Upregulation HOXA10 homeobox gene in endometrial cancer: Role in cell cycle regulation

Medical Oncology

Volumn 31, Issue 7, 2014, Pages

  Zhang, Lin ^a   Wan, Yicong ^a   Jiang, Yi ^a   Ma, Jingjing ^a   Liu, Jinsong ^b   Tang, Weiwei ^a   Wang, Xinru ^a   Cheng, Wenjun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Endometrial cancer; Homeobox gene A10; p21

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; MESSENGER RNA; MYC PROTEIN; PROTEIN P16; PROTEIN P21; PROTEIN P27; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR HOXA10; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HOMEODOMAIN PROTEIN; HOXA10 PROTEIN, HUMAN;

ARTICLE; CANCER CELL; CELL CYCLE REGULATION; ENDOMETRIUM CANCER; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENE VECTOR; HUMAN; HUMAN CELL CULTURE; HUMAN TISSUE; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; ENDOMETRIUM TUMOR; GENETICS; METABOLISM; PATHOLOGY; REFERENCE VALUE; TUMOR CELL LINE; UPREGULATION;

CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; REFERENCE VALUES; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84902300715     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0052-2     Document Type: Article

References (27)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2012;62:10-29.
2. McGinnis W, Krumlauf R. Homeobox genes and axial patterning. Cell. 1992;68:283-302.
3. Amesse LS, Moulton R, Zhang YM, Pfaff-Amesse T. Expression of HOX gene products in normal and abnormal trophoblastic tissue. Gynecol Oncol. 2003;90:512-8.
4. Hsieh-Li HM, Witte DP, Weinstein M, Branford W, Li H, Small K, Potter SS. Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility. Development. 1995;121:1373-85.
5. Benson GV, Lim H, Paria BC, Satokata I, Dey SK, Maas RL. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development. 1996;122:2687-96. (Pubitemid 26326501)
6. Li H, Huang CJ, Choo KB. Expression of homeobox genes in cervical cancer. Gynecol Oncol. 2002;84:216-21. (Pubitemid 34136770)
7. Bowen NJ, Logani S, Dickerson EB, Kapa LB, Akhtar M, Benigno BB, McDonald JF. Emerging roles for PAX8 in ovarian cancer and endosalpingeal development. Gynecol Oncol. 2007;104:331-7. (Pubitemid 46135661)
8. Chu MC, Selam FB, Taylor HS. HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells. Cancer Biol Ther. 2004;3:568-72. (Pubitemid 41351131)
9. Yoshida H, Broaddus R, Cheng W, Xie S, Naora H. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition. Cancer Res. 2006;66:889-97. (Pubitemid 43165955)
10. Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9:153-66.
11. Del Bene F, Wittbrodt J. Cell cycle control by homeobox genes in development and disease. Semin Cell Dev Biol. 2005;16:449-60.
12. Andreazzoli M, Gestri G, Cremisi F, Casarosa S, Dawid IB, Barsacchi G. Xrx1 controls proliferation and neurogenesis in Xenopus anterior neural plate. Development. 2003;130:5143-54. (Pubitemid 37369674)
13. Smith RC, Branellec D, Gorski DH, Guo K, Perlman H, Dedieu JF, Pastore C, Mahfoudi A, Denefle P, Isner JM, Walsh K. p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Genes Dev. 1997;11:1674-89. (Pubitemid 27300593)
14. Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene. 2003;22:7942-9. (Pubitemid 37175859)
15. Taylor HS, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest. 1998;101:1379-84. (Pubitemid 28166835)
16. Toki T, Mori A, Shimizu M, Nikaido T, Fujii S. Localization of apoptotic cells within the human endometrium and correlation between apoptosis and p21 expression. Mol Hum Reprod. 1998;4:1157-64. (Pubitemid 28552800)
17. Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003;22:5208-19. (Pubitemid 37059602)
18. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer. 2009;9:400-14.
19. Liu S, Bishop WR, Liu M. Differential effects of cell cycle regulatory protein p21(WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapy. Drug Resist Updat. 2003;6:183-95. (Pubitemid 37129918)
20. Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, Golub TR. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci USA. 2000;97:3260-5. (Pubitemid 30183289)
21. Horiuchi A, Wang C, Kikuchi N, Osada R, Nikaido T, Konishi I. BRCA1 expression is an important biomarker for chemosensitivity: suppression of BRCA1 increases the apoptosis via upregulation of p53 and p21 during cisplatin treatment in ovarian cancer cells. Biomark Insights. 2007;1:49-59.
22. Svingen T, Tonissen KF. Hox transcription factors and their elusive mammalian gene targets. Heredity (Edinb). 2006;97:88-96. (Pubitemid 44341508)
23. Bromleigh VC, Freedman LP. p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev. 2000;14:2581-6.
24. Magnusson M, Brun AC, Miyake N, Larsson J, Ehinger M, Bjornsson JM, Wutz A, Sigvardsson M, Karlsson S. HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development. Blood. 2007;109:3687-96. (Pubitemid 46641717)
25. Ye L, Mayberry R, Lo CY, Britt KL, Stanley EG, Elefanty AG, Gargett CE. Generation of human female reproductive tract epithelium from human embryonic stem cells. PLoS ONE. 2011;6:e21136.
26. Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med. 2005;11:531-7. (Pubitemid 40685976)
27. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 1995;9:935-44.