Astragalus membranaceus up-regulate Cosmc expression and reverse IgA dys-glycosylation in IgA nephropathy

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Ji, Ling ^a   Chen, XiaoLei ^a   Zhong, Xiang ^b   Li, Zi ^a   Yang, Lichuan ^a   Fan, Junming ^a,c   Tang, Wanxing ^a   Qin, Wei ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Astragalus membranaceus; Cosmc; Glycosylation; IgA nephropathy

Indexed keywords

CHAPERONE; COSMC PROTEIN; HERBACEOUS AGENT; IMMUNOGLOBULIN A; LIPOPOLYSACCHARIDE; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTRAGALUS MEMBRANACEUS; B LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; DYS GLYCOSYLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GLYCOSYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOGLOBULIN A NEPHROPATHY; LECTIN BINDING; LOW DRUG DOSE; LYMPHOCYTE CULTURE; MALE; PERIPHERAL LYMPHOCYTE; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADOLESCENT; ADULT; ASTRAGALUS MEMBRANACEUS; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; LIPOPOLYSACCHARIDES; MALE; MOLECULAR CHAPERONES; PLANT EXTRACTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION; YOUNG ADULT;

EID: 84902302552     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-195     Document Type: Article

References (15)

1. Lai KN. Pathogenesis of IgA nephropathy. Nat Rev Nephrol 2012, 8:275-283.
2. Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB, Wyatt RJ, Scolari F, Mestecky J, Gharavi AG, Julian BA. The pathophysiology of IgA nephropathy. J Am Soc Nephrol 2011, 22:1795-1803.
3. Qin W, Zhou Q, Yang LC, Li Z, Su BH, Luo H, Fan JM. Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy. J Intern Med 2005, 258:467-477.
4. Li M, Wang W, Xue J, Gu Y, Lin S. Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol 2011, 133:412-419.
5. Li SM, Yan JX, Yang L. Effects of Astragalus injection on renal tubular function in patients with IgA nephropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi 2006, 26:504-507.
6. Qin W, Zhong X, Fan JM, Zhang YJ, Liu XR, Ma XY. External suppression causes the low expression of the Cosmc gene in IgA nephropathy. Nephrol Dial Transplant 2008, 23:1608-1614.
7. Xie LS, Qin W, Fan JM, Huang J, Xie XS, Li Z. The role of C1GALT1C1 in lipopolysaccharide-induced IgA1 aberrant O-glycosylation in IgA nephropathy. Clin Invest Med 2010, 33:E5-E13.
8. Xie L, Tan C, Fan J, Fu P, Tang Y, Tao Y, Qin W. Mycophenolic acid reverses IgA1 aberrant glycosylation through up-regulating Cosmc expression in IgA nephropathy. Int Urol Nephrol 2013, 45:571-579.
9. Giannakakis K, Feriozzi S, Perez M, Faraggiana T, Muda AO. Aberrantly glycosylated IgA1 in glomerular immune deposits of IgA nephropathy. J Am Soc Nephrol 2007, 18:3139-3146.
10. Zhao N, Hou P, Lv J, Moldoveanu Z, Li Y, Kiryluk K, Gharavi AG, Novak J, Zhang H. The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression. Kidney Int 2012, 82:790-796.
11. Meng L, Qu L, Tang J, Cai SQ, Wang H, Li X. A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. Vascul Pharmacol 2007, 47:174-183.
12. Zuo C, Xie XS, Qiu HY, Deng Y, Zhu D, Fan JM. Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction. J Zhejiang Univ Sci B 2009, 10:380-390.
13. Peng XJ, Wu XC, Zhang GZ, Yi ZW, Zheng WM, He XJ, Mo SH, Tan H. Regulatory effect of Astragalus membranaceus on the immune disorder in rats with IgA nephropathy. Zhonghua Er Ke Za Zhi 2008, 46:55-60.
14. Cho WC, Leung KN. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol 2007, 113:132-141.
15. Floege J, Eitner F. Current therapy for IgA nephropathy. J Am Soc Nephrol 2011, 22:1785-1794.