Over one-third of African-American MGUS and multiple myeloma patients are carriers of hyperphosphorylated paratarg-7, an autosomal dominantly inherited risk factor for MGUS/MM

International Journal of Cancer

Volumn 135, Issue 4, 2014, Pages 934-938

  Zwick, Carsten ^a   Held, Gerhard ^a   Auth, Michaela ^a   Bernal Mizrachi, Leon ^b   Roback, John D ^b   Sunay, Susan ^b   Iida, Shinsuke ^c   Kuroda, Yoshiaki ^d   Sakai, Akira ^e   Ziepert, Marita ^f   Ueda, Ryuzo ^g   Pfreundschuh, Michael ^a   Preuss, Klaus Dieter ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^e FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^f UNIVERSITY OF LEIPZIG   (Germany)

^g AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

genetics; MGUS; multiple myeloma; risk factors

Indexed keywords

PARAPROTEIN; PARATARG 7 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CONTROLLED STUDY; ETHNICITY; EUROPE; GENE MUTATION; HUMAN; INCIDENCE; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETICS; MGUS; MULTIPLE MYELOMA; RISK FACTORS;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; EUROPE; GENES, DOMINANT; HETEROZYGOTE; HUMANS; ISOELECTRIC FOCUSING; JAPAN; MIDDLE AGED; MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE; MULTIPLE MYELOMA; MUTATION; ODDS RATIO; PARAPROTEINS; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; PROTEIN PHOSPHATASE 2; RISK FACTORS; UNITED STATES;

EID: 84902243014     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28731     Document Type: Article

References (11)

1. Greenberg AJ, Rajkumar SV, Vachon CM,. Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, #risk |factors, and biological characteristics. Blood 2012; 119: 5359-66.
2. Sahin U, Tureci O, Schmitt H, et al. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 1995; 92: 11810-3.
3. Preuss KD, Pfreundschuh M, Ahlgrimm M, et al. A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS. Int J Cancer 2009; 125: 656-61.
4. Grass S, Preuss K-D, Ahlgrimm A, et al. Association of a dominantly inherited hyperphosphorylated paraprotein target with sporadic and familial multiple myeloma and monoclonal gammopathy of undetermined significance: a case-control study. Lancet Oncol 2009; 10: 950-6.
5. Grass S, Preuss KD, Wikowicz A, et al. Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenstrom macroglobulinemia. Blood 2011; 117: 2918-23.
6. Preuss KD, Pfreundschuh M, Fadle N, et al. Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A. Blood 2011; 118: 3340-6.
7. Wang Y, Morrow JS,. Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues. J Biol Chem 2000; 275: 8062-71.
8. Cui Z, Zhang L, Hua Z, et al. Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma. Oncol Rep 2007; 17: 829-33.
9. Iwanaga M, Tagawa M, Tsukasaki K, et al. Prevalence of monoclonal gammopathy of undetermined significance: study of 52,802 persons in Nagasaki City, Japan. Mayo Clin Proc 2007; 82: 1474-9.
10. Landgren O, Weiss BM,. Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis. Leukemia 2009; 23: 1691-7.
11. Grass S, Preuss KD, Thome S, et al. Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM. Blood 2011; 118: 635-7.