Phenylephrine activates eNOS Ser1177 phosphorylation and nitric oxide signaling in renal hypertensive rat aorta

European Journal of Pharmacology

Volumn 738, Issue , 2014, Pages 192-199

  Silva, Bruno R ^a   Pernomian, Laena ^a   Grando, Marcella D ^a   Bendhack, Lusiane M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Endothelium; eNOS phosphorylation; Phenylephrine; Renovascular hypertension

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALPHA 1 ADRENERGIC RECEPTOR; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; NITRIC OXIDE; PHENYLEPHRINE; PHOSPHODIESTERASE INHIBITOR; PROTEIN KINASE B; SERINE;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RENOVASCULAR HYPERTENSION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SOLUBILITY; VASOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; AORTA; CYCLIC GMP; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUANYLATE CYCLASE; HYPERTENSION, RENOVASCULAR; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHENYLEPHRINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SERINE; SIGNAL TRANSDUCTION; SOLUBILITY; VASOCONSTRICTION;

EID: 84902301836     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.05.040     Document Type: Article

References (28)

1. D. Bonaventura, C.N. Lunardi, G.J. Rodrigues, M.A. Neto, J.A. Vercesi, R.G. De Lima, R.S. Da Siva, and L.M. Bendhack Endothelium negatively modulates the vascular relaxation induced by nitric oxide donor, due to uncoupling NO synthase J. Inorg. Biochem. 103 2009 1366 1374
2. + channel activation Clin. Exp. Pharmacol. Physiol. 32 2005 478 481 (Pubitemid 40780279)
3. H. Cai, Z. Li, M.E. Davis, W. Kanner, D.G. Harrison, and S.C. Dudley Jr Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide Mol. Pharmacol. 63 2 2003 325 331 (Pubitemid 36158367)
4. G.E. Callera, W.A. Varanda, and L.M. Bendhack Impaired relaxation to acetylcholine in 2K-1C hypertensive rat aortas involves changes in membrane hyperpolarization instead of an abnormal contribution of endothelial factors Gen. Pharmacol. 34 2000 379 389 (Pubitemid 32718753)
5. M.M. Castro, E. Rizzi, L. Figueiredo-Lopes, K. Fernandes, L.M. Bendhack, D.L. Pitol, R.F. Gerlach, and J.E. Tanus-Santos Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats Atherosclerosis 198 2008 320 331 (Pubitemid 351707391)
6. C.A. Costa, T.A.S. Amaral, L.C.R.M. Carvalho, D.T. Ognibene, A.F.E. da Silva, M.B. Moss, S.S. Valença, R.S. De Moura, and A.C. Resende Antioxidant treatment with tempol and apocynin prevents endothelial dysfunction and development of renovascular hypertension Am. J. Hypertens. 22 12 2009 1242 1249
7. H.M. DeLisser, M. Christofidou-Solomidou, R.M. Strieter, M.D. Burdick, C.S. Robinson, R.S. Wexler, J.S. Kerr, C. Garlanda, J.R. Merwin, J.A. Madri, and S.M. Albelda Involvement of endothelial PECAM-1/CD31 in angiogenesis Am. J. Pathol. 151 3 1997 671 677 (Pubitemid 27385598)
8. S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse, and A.M. Zeiher Activation of nitric oxide synthase in endothelial cells by akt dependent phosphorylation Nature 399 1999 601 605
9. +2/calmodulin- dependent endothelial nitric oxide synthase activity Circ. Res. 88 11 2001 E68 E75
10. S.H. Francis, J.L. Busch, and J.D. Corbin cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action Pharmacol. Rev. 62 2010 525 563
11. D. Fulton, J.P. Gratton, T.J. MCcabe, J. Fontana, Y. Fujio, K. Walsh, T.F. Franke, A. Papapetropoulos, and W.C. Sessa Regulation of endothelium-derived nitric oxide production by the protein kinase akt Nature 399 1999 597 601
12. R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial cells in the relaxation of arterial smooth by acetylcholine Nature 288 1980 373 376 (Pubitemid 11169009)
13. C. Gerassimou, A. Kotanidou, Z. Zhou, D.D.C. Simoes, C. Roussos, and A. Papapetropoulos Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species Br. J. Pharmacol. 150 2007 1084 1091 (Pubitemid 46625092)
14. 1- adrenergic receptor stimulation in rat thoracic aorta Br. J. Pharmacol. 145 2005 203 210 (Pubitemid 40756524)
15. L.J. Ignarro, G.M. Buga, K.S. Wood, R.E. Byrns, and G. Chaudhuri Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide Proc. Natl. Acad. Sci. USA 84 1987 9265 9269
16. S. Kerr, M.J. Brosnan, M. McIntyre, J.L. Reid, A.F. Dominiczak, and C.A. Hamilton Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium Hypertension 33 1999 1353 1358 (Pubitemid 29282653)
17. R.C. Looft-Wilson, S.E. Todd, C.A. Araj, S.M. Mutchler, and C.A.R. Goodell Alpha1-adrenergic-mediated eNOS phosphorylation in intact arteries Vasc. Pharmacol. 58 2013 112 117
18. L.J. McDonald, and F. Murad Nitric oxide and cGMP signaling Adv. Pharmacol. 34 1995 263 275
19. M. McIntyre, D.F. Bohr, and A.F. Dominiczak Endothelial function in hypertension: the role of superoxide anion Hypertension 34 1999 539 545 (Pubitemid 29496430)
20. 1A-adrenoceptor and elucidates its relationship to the other subtypes Br. J. Pharmacol. 158 2009 209 224
21. M. Nakane, K. Arai, S. Saheki, T. Kuno, W. Buechler, and F. Murad Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung J. Biol. Chem. 265 1990 16841 16845
22. E.B. Oliveira-Sales, D.S.A. Colombari, R.L. Davisson, S. Kasparov, A.E. Hirata, R.R. Campos, and J.F.R. Paton Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla Hypertension 56 2010 290 296
23. E.B. Oliveira-Sales, E.E. Nishi, B.A. Carillo, M.A. Boim, S. Miriam, M.S. Dolnikoff, C.T. Bergamaschi, and R.R. Campos Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension Am. J. Hypertens. 22 5 2009 484 492
24. R.M. Palmer, D.S. Ashton, and S. Moncada Vascular endothelial cells synthesize nitric oxide from L-arginine Nature 333 1988 664 666
25. S. Prasad, J. Wilkinson, and M.A. Gatzoulis Sildenafil in primary pulmonary hypertension New Engl. J. Med. 343 2000 1342
26. R.M. Rapoport, and F. Murad Agonist-induced endothelium dependent relaxation in rat thoracic aorta may be mediated through cGMP Circ. Res. 52 1983 352 357 (Pubitemid 13158751)
27. I.G. Rybalkina, X. Tang, and S.D. Rybalkin Multiple affinity states of cGMP specific phosphodiesterase for sildenafil inhibition defined by cGMP-dependent and cGMP-independent mechanisms Mol. Pharmacol. 77 2010 670 677
28. B.R. Silva, L. Pernomian, M.D. Grando, J.H. Amaral, J.E. Tanus-Santos, and L.M. Bendhack Hydrogen peroxide modulates phenylephrine-induced contractile response in renal hypertensive rat aorta Eur. J. Pharmacol. 721 2013 193 200