Open-Label Randomized Clinical Trial of Atropine Bolus Injection Versus Incremental Boluses Plus Infusion for Organophosphate Poisoning in Bangladesh

Journal of Medical Toxicology

Volumn 8, Issue 2, 2012, Pages 108-117

  Abedin, Mohammed Joynal ^a   Sayeed, Abdullah Abu ^a   Basher, Ariful ^b   Maude, Richard J ^c,d   Hoque, Gofranul ^a   Faiz, M A ^b  

^a CHITTAGONG MEDICAL COLLEGE   (Bangladesh)

^b DHAKA MEDICAL COLLEGE   (Bangladesh)

^c MAHIDOL OXFORD TROPICAL MEDICINE RESEARCH UNIT   (Thailand)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Atropine; Organophosphate compound (OPC); Poisoning

Indexed keywords

ATROPINE; ORGANOPHOSPHATE; PRALIDOXIME;

ADULT; ARTICLE; BANGLADESH; CAUSE OF DEATH; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INTOXICATION; ISCHEMIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; ORGANOPHOSPHATE POISONING; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY ARREST; RESPIRATORY FAILURE; SHOCK; SURVIVAL RATE; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; AGED; ATROPINE; BANGLADESH; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; ORGANOPHOSPHORUS COMPOUNDS;

EID: 84862490909     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-012-0214-6     Document Type: Article

References (33)

1. Faiz MA, Rahman MR, Ahmed T (1994) Management of acute poisoning with organophosphorus insecticide. J Bang Coll Phys Surg 12: 59-62.
2. Eddleston M (2000) Patterns and problems of deliberate self-poisoning in the developing world. Q J Med 93: 715-731.
3. Eddleston M, Phillips MR (2004) Self poisoning with pesticides. BMJ 328: 42-44.
4. Buckley NA, Karalliedde L, Dawson A, Senanayake N, Eddleston M (2004) Where is the evidence for the management of pesticide poisoning-is clinical toxicology fiddling while the developing world burns? J Toxicol Clin Toxicol 42: 113-116.
5. Buckley NA, Eddleston M, Li Y, Bevan M, Robertson J. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst Rev 2011; CD005085.
6. Blain PG. Organophosphorus poisoning (acute). Clin Evid (Online). 2011; 2011: 2102.
7. Eddleston M, Buckley NA, Eyer P, Dawson AH (2008) Management of acute organophosphorus pesticide poisoning. Lancet 371: 597-607.
8. Eddleston M, Singh S, Buckley N (2003) Acute organophosphorus poisoning. Clinical Evidence 10: 1652-1663.
9. Eddleston M, Szinicz L, Eyer P, Buckley N (2002) Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. Q J Med 95: 275-283.
10. Eddleston M, Dawson A, Karalliedde L, Dissanayake W, Hittarage A et al (2004) Early management after self poisoning with an organophosphorus or carbamate pesticide-a treatment protocol for junior doctors. Crit Care 8: 391-396.
11. Lotti M (1991) Treatment of acute organophosphorus poisoning. Med J Aug 154: 51-55.
12. Minton NA, Murray VS (1988) A review of organophosphorus poisoning. Med Toxicol 3: 350-357.
13. Eddleston M, Buckley NA, Dawson AH et al (2004) Speed of initial atropinisation in significant organophosphorus pesticide poisoning-a systematic comparison of recommended regimens. J Toxicol Clin Toxicol 42: 865-875.
14. Sunder Ram J, Kumar SS, Jayarajan A, Kuppuswamy G (1991) Continuous infusion of high doses of atropine in the management of organophosphorus compound poisoning. J Asso Phys India 39: 190-193.
15. Karalliedde L, Senanayake N (1988) Pattern of acute poisoning in a medical unit in central Sri Lanka. Forensic Sci Int 36: 101-104.
16. Jeyaratnam J, de Alwis Seneviratne RS, Copplestone JF (1982) Survey of pesticide poisoning in Sri Lanka. Bull WHO 60: 615-619.
17. Wyckoff DW, Davies JE, Barquet A, Davis JH (1968) Diagnostic and therapeutic problems of parathion poisonings. Ann Int Med 68: 875-882.
18. Yamashita M, Tanaka J, Ando Y (1997) Human Mortality in organophosphate poisonings. Vet Hum Toxicol 39: 84-85.
19. Abdollahi M, Jalali N, Sabzevari O, Hoseini R, Ghanea T (1997) A retrospective study of poisoning in Tehran. J Clin Toxicol 35: 387-393.
20. Davies JO, Eddleston M, Buckley NA (2008) Predicting outcome in acute organophosphorus poisoning with a poison severity score or the Glasgow coma scale. QJM 101: 371-9.
21. Bird SB, Gaspari RJ, Dickson EW (2003) Early death due to severe organophosphate poisoning is a centrally mediated process. Acad Emerg Med 10: 295-298.
22. Dickson EW, Bird S, Gaspari RJ, Boyer EW, Ferris DF (2003) Diazepam inhibits organophosphate-induced central respiratory depression. Acad Emerg Med 10: 1303-1306.
23. Basu A, Das AK, Chandrasekar S (1988) Organophosphorus poisoning-a clinical profile. J Asso Phys India 36: 24.
24. Ballantyne B, Marrs TC (1992) Overview of the biological and clinical aspects of organophosphates and carbamates. In: Clinical and experimental toxicology of organophosphates and carbamates. Butterworth Heinemann, Oxford, pp 3-14.
25. de Alwis LBL, Salgado MSL (1988) Agrochemical poisoning in Sri Lanka. Forensic Sci Int 36: 81-89.
26. Alam MS (1995) Agrochemicals and its medicolegal hazards a retrospective study at Sher-E-Bangla Medical College, Barisal from 1990-1992. J Teachers Asso SBMC & H, Bang 6: 367-369.
27. Faiz MA (2004) An urgent need for improvement of management of poisoning (editorial). J Dhaka Med Coll 13: 1-3.
28. Jayawardane P, Dawson AH, Weerasinghe V, Karalliedde L, Buckley NA, Senanayake N (2008) The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka. PLoS Med 5: e147.
29. Bardin PG, van Eeden SF, Joubert JR (1987) Intensive care management of acute organophosphate poisoning: a 7-year experience in the Western Cape. S Afr Med J 72: 593-597.
30. Rajapakse VP, Wijesekera S (1989) Outcome of mechanical ventilation in Sri Lanka. Ann R Coll Surg Engl 71: 344-346.
31. Yen DH, Yien HW, Wang LM, Lee CH, Chan SH (2000) Spectral analysis of systemic arterial pressure and heart rate signals of patients with acute respiratory failure induced by severe organophosphate poisoning. Crit Care Med 28: 2805-2811.
32. World Health Organization. International programme on chemical safety evaluation. Antidotes for poisoning by organophosphorus pesticides. Monograph on Atropine. 2002. (Accessed at http://www. inchem. org/documents/antidote/antidote/atropine. htm on 17th October 2011).
33. Perera PM, Shahmy S, Gawarammana I, Dawson AH (2008) Comparison of two commonly practiced atropinization regimens in acute organophosphorus and carbamate poisoning, doubling doses vs. ad hoc: a prospective observational study. Hum Exp Toxicol 27: 513-8.