Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Vandebriel, Rob J ^a   Tonk, Elisa C M ^a   de la Fonteyne Blankestijn, Liset J ^a   Gremmer, Eric R ^a   Verharen, Henny W ^a   van der Ven, Leo T ^a   van Loveren, Henk ^a   de Jong, Wim H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Benchmark dose; Immunosuppression; Keyhole limpet hemocyanin; Nanosilver; Repeated dose toxicity; T cell dependent antibody response

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; KEYHOLE LIMPET HEMOCYANIN; SILVER NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CELL COUNT; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; DRUG DOSE COMPARISON; IMMUNOTOXICITY; MALE; NANOTOXICOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SPLEEN CELL; SPLEEN WEIGHT; THYMUS; TREATMENT DURATION;

RATTUS;

ANIMALS; ANTIBODY FORMATION; BODY WEIGHT; BONE MARROW CELLS; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HEMOCYANIN; HEMOGLOBINS; INJECTIONS, INTRAVENOUS; LEUKOCYTES; MALE; METAL NANOPARTICLES; ORGAN SIZE; RATS; RATS, WISTAR; SILVER; SPLEEN; T-LYMPHOCYTES;

EID: 84902296031     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-11-21     Document Type: Article

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