Is oxygen required before atropine administration in organophosphorus or carbamate pesticide poisoning?-A cohort study

Clinical Toxicology

Volumn 52, Issue 5, 2014, Pages 531-537

  Konickx, L A ^a,b   Bingham, K ^a   Eddleston, M ^a,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

Atropine; Carbamate; Organophosphorus; Oxygen; Ventricular dysrhythmia

Indexed keywords

ATROPINE; CARBAMATE PESTICIDE; ORGANOPHOSPHORUS COMPOUND; OXYGEN; PRALIDOXIME CHLORIDE;

ADULT; ARTICLE; COHORT ANALYSIS; FEMALE; HEART ARREST; HEART DEATH; HUMAN; INTOXICATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OXYGEN THERAPY; PATIENT CARE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESUSCITATION; SRI LANKA;

ATROPINE; CARBAMATE; ORGANOPHOSPHORUS; OXYGEN; VENTRICULAR DYSRHYTHMIA;

ADULT; ANTIDOTES; ATROPINE; CARBAMATES; CHOLINESTERASE INHIBITORS; COHORT STUDIES; FEMALE; HEART ARREST; HUMANS; INCIDENCE; MALE; MIDDLE AGED; ORGANOPHOSPHATE POISONING; OXYGEN; PESTICIDES; PROSPECTIVE STUDIES; RESUSCITATION; SRI LANKA; TIME FACTORS;

EID: 84902246601     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2014.915411     Document Type: Article

References (64)

1. Jeyaratnam J. Acute pesticide poisoning: a major global health problem. Wld Hlth Statist Quart 1990;43:139-144.
2. Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. Q J Med 2000;93:715-731.
3. Gunnell D, Eddleston M, Phillips MR, Konradsen F. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health 2007;7:357.
4. Bertolote JM, Fleischmann A, Eddleston M, Gunnell D. Deaths from pesticide poisoning: a global response. Brit J Psychiat 2006;189:201-203.
5. Bertolote JM, Fleischmann A, Butchart A, Besbelli N. Suicide, suicide attempts and pesticides: a major hidden public health problem. Bull World Health Organ 2006; 84: 260.
6. Ballantyne B, Marrs TC. Overview of the biological and clinical aspects of organophosphates and carbamates. In: Ballantyne B, Marrs TC, eds. Clinical and experimental toxicology of organophosphates and carbamates. Oxford: Butterworth heinemann; 1992:3-14.
7. Lotti M. Clinical toxicology of anticholinesterase agents in humans. In: Krieger RI, Doull J, eds. Handbook of Pesticide Toxicology, Vol 2. Agents, 2 edn. San Diego: Academic Press, 2001:1043-1085.
8. Eddleston M, Buckley NA, Checketts H, Senarathna L, Mohamed F, Sheriff MH, Dawson A. Speed of initial atropinisation in significant organophosphorus pesticide poisoning-a systematic comparison of recommended regimens. J Toxicol Clin Toxicol 2004;42:865-875.
9. Eddleston M, Szinicz L, Eyer P, Buckley N. Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. Q J Med 2002;95:275-283.
10. Namba T, Nolte C, Jackrel J, Grob D. Poisoning due to organophosphate insecticides. Am J Med 1971;50:475-492.
11. Eddleston M, Buckley NA, Eyer P, Dawson AH. Medical management of acute organophosphorus pesticide poisoning. Lancet 2008;371:597-607.
12. Abedin MJ, Sayeed AA, Basher A, Maude RJ, Hoque G, Faiz MA. Open-label randomized clinical trial of atropine bolus injection versus incremental boluses plus infusion for organophosphate poisoning in Bangladesh. J Med Toxicol 2012;8:108-117.
13. Eddleston M, Dawson A, Karalliedde L, Dissanayake W, Hittarage A, Azher S, Buckley NA. Early management after self-poisoning with an organophosphorus or carbamate pesticide-a treatment protocol for junior doctors. Crit Care 2004;8:R391-R397.
14. Eddleston M, Sheriff MH, Hawton K. Deliberate self-harm in Sri Lanka: an overlooked tragedy in the developing world. BMJ 1998;317:133-135.
15. Aggarwal P, Wali J P. Diagnosis and Management of Common Poisoning. Delhi: Oxford University Press;1997.
16. Balali-Mood M, Balali-Mood K, Moodi M, Balali-Mood B. Health aspects of organophosphorous pesticides in asian countries. Iran J Public Health 2012;41:1-14.
17. Baskin SI. Principles of Cardiac Toxicology. Boca Raton, Florida: CRC Press;1991.
18. DURHAM WF, Hayes WJ Jr. Organic phosphorus poisoning and its therapy. With special reference to modes of action and compounds that reactivate inhibited cholinesterase. Arch Environ Health 1962;5:21-47.
19. Flanagan R J, Jones A L. Antidotes. Principles and Applications. London: Taylor & Francis;2001.
20. Haddad LM, Shannon MW, Winchester JF. Clinical management of poisoning and drug overdose. 2nd ed. Philadelphia: W B Saunders;1983.
21. Hayes WJ Jr. Clinical Handbook of Economic Poisons. Washington, DC: U. S. Government Printing Office;1963.
22. Hayes WJ Jr. Parathion poisoning and its treatment. JAMA 1965;192:49-50.
23. Heath AJ, Meredith T. Atropine in the management of anticholinesterase poisoning. In: Ballantyne B, Marrs T, eds. Clinical and Experimental Toxicology of Organophosphates and Carbamates. Oxford: Butterworth Heinemann; 1992:543-554.
24. Holmstedt B. Pharmacology of organophosphorus cholinesterase inhibitors. Pharmacol Rev 1959;11:567-688.
25. Joshi S, Biswas B, Malla G. Management of organophosphorus poisoning. Update Anaesth 2009;9:31-35.
26. Kecik Y, Yorukoglu D, Saygin B, Sekerci S. A case of acute poisoning due to organophosphate insecticide. Anaesthesia 1993; 48: 141-143.
27. Matthew H, Lawson AAH. Treatment of Acute Poisonings. 2nd ed. Edinburgh: Churchill Livingstone;1975.
28. Milby TH. Prevention and management of organophosphate poisoning. JAMA 1971;216:2131-2133.
29. Matthew H. Acute poisoning. Community Health 1970;2:18-22.
30. Polson CJ, Green MA, Lee MR. Clinical Toxicology. London: Pitman;1983.
31. Singh S, Sharma N. Neurological syndromes following organophosphate poisoning. Neurol India 2000;48:308.
32. Finkelstein Y, Kushnir A, Raikhlin-Eisenkraft B, Taitelman U. Antidotal therapy of severe acute organophosphate poisoning: a multihospital study. Neurotoxicol Teratol 1989;11:593-596.
33. Fernandez MC. Atropine. In: Dart RC, ed. Medical Toxicology. 3rd edn. Philadelphia: Lippincott, Williams & Wilkins, 2004:163-164.
34. Erdman AR. Insecticides. In: Dart RC, ed. Medical Toxicology. 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 2004:1475-1496.
35. Fernando R. Preventable acute organophosphate poisoning deaths. Ceylon Med J 1989;34:139-142.
36. Gosselin RE, Smith RP, Hodge HC, Braddock JE. Clinical Toxicology of Commercial Products. 5th ed. Baltimore, MD: Williams & Wilkins;1984.
37. Ludomirsky A, Klein HO, Sarelli P, Becker B, Hoffman S, Taitelman U, et al. Q-T prolongation and polymorphous (" torsade de pointes " ) ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am J Cardiol 1982;49:1654-1658.
38. Morgan D P. Recognition and Management of Pesticide Poisoning. 3rd ed. Washington, DC: EPA;1982.
39. Reigart J R, Roberts J R. Organophosphate insecticides. In: Recognition and Management of Pesticide Poisonings. 5th edn. Washington, DC: Office of Pesticide Programs, U.S. Environmental Protection Agency;1999:34-47.
40. Tafuri J, Roberts J. Organophosphate Poisoning. Ann Emerg Med 1987;16:193-202.
41. Hase NK, Shrinivasan J, Divekar MV, Gore AG. Atropine induced ventricular fibrillation in a case of diazinon poisoning. J Assoc Physicians India 1984; 32: 536.
42. Eddleston M, Eyer P, Worek F, Mohamed F, Senarathna L, von Meyer L, et al. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 2005;366:1452-1459.
43. Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W, et al. Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. Lancet 2008;371:579-586.
44. Eddleston M, Eyer P, Worek F, Juszczak E, Alder N, Mohamed F, et al. Pralidoxime in acute organophosphorus insecticide poisoning-a randomised controlled trial. PLoS Med 2009;6:e1000104.
45. Davies JOJ, Roberts DM, Eyer P, Buckley NA, Eddleston M. Hypotension in severe dimethoate self-poisoning. Clin Toxicol 2008;46:880-884.
46. Saadeh AM, Farsakh NA, Alali MK. Cardiac manifestations of acute carbamate and organophosphate poisoning. Heart 1997; 77: 461-464.
47. Karki P, Ansari JA, Bhandary S, Koirala S. Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. Singapore Med J 2004; 45: 385-389.
48. Roberts DM, Aaron CK. Management of acute organophosphorus pesticide poisoning. BMJ 2007;334:629-634.
49. Sundaray N K, Kumar R. Organophosphorus poisoning: current management guidelines. In: Rao MS, ed. Medicine Update. 20th ed. New Delhi: Association of Physicians of India; 2010: 420-425.
50. Cooper MJ, Abinader EG. Atropine-induced ventricular fibrillation: case report and review of the literature. Am Heart J 1979;97:225-228.
51. Kent KM, Smith ER, Redwood DR, Epstein SE. Electrical stability of acutely ischemic myocardium. Influences of heart rate and vagal stimulation. Circulation 1973;47:291-298.
52. Webb SW, Adgey AA, Pantridge JF. Autonomic disturbance at onset of acute myocardial infarction. Br Med J 1972;3:89-92.
53. Goel V K, Mehrotra T N, Gupta S K. Ventricular tachyarrhythmia: complication of atropine therapy in acute myocardial infarction. Indian Heart J 1981;33:301-302.
54. Wills JH, McNamara BP, Fine EA. Ventricular fibrillation in delayed treatment of TEPP poisoning. Fed Proc 1950;9:136 (Ref Type: Abstract).
55. Freeman G, Ludemann H, Cornblath M, Gold A, Filbert M, Udall J, et al. Cardiovascular and respiratory effect of acute parathion poisoning in dogs with particular regard to ventricular fibrillation. Army Chemical Centre, MD; 1954. Report No.: 303.
56. Eddleston M, Street JM, Self I, Thompson A, King T, Williams N, et al. A role for solvents in the toxicity of agricultural organophosphorus pesticides. Toxicology 2012;294:94-103.
57. KROP S, Kunkel AM. Observations on pharmacology of the anticholinesterases sarin and tabun. Proc Soc Exp Biol Med 1954;86:530-533.
58. Kunkel AM, O'Leary JF, Jones AH. Atropine-induced ventricular fibrillation during cyanosis caused by organophosphorus poisoning. Edgewood Arsenal Technical Report 4711 1973.
59. Ludemann H, Cornblath M, Gold A, Filbert M, Udall J, Harkabus R, et al. Ventricular fibrillation following atropine in acute sarin poisoning in dogs. Army Chemical Center, MD; 1955. Report No.: 402.
60. Hayes WJ. Pesticides Studied in Man. Baltimore, MD: Williams & Wilkins;1982.
61. Morgan D P. Recognition and Management of Pesticide Poisonings. Atlanta GA: US EPA Office of Pesticide Programs;1989.
62. Massumi RA, Mason DT, Amsterdam EA, DeMaria A, Miller RR, Scheinman MM, et al. Ventricular fibrillation and tachycardia after intravenous atropine for treatment of bradycardias. N Engl J Med 1972;287:336-338.
63. Teitelman U, Adler M, Levy I. Treatment of massive poisoning by the organophosphate pesticide methidathion. Clin Toxicol 1975; 8: 277-282.
64. Wood JR. Medical problems in chemical warfare. Can Med Assoc J 1951;64:35-39.