis Sci. 2011;56: 830-836.
2. Pappa HM, Gordon CM, Saslowsky TM, et al. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics. 2006;118:1950-1961.
3. Sentongo TA, Semaeo E J, Stettler N, PiccoliDA,Stallings VA, Zemel BS. VitaminDstatus in children, adolescents, and young adults with Crohn disease. Am J Clin Nutr. 2002;76:1077-1081.
4. Sylvester FA, Wyzga N, Hyams JS, et al. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:42-50.
5. Canaff L, Hendy GN. Calcium-sensin g receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1-. Role of the NF-B pathway and-B elements. J Biol Chem. 2005; 280:14177-14188.
6. Canaff L, Zhou X, Hendy GN. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem. 2008;283:13586-13600.
7. Liu N, Nguyen L, Chun RF, et al. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology. 2008;149:4799-4808.
8. Uno JK, Kolek OI, Hines ER, et al. The role of tumor necrosis factor-in down-regulation of osteoblast Phex gene expression in experimental murine colitis. Gastroenterology. 2006;131:497-509.
9. Inoue Y, Segawa H, Kaneko I, et al. Role of the vitamin D receptor in FGF23 action on phosphate metabolism. Biochem J. 2005;390: 325-331.
10. Chun RF, Lauridsen AL, Suon L, et al. Vitamin D-binding protein directs monocyte responses to 25-hydroxy-and 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab. 2010;95:3368-3376.
11. Jeffery LE, Wood AM, Qureshi OS, et al. Availab ility of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol. 2012;189:5155-5164.
12. Prosnitz AR, Leonard MB, Shults J, et al. Changes in vitamin D and parathyroid hormone metabolism in incident pediatric Crohn's disease. Inflamm Bowel Dis. 2013;19:45-53.
13. El-HodhodMA,HamdyAM,AbbasAA,Moftah SG,RamadanAA. Fibroblast growth factor 23 co ntributes to diminished bone mineral density in childhood inflammatory bowel disease. BMC Gastroenterol. 2012;12:44.
14. Hyams JS, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr. 1991;12:439-447.
15. Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centers for Disease Control and Prevention 2000 growth charts for th e United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics. 2002;109:45-60.
16. Hollis BW Quantitation of 25-hydroxyvitamin D and 1,25- dihydroxyvitaminDby radioimmunoassay using radioiodinated tracers Methods Enzymol. 1997 282 174-186.
17. Clive DR, Sudhaker D, Giacherio D, et al. Analytical and clinical validation of a radioimmunoassay for the m easurement of 1,25 dihydroxy vitamin D. Clin Biochem. 2002;35:517-521.
18. Bosworth CR, Levin G, Robinson-Cohen C, et al. The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D c atabolism, is reduced in chronic kidney disease. Kidney Int. 2012;82:693-700.
19. Serum-calcium. Lancet. 1979;1:858-859.
20. Schwartz GJ, Haycock GB, Edelmann CM Jr. , Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58:259-263.
21. Levey AS, Stevens LA, Schmid CH, et al.Anew equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604-612.
22. Bikle DD, Gee E, Halloran B, Kowalsk i MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986;63:954-959.
23. Bikle DD, Siiteri PK, Ryzen E, Haddad JG. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab. 1985;61:969-975.
24. Ebert R, Jovanovic M, Schneider D, et al. Down-regulation by nuclear factor-B of human 25-hydroxyvitamin D3 1-hydroxylase promoter. Mol Endocrinol. 2004;18:2440-2450.
25. Oelzner P, Muller A, Deschner F, et al. Relationship between disease activity and serum levels of vitaminDmetabolites and PTH in rheumatoid arthritis. Calcif Tissue Int. 1998;62:193-198.
26. Antonoglou G, Knuuttila M, Niemela O, et al. Serum 1,25(OH)D level increases after elimination of periodontal inflammation in T1DM subjects. J Clin Endocrinol Metab. 2013;98(10):3999-4005.
27. Abreu MT, Kanto rovich V, Vasiliauskas EA, et al. Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density. Gut. 2004;53:1129-1136.
28. Oikonomou KA, Orfanidou TI, Vlychou MK, et al. Lower fibroblast growth factor 23 levels in young adults with Crohn Disease as a possible secondary compensatory effect on the disturbance of bon e and mineral metabolism. J Clin Densitom. 2014;17(1):177-184.