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Volumn 30, Issue 4, 2014, Pages 385-390

Therapy of inflammatory bowel disease: What to expect in the next decade

Author keywords

Emerging therapy; Inflammatory bowel disease; Novel treatments

Indexed keywords

C REACTIVE PROTEIN; CERTOLIZUMAB PEGOL; CHEMOKINE RECEPTOR ANTAGONIST; GOLIMUMAB; HMPL 004; INFLIXIMAB; INTERLEUKIN 12; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 23; INTERLEUKIN 23 ANTIBODY; JANUS KINASE; JANUS KINASE INHIBITOR; LAQUINIMOD; NATALIZUMAB; TOCILIZUMAB; TOFACITINIB; UNCLASSIFIED DRUG; USTEKINUMAB; VEDOLIZUMAB; ANTIINFLAMMATORY AGENT; CCX282-B; MONOCLONAL ANTIBODY; SULFONAMIDE;

EID: 84902264550     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000077     Document Type: Review
Times cited : (17)

References (49)
  • 1
    • 0032913394 scopus 로고    scopus 로고
    • Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
    • D'Haens G, Deventer SV, Hogenzand RV, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial. Gastroenterology 1999; 116:1029-1034.
    • (1999) Gastroenterology , vol.116 , pp. 1029-1034
    • D'haens, G.1    Deventer, S.V.2    Hogenzand, R.V.3
  • 2
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT i randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial. Lancet 2002; 359:1541-1549.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 3
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340:1398-1405.
    • (1999) N Engl J Med , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 4
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn's disease
    • Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004; 350:876-885.
    • (2004) N Engl J Med , vol.350 , pp. 876-885
    • Sands, B.E.1    Anderson, F.H.2    Bernstein, C.N.3
  • 5
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353:2462-2476.
    • (2005) N Engl J Med , vol.353 , pp. 2462-2476
    • Rutgeerts, P.1    Sandborn, W.J.2    Feagan, B.G.3
  • 6
    • 32044451548 scopus 로고    scopus 로고
    • Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
    • Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial. Gastroenterology 2006; 130:323-333.
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 7
    • 34249281002 scopus 로고    scopus 로고
    • Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial
    • Sandborn WJ, Hanauer SB, Rutgeerts P, et al. Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial. Gut 2007; 56:1232-1239.
    • (2007) Gut , vol.56 , pp. 1232-1239
    • Sandborn, W.J.1    Hanauer, S.B.2    Rutgeerts, P.3
  • 8
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial. Gastroenterology 2007; 132:52-65.
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 9
    • 79955859430 scopus 로고    scopus 로고
    • Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: Results of a randomised controlled trial
    • Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: Results of a randomised controlled trial. Gut 2011; 60:780-787.
    • (2011) Gut , vol.60 , pp. 780-787
    • Reinisch, W.1    Sandborn, W.J.2    Hommes, D.W.3
  • 10
    • 84856163835 scopus 로고    scopus 로고
    • Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis
    • Sandborn WJ, van Assche G, Reinisch W, et al. Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 2012; 142:257-265.
    • (2012) Gastroenterology , vol.142 , pp. 257-265
    • Sandborn, W.J.1    Van Assche, G.2    Reinisch, W.3
  • 11
    • 80054743856 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • Schreiber S. Certolizumab pegol for the treatment of Crohn's disease. Therap Adv Gastroenterol 2011; 4:375-389.
    • (2011) Therap Adv Gastroenterol , vol.4 , pp. 375-389
    • Schreiber, S.1
  • 12
    • 84890629055 scopus 로고    scopus 로고
    • Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis
    • Sandborn WJ, Feagan BG, Marano C, et al. Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis. Gastroenterology 2014; 146:96-109.
    • (2014) Gastroenterology , vol.146 , pp. 96-109
    • Sandborn, W.J.1    Feagan, B.G.2    Marano, C.3
  • 13
    • 0037413467 scopus 로고    scopus 로고
    • A controlled trial of natalizumab for relapsing multiple sclerosis
    • Miller DH, Khan OA, Sheremata WA, et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2003; 348:15-23.
    • (2003) N Engl J Med , vol.348 , pp. 15-23
    • Miller, D.H.1    Khan, O.A.2    Sheremata, W.A.3
  • 14
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Colombel JF, Enns R, et al. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 2005; 353: 1912-1925.
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.F.2    Enns, R.3
  • 15
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE trial
    • Targan SR, Feagan BG, Fedorak RN, et al. Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE trial. Gastroenterology 2007; 132:1672-1683.
    • (2007) Gastroenterology , vol.132 , pp. 1672-1683
    • Targan, S.R.1    Feagan, B.G.2    Fedorak, R.N.3
  • 16
    • 84882769357 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for ulcerative colitis
    • Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med 2013; 369:699-710.
    • (2013) N Engl J Med , vol.369 , pp. 699-710
    • Feagan, B.G.1    Rutgeerts, P.2    Sands, B.E.3
  • 17
    • 84882749768 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med 2013; 369:711-721.
    • (2013) N Engl J Med , vol.369 , pp. 711-721
    • Sandborn, W.J.1    Feagan, B.G.2    Rutgeerts, P.3
  • 18
    • 84902288793 scopus 로고    scopus 로고
    • Food and Drug Administration. FDA approves Entyvio to treat ulcerative colitis and Crohn's disease. 2013
    • Food and Drug Administration. FDA approves Entyvio to treat ulcerative colitis and Crohn's disease. 2013.
  • 19
    • 79955562875 scopus 로고    scopus 로고
    • Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Takazoe M, Watanabe M, Kawaguchi T, et al. Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: A randomized, double-blind, placebo-controlled trial. Gastroenterology 2009; 136:A181.
    • (2009) Gastroenterology , vol.136
    • Takazoe, M.1    Watanabe, M.2    Kawaguchi, T.3
  • 20
    • 84902244429 scopus 로고    scopus 로고
    • Ajinomoto Pharmaceuticals. PIIa Clinical Study Results of AJM300 in Ulcerative Colitis: Oral a4 integrin inhibitor was demonstrated to be effective in treatment of inflammatory bowel disease for the first time in the world [Accessed 2 February 2014]
    • Ajinomoto Pharmaceuticals. PIIa Clinical Study Results of AJM300 in Ulcerative Colitis: Oral a4 integrin inhibitor was demonstrated to be effective in treatment of inflammatory bowel disease for the first time in the world. http:// www.ajinomoto-seiyaku.co.jp/newsrelease/2013/1106e.pdf. [Accessed 2 February 2014]
  • 21
    • 84894535990 scopus 로고    scopus 로고
    • Differentiation between etrolizumab (rhuMAb beta7) and placebo in the Eucalyptus phase II randomized double-blind placebo-controlled induction study to evaluate efficacy and safety in patients with refractory moderate-to-severely active ulcerative colitis
    • Vermeire S, O'Byrne S, Williams M, Mansfield J. Differentiation between etrolizumab (rhuMAb beta7) and placebo in the Eucalyptus phase II randomized double-blind placebo-controlled induction study to evaluate efficacy and safety in patients with refractory moderate-to-severely active ulcerative colitis. Gastroenterology 2013; 144:S-36.
    • (2013) Gastroenterology , vol.144
    • Vermeire, S.1    O'byrne, S.2    Williams, M.3    Mansfield, J.4
  • 22
    • 79960336916 scopus 로고    scopus 로고
    • The mucosal addressin cell adhesion molecule antibody PF-00547659 in ulcerative colitis: A randomised study
    • Vermeire S, Ghosh S, Panes J, et al. The mucosal addressin cell adhesion molecule antibody PF-00547659 in ulcerative colitis: A randomised study. Gut 2011; 60:1068-1075.
    • (2011) Gut , vol.60 , pp. 1068-1075
    • Vermeire, S.1    Ghosh, S.2    Panes, J.3
  • 23
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 2008; 135:1130-1141.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 24
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 2012; 367: 1519-1528.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 25
    • 84902278245 scopus 로고    scopus 로고
    • ClinicalTrials.gov: National Institutes of Health, 2014. http://clinicaltrials.gov/ ct2/show/NCT01369342 and . [Accessed 29 January 2014]
    • ClinicalTrials.gov: National Institutes of Health, 2014. http://clinicaltrials.gov/ ct2/show/NCT01369342 and http://clinicaltrials.gov/ ct2/show/NCT 01369355. [Accessed 29 January 2014]
  • 26
    • 84865013186 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
    • Sandborn WJ, Ghosh S, Panes J, et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 2012; 367:616-624.
    • (2012) N Engl J Med , vol.367 , pp. 616-624
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3
  • 27
    • 77957244016 scopus 로고    scopus 로고
    • Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease
    • Walters MJ, Wang Y, Lai N, et al. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease. J Pharmacol Exp Ther 2010; 335:61-69.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 61-69
    • Walters, M.J.1    Wang, Y.2    Lai, N.3
  • 28
    • 0034899072 scopus 로고    scopus 로고
    • CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease
    • Papadakis KA, Prehn J, Moreno ST, et al. CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Gastroenterology 2001; 121:246-254.
    • (2001) Gastroenterology , vol.121 , pp. 246-254
    • Papadakis, K.A.1    Prehn, J.2    Moreno, S.T.3
  • 29
    • 84875195096 scopus 로고    scopus 로고
    • A randomized controlled trial of the efficacy and safety of CCX282-B, an orally-administered blocker of chemokine receptor CCR9, for patients with Crohn's disease
    • Keshav S, Vanasek T, Niv Y, et al. A randomized controlled trial of the efficacy and safety of CCX282-B, an orally-administered blocker of chemokine receptor CCR9, for patients with Crohn's disease. PloS One 2013; 8: e60094.
    • (2013) PloS One , vol.8
    • Keshav, S.1    Vanasek, T.2    Niv, Y.3
  • 30
    • 84885629929 scopus 로고    scopus 로고
    • New therapeutic avenues in ulcerative colitis: Thinking out of the box
    • Torres J, Danese S, Colombel JF. New therapeutic avenues in ulcerative colitis: thinking out of the box. Gut 2013; 62:1642-1652.
    • (2013) Gut , vol.62 , pp. 1642-1652
    • Torres, J.1    Danese, S.2    Colombel, J.F.3
  • 31
    • 84893725774 scopus 로고    scopus 로고
    • Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: A phase II randomised study
    • Mayer L, Sandborn WJ, Stepanov Y, et al. Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: A phase II randomised study. Gut 2014; 63:442-450.
    • (2014) Gut , vol.63 , pp. 442-450
    • Mayer, L.1    Sandborn, W.J.2    Stepanov, Y.3
  • 32
    • 84891738394 scopus 로고    scopus 로고
    • Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases
    • Antonelli A, Ferrari SM, Giuggioli D, et al. Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases. Autoimmun Rev 2014; 13:272-280.
    • (2014) Autoimmun Rev , vol.13 , pp. 272-280
    • Antonelli, A.1    Ferrari, S.M.2    Giuggioli, D.3
  • 33
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology 2009; 136:1182-1197.
    • (2009) Gastroenterology , vol.136 , pp. 1182-1197
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3
  • 34
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human antiinterleukin-6 receptor monoclonal antibody in active Crohn's disease
    • Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human antiinterleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126:989-996.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 35
    • 84862783578 scopus 로고    scopus 로고
    • A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate
    • Mease P, Strand V, Shalamberidze L, et al. A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate. Ann Rheum Dis 2012; 71:1183-1189.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1183-1189
    • Mease, P.1    Strand, V.2    Shalamberidze, L.3
  • 36
    • 84862865685 scopus 로고    scopus 로고
    • Drug delivery trends in clinical trials and translational medicine: Growth in biologic molecule development and impact on rheumatoid arthritis, Crohn's disease, and colitis
    • Ho RJ, Chien JY. Drug delivery trends in clinical trials and translational medicine: growth in biologic molecule development and impact on rheumatoid arthritis, Crohn's disease, and colitis. J Pharm Sci 2012; 101:2668-2674.
    • (2012) J Pharm Sci , vol.101 , pp. 2668-2674
    • Ho, R.J.1    Chien, J.Y.2
  • 37
    • 67650463349 scopus 로고    scopus 로고
    • Oral laquinimod therapy in relapsing multiple sclerosis
    • Preiningerova J. Oral laquinimod therapy in relapsing multiple sclerosis. Expert Opin Investig Drugs 2009; 18:985-989.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 985-989
    • Preiningerova, J.1
  • 38
    • 84886293617 scopus 로고    scopus 로고
    • 90 safety and efficacy of laquinimod in inducing clinical and biochemical improvement in active Crohn's disease: Results of an exploratory trial
    • D'Haens GR, Colombel J-F, Sandborn W, et al. 90 safety and efficacy of laquinimod in inducing clinical and biochemical improvement in active Crohn's disease: Results of an exploratory trial. Gastroenterology 2013; 144:S-21.
    • (2013) Gastroenterology , vol.144
    • D'haens, G.R.1    Colombel, J.-F.2    Sandborn, W.3
  • 39
    • 84873646726 scopus 로고    scopus 로고
    • HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses
    • Michelsen KS, Wong MH, Ko B, et al. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses. Inflamm Bowel Dis 2013; 19:151-164.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 151-164
    • Michelsen, K.S.1    Wong, M.H.2    Ko, B.3
  • 40
    • 84872012274 scopus 로고    scopus 로고
    • Andrographis paniculata extract (HMPL-004) for active ulcerative colitis
    • Sandborn WJ, Targan SR, Byers VS, et al. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol 2013; 108:90-98.
    • (2013) Am J Gastroenterol , vol.108 , pp. 90-98
    • Sandborn, W.J.1    Targan, S.R.2    Byers, V.S.3
  • 42
    • 0031889085 scopus 로고    scopus 로고
    • Course of Crohn's disease after allogeneic marrow transplantation
    • Lopez-Cubero SO, Sullivan KM, McDonald GB. Course of Crohn's disease after allogeneic marrow transplantation. Gastroenterology 1998; 114:433-440.
    • (1998) Gastroenterology , vol.114 , pp. 433-440
    • Lopez-Cubero, S.O.1    Sullivan, K.M.2    McDonald, G.B.3
  • 43
    • 84879990805 scopus 로고    scopus 로고
    • P362 autologous haematopoietic stem cell transplantation without CD34þ cell selection for refractory Crohn's disease: The Milan experience after 5 years
    • Cassinotti A, Onida F, Annaloro C, et al. P362 autologous haematopoietic stem cell transplantation without CD34þ cell selection for refractory Crohn's disease: The Milan experience after 5 years. J Crohn's Colitis 2012; 6:S153-S154.
    • (2012) J Crohn's Colitis , vol.6
    • Cassinotti, A.1    Onida, F.2    Annaloro, C.3
  • 44
    • 78650653452 scopus 로고    scopus 로고
    • Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: Long-term follow-up
    • Burt RK, Craig RM, Milanetti F, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up. Blood 2010; 116:6123-6132.
    • (2010) Blood , vol.116 , pp. 6123-6132
    • Burt, R.K.1    Craig, R.M.2    Milanetti, F.3
  • 45
    • 84924251016 scopus 로고    scopus 로고
    • OC-014 clinical and endoscopic improvement following hematopoietic stem cell transplantation vs mobilisation alone in Crohn's disease
    • Hawkey C, Allez M, Ardizzone S, et al. OC-014 clinical and endoscopic improvement following hematopoietic stem cell transplantation vs mobilisation alone in Crohn's disease. Gut 2013; 62 (Suppl 1):A6.
    • (2013) Gut , vol.62 , Issue.SUPPL. 1.
    • Hawkey, C.1    Allez, M.2    Ardizzone, S.3
  • 46
    • 64049104052 scopus 로고    scopus 로고
    • Expanded adipose-derived stem cells for the treatment of complex perianal fistula: A phase II clinical trial
    • Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: A phase II clinical trial. Dis Colon Rectum 2009; 52:79-86.
    • (2009) Dis Colon Rectum , vol.52 , pp. 79-86
    • Garcia-Olmo, D.1    Herreros, D.2    Pascual, I.3
  • 47
    • 21644462655 scopus 로고    scopus 로고
    • A phase i clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation
    • García-Olmo D, García-Arranz M, Herreros D, et al. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005; 48:1416-1423.
    • (2005) Dis Colon Rectum , vol.48 , pp. 1416-1423
    • García-Olmo, D.1    García-Arranz, M.2    Herreros, D.3
  • 48
    • 79955853222 scopus 로고    scopus 로고
    • Autologous bone marrowderived mesenchymal stromal cells in the treatment of fistulising Crohn's disease
    • Ciccocioppo R, Bernardo ME, Sgarella A, et al. Autologous bone marrowderived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 2011; 60:788-798.
    • (2011) Gut , vol.60 , pp. 788-798
    • Ciccocioppo, R.1    Bernardo, M.E.2    Sgarella, A.3
  • 49
    • 84890190232 scopus 로고    scopus 로고
    • A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy
    • Forbes GM, Sturm MJ, Leong RW, et al. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy. Clin Gastroenterol Hepatol 2014; 12:64-71.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 64-71
    • Forbes, G.M.1    Sturm, M.J.2    Leong, R.W.3


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