Supporting small steps toward big innovations: The importance of rigorous pilot studies in critical care

Journal of Critical Care

Volumn 29, Issue 4, 2014, Pages 669-670

  Turnbull, Alison E ^a   Parker, Ann M ^a   Needham, Dale M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL VENTILATION; CLINICAL EFFECTIVENESS; DEEP SEDATION; DELIRIUM; DISEASE SEVERITY; EDITORIAL; FEASIBILITY STUDY; FUNCTIONAL ELECTRICAL STIMULATION; HEALTH CARE QUALITY; INTENSIVE CARE; INTENSIVE CARE UNIT; NURSE; OUTCOME ASSESSMENT; PATIENT SAFETY; PHYSIOTHERAPIST; PHYSIOTHERAPY; PILOT STUDY; PROFESSIONAL COMPETENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REHABILITATION; SAMPLE SIZE; SEDATION; CRITICAL ILLNESS; ELECTROSTIMULATION THERAPY; FEMALE; HUMAN; MALE; PROCEDURES;

CRITICAL ILLNESS; ELECTRIC STIMULATION THERAPY; FEMALE; HUMANS; MALE;

EID: 84902188999     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2014.04.006     Document Type: Editorial

References (16)

1. Sricharoenchai T., Parker A.M., Zanni J.M., Nelliot A., Dinglas V.D., Needham D.M. Safety of physical therapy interventions in critically ill patients: a single-center prospective evaluation of 1110 intensive care unit admissions. J Crit Care 2014, 29:395-400.
2. Adler J., Malone D. Early mobilization in the intensive care unit: a systematic review. Cardiopulm Phys Ther J 2012, 23:5-13.
3. Kayambu G., Boots R., Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis. Crit Care Med 2013, 41:1543-1554.
4. Thomsen G.E., Snow G.L., Rodriguez L., Hopkins R.O. Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med 2008, 36:1119-1124.
5. Leditschke I.A., Green M., Irvine J., Bissett B., Mitchell I.A. What are the barriers to mobilizing intensive care patients?. Cardiopulm Phys Ther J 2012, 23:26-29.
6. Mendez-Tellez P.A., Dinglas V.D., Colantuoni E., Ciesla N., Sevransky J.E., Shanholtz C., et al. Factors associated with timing of initiation of physical therapy in patients with acute lung injury. J Crit Care 2013, 28:980-984.
7. Camargo Pires-Neto R., Fogaça Kawaguchi Y.M., Sayuri Hirota A., Fu C., Tanaka C., Caruso P., et al. Very early passive cycling exercise in mechanically ventilated critically ill patients: physiological and safety aspects-a case series. PLoS ONE 2013, 8:e74182.
8. Parry S.M., Berney S., Warrillow S., El-Ansary D., Bryant A., Hart N., et al. Functional electric stimulation with cycling in the critically ill: a pilot case-matched control study. J Crit Care 2014 Aug, 20(4):695.e1-695.e7. 10.1016/j.jcrc.2014.03.017.
9. Decker M.J., Griffin L., Abraham L.D., Brandt L. Alternating stimulation of synergistic muscles during functional electrical stimulation cycling improves endurance in persons with spinal cord injury. J Electromyogr Kinesiol 2010, 20:1163-1169.
10. Ambrosini E., Ferrante S., Pedrocchi A., Ferrigno G., Molteni F. Cycling induced by electrical stimulation improves motor recovery in postacute hemiparetic patients: a randomized controlled trial. Stroke J Cereb Circ 2011, 42:1068-1073.
11. Arnold D.M., Burns K.E.A., Adhikari N.K.J., Kho M.E., Meade M.O., Cook D.J., et al. The design and interpretation of pilot trials in clinical research in critical care. Crit Care Med 2009, 37:S69-S74.
12. Thabane L., Ma J., Chu R., Cheng J., Ismaila A., Rios L.P., et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol 2010, 10:1.
13. Kraemer H.C., Mintz J., Noda A., Tinklenberg J., Yesavage J.A. Caution regarding the use of pilot studies to guide power calculations for study proposals. Arch Gen Psychiatry 2006, 63:484-489.
14. Sim J., Lewis M. The size of a pilot study for a clinical trial should be calculated in relation to considerations of precision and efficiency. J Clin Epidemiol 2012, 65:301-308.
15. Brower R.G., Shanholtz C.B., Fessler H.E., Shade D.M., White P., Wiener C.M., et al. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999, 27:1492-1498.
16. Fan E., Needham D.M., Stewart T.E. Ventilatory management of acute lung injury and acute respiratory distress syndrome. JAMA 2005, 294:2889-2896.