Topical cyclosporine A in the treatment of dry eye: A systematic review and meta-analysis

Cornea

Volumn 33, Issue 7, 2014, Pages 760-767

  Zhou, Xiao Qing ^a   Wei, Rui Li ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

dry eye; meta analysis; topical cyclosporine

Indexed keywords

ARTIFICIAL TEAR; CYCLOSPORIN; CYCLOSPORIN A; PLACEBO; EYE DROPS; IMMUNOSUPPRESSIVE AGENT;

ANESTHESIA; DATA SYNTHESIS; DRUG EFFICACY; DRUG SAFETY; DRY EYE; FOLLOW UP; HUMAN; META ANALYSIS; MULTICENTER STUDY (TOPIC); OCULAR SURFACE DISEASE; OCULAR SURFACE DISEASE INDEX; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; SCHIRMER TEST; SCORING SYSTEM; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; DRY EYE SYNDROMES; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; CYCLOSPORINE; DRY EYE SYNDROMES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; OPHTHALMIC SOLUTIONS;

EID: 84902269276     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0000000000000123     Document Type: Review

References (31)

1. Perry HD, Donnenfeld ED. Dry eye diagnosis and management in 2004. Curr Opin Ophthalmol. 2004;15:299-304.
2. Schein OD, Muñoz B, Tielsch JM, et al. Prevalence of dry eye among the elderly. Am J Ophthalmol. 1997;124:723-728.
3. Hikichi T, Yoshida A, Fukui Y, et al. Prevalence of dry eye in Japanese eye centers. Graefes Arch Clin Exp Ophthalmol. 1995;233:555-558.
4. Caffery BE, Richter D, Simpson T, et al. CANDEES. The Canadian Dry Eye Epidemiology Study. Adv Exp Med Biol. 1998;438:805-806.
5. Lee AJ, Lee J, Saw SM, et al. Prevalence and risk factors associated with dry eye symptoms: a population based study in Indonesia. Br J Ophthalmol. 2002;86:1347-1351.
6. O'Brien PD, Collum LM. Dry eye: diagnosis and current treatment strategies. Curr Allergy Asthma Rep. 2004;4:314-319.
7. Pflugfelder SC, Tseng SC, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998;17:38-56.
8. Pflugfelder SC, Solomon A, Stern ME. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000;19:644-649.
9. Pflugfelder SC, Wilhelmus KR, Osato MS, et al. The autoimmune nature of aqueous tear deficiency. Ophthalmology. 1986;93:1513-1517.
10. Stern ME, Beuerman RW, Fox RI, et al. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589.
11. Laibovitz RA, Solch S, Andriano K, et al. Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. Cornea. 1993;12:315-323.
12. Power WJ, Mullaney P, Farrell M, et al. Effect of topical cyclosporin A on conjunctival T cells in patients with secondary Sjögren's syndrome. Cornea. 1993;12:507-511.
13. Moon JW, Lee HJ, Shin KC, et al. Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye. Korean J Ophthalmol. 2007;21:189-194.
14. Rao SN. Topical cyclosporine 0.05% for the prevention of dry eye disease progression. J Ocul Pharmacol Ther. 2010;26:157-164.
15. Gündüz K, Ozdemir O. Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjögren's syndrome. Acta Ophthalmol (Copenh). 1994;72:438-442.
16. Demiryay E, Yaylali V, Cetin EN, et al. Effects of topical cyclosporine a plus artificial tears versus artificial tears treatment on conjunctival goblet cell density in dysfunctional tear syndrome. Eye Contact Lens. 2011;37:312-315.
17. Guzey M, Karaman SK, Satici A, et al. Efficacy of topical cyclosporine A in the treatment of severe trachomatous dry eye. Clin Experiment Ophthalmol. 2009;37:541-549.
18. Willen CM, McGwin G, Liu B, et al. Efficacy of cyclosporine 0.05% ophthalmic emulsion in contact lens wearers with dry eyes. Eye Contact Lens. 2008;34:43-45.
19. Chen M, Gong L, Sun X, et al. A comparison of cyclosporine 0.05% ophthalmic emulsion versus vehicle in Chinese patients with moderate to severe dry eye disease: an eight-week, multicenter, randomized, doubleblind, parallel-group trial. J Ocul Pharmacol Ther. 2010;26:361-366.
20. Jain AK, Sukhija J, Dwedi S, et al. Effect of topical cyclosporine on tear functions in tear-deficient dry eyes. Ann Ophthalmol (Skokie). 2007;39: 19-25.
21. Altiparmak UE, Acar DE, Ozer PA, et al. Topical cyclosporine A for the dry eye findings of thyroid orbitopathy patients. Eye (Lond). 2010;24: 1044-1050.
22. Kenneth JR, Timothy LL, Greenland S. Modern Epidemiology. Philadelphia: Lippincott Williams and Wilkins; 2008:652.
23. Lefebvre C, Manheimer E, Glanville J. Designing search strategies. Available at: http://handbook.cochrane.org/. Accessed May 1, 2013.
24. Higgins JP, Sterne JA; ADG, CSMG, Cochrane BMG. Assessing risk of bias in included studies. Available at http://handbook.cochrane.org/. Accessed May 1, 2013.
25. Deeks JJ, Altman DG; HJP, CSMG. Analysing data and undertaking meta-analyses. Available at http://handbook.cochrane.org/. Accessed May 1, 2013.
26. Deeks JJ, Higgins JPT, Altman DG. Identifying and measuring heterogeneity. Available at: http://handbook.cochrane.org/. Accessed May 1, 2013.
27. Deeks JJ, Higgins JPT, Altman DG. Incorporating heterogeneity into random-effects models. Available at: http://handbook.cochrane.org/. Accessed May 1, 2013.
28. Salib GM, McDonald MB, Smolek M. Safety and efficacy of cyclosporine 0.05% drops versus unpreserved artificial tears in dry-eye patients having laser in situ keratomileusis. J Cataract Refract Surg. 2006;32: 772-778.
29. Sall K, Stevenson OD, Mundorf TK, et al. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology. 2000;107:631-639.
30. Baiza-Durán L, Medrano-Palafox J, Hernández-Quintela E, et al. A comparative clinical trial of the efficacy of two different aqueous solutions of cyclosporine for the treatment of moderate-to-severe dry eye syndrome. Br J Ophthalmol. 2010;94:1312-1315.
31. Albietz JM, Bruce AS. The conjunctival epithelium in dry eye subtypes: effect of preserved and non-preserved topical treatments. Curr Eye Res. 2001;22:8-18.