Titer and product affect the distribution of gene expression after intraputaminal convection-enhanced delivery

Stereotactic and Functional Neurosurgery

Volumn 92, Issue 3, 2014, Pages 182-194

  Emborg, Marina E ^a,b,c   Hurley, Samuel A ^d   Joers, Valerie ^a,b   Tromp, Do P M ^b,d   Swanson, Christine R ^a,b   Ohshima Hosoyama, Sachiko ^a   Bondarenko, Viktorya ^a   Cummisford, Kyle ^a   Sonnemans, Marc ^e   Hermening, Stephan ^e   Blits, Bas ^e   Alexander, Andrew L ^b,d  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c University of Wisconsin Madison   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIQURE   (Netherlands)

Author keywords

Convection enhanced delivery; Gene expression; Intracerebral brain therapy; Parkinson's disease

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; PARVOVIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENO ASSOCIATED VIRUS 5; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; CONTROLLED STUDY; DRUG DISTRIBUTION; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; INJECTION SITE; MALE; NONHUMAN; PARKINSON DISEASE; PUTAMEN; RHESUS MONKEY; SUBSTANTIA NIGRA PARS COMPACTA; SUBSTANTIA NIGRA PARS RETICULATA; VIRAL GENE DELIVERY SYSTEM; ADMINISTRATION AND DOSAGE; ANIMAL; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; SURGERY; THERMODYNAMICS; ADULT; GENE PRODUCT; HAPLORHINI; INOCULATION; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; IRRADIATION; NERVE CELL; PROTEIN EXPRESSION; SUBSTANTIA NIGRA; VIRUS DETECTION;

ANIMALS; CONVECTION; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; INFUSIONS, INTRAVENTRICULAR; MACACA MULATTA; MALE; PUTAMEN;

EID: 84902302537     PISSN: 10116125     EISSN: 14230372     Source Type: Journal    
DOI: 10.1159/000360584     Document Type: Article

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