The degree of breath methane production in IBS correlates with the severity of constipation

American Journal of Gastroenterology

Volumn 102, Issue 4, 2007, Pages 837-841

  Chatterjee, Soumya ^a   Park, Sandy ^a   Low, Kimberly ^a   Kong, Yuthana ^a   Pimentel, Mark ^a,b  

^a BURNS AND ALLEN RESEARCH INSTITUTE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHANE;

ADULT; ARTICLE; BREATH ANALYSIS; BREATH METHANE TEST; CONSTIPATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIARRHEA; DISEASE SEVERITY; DOCUMENTATION; FECES; HUMAN; HYDROGEN BREATH TEST; IRRITABLE COLON; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCORING SYSTEM; SYMPTOM; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; BREATH TESTS; CASE-CONTROL STUDIES; CONSTIPATION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IRRITABLE BOWEL SYNDROME; LACTULOSE; MALE; METHANE; MIDDLE AGED;

EID: 33947707344     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2007.01072.x     Document Type: Article

References (28)

1. Manning AP, Thompson WG, Heaton KW, et al. Towards positive diagnosis of the irritable bowel. BMJ 1978;2:653-4.
2. Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 2000;95:3503-6.
3. Pimentel M, Chow EJ, Lin HC. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. A double-blind, randomized, placebo-controlled study. Am J Gastroenterol 2003;98:412-9.
4. Nucera G, Gabriella M, Lupascu A, et al. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2005;21:1391-5.
5. Lupascu A, Gabrielli M, Lauritano EC, et al. Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: A prevalence case-control study in irritable bowel syndrome. Aliment Pharmacol Ther 2005;22:1157-60.
6. McCallum R, Schultz C, Sostarich S. Evaluating the role of small intestinal bacterial overgrowth (SIBO) in diarrhea predominant irritable bowel syndrome (IBS-D) patients utilizing the glucose breath test (GBT). Gastroenterology 2005;128:A460.
7. Simren M, Ringstorm G, Agerforz P, et al. Small intestinal bacterial overgrowth is not of major importance in irritable bowel syndrome. Gastroenterology 2003;124:A163.
8. Robson KM, Kakullavarapu J, Lembo T. Bacterial overgrowth and irritable bowel syndrome: A look at prevalence, symptoms and quality of life. Am J Gastroenterol 2003;98:S271.
9. Posserud I, Stotzer P-O, Bjornsson ES, et al. Altered counts of small bowel bacteria in patients with irritable bowel syndrome. Gastroenterology 2006;130:A739
10. Thompson WG, Longstreth GF, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gut 1999;45(Suppl 2):II43-7.
11. Pimentel M, Mayer AG, Park S, et al. Methane production during lactulose breath test is associated with gastrointestinal disease presentation. Dig Dis Sci 2003;48:86-92.
12. Pimentel M, Lin HC, Enayati P, et al. Methane, a gas produced by enteric bacteria slows intestinal transit and augments small intestinal contractile activity. Am J Physiol 2006;290:G1089-95.
13. Drossman DA, Richter JE, Talley NJ, et al, eds. Functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment: A multinational consensus. Boston: Little, Brown, 1994.
14. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997;32:920-4.
15. Levitt MD, Ingelfinger FJ. Hydrogen and methane production in man. Ann N Y Acad Sci 1968;150:75-81.
16. Levitt MD. Production and excretion of hydrogen gas in man. N Engl J Med 1969;281:122-7.
17. Levitt MD, Bond JH Jr. Volume, composition and source of intestinal gas. Gastroenterology 1970;59:921-9.
18. Bond JH Jr, Engel RR, Levitt MD. Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria. J Exp Med 1971;133:572-88.
19. Calloway DH, Murphy EL. The use of expired air to measure intestinal gas formation. Ann N Y Acad Sci 1968;150:82-95.
20. Pitt P, DeBruijn KM, Beeching MF, et al. Studies on breath methane: The effect of ethnic origins and lactulose. Gut 1980;21:951-9.
21. 4) production in man. Scand J Gastroenterol 1982;17:985-92.
22. Stadtman TC. Methane fermentation. Ann Rev Microbiol 1967;21:121-42.
23. Fiedorek SC, Pumphrey CL, Casteel HB. Breath methane production in children with constipation and encoparesis. J Pediatr Gastroenterol 1990;10:473-7.
24. Weaver GA, Krause JA, Miller TL, et al. Incidence of methanogenic bacteria in a sigmoidoscopy population: An association of methanogenic bacteria and diverticulosis. Gut 1986;27:698-704.
25. Soares AC, Lederman HM, Fagundes-Neto U, et al. Breath methane associated with slow colonic transit time in children with chronic constipation. J Clin Gastroenterol 2005;39:512-5.
26. Cloarec D, Bornet F, Gouilloud S, et al. Breath hydrogen response to lactulose in healthy subjects: Relationship to methane producing status. Gut 1990;31:300-4.
27. Stephen AM, Wiggins HS, Englyst HN, et al. The effect of age, sex and level of intake of dietary fibre from wheat on large-bowel function in thirty healthy subjects. Br J Nutr 1986;56:349-61.
28. Pimentel M, Chatterjee S, Chow EJ, et al. Neomycin improves constipation in IBS in a fashion that is dependent on the presence of methane gas: Sub-analysis of a randomized controlled study. Dig Dis Sci 2006;51:1297-301.