Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats

Biological Psychiatry

Volumn 76, Issue 1, 2014, Pages 8-14

  Ramôa, Carolina P ^a   Doyle, Susan E ^a   Lycas, Matthew D ^a   Chernau, Andrea K ^a   Lynch, Wendy J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cocaine; estradiol; extended access; nucleus accumbens; SCH 23390; self administration

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; COCAINE; DOPAMINE 1 RECEPTOR; ESTRADIOL; SUCROSE; BENZAZEPINE DERIVATIVE; DOPAMINE RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; DRUG WITHDRAWAL; EXPERIMENTAL DISEASE; FEMALE; MALE; MOTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; ADDICTION; ANIMAL; DRUG EFFECTS; INSTRUMENTAL CONDITIONING; MICROINJECTION; NUCLEUS ACCUMBENS; OVARIECTOMY; PATHOPHYSIOLOGY; PHYSIOLOGY; REINFORCEMENT;

ANIMALS; BEHAVIOR, ADDICTIVE; BENZAZEPINES; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; ESTRADIOL; FEMALE; MALE; MICROINJECTIONS; NUCLEUS ACCUMBENS; OVARIECTOMY; PHENOTYPE; RATS; RECEPTORS, DOPAMINE D1; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION;

EID: 84902185360     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.09.028     Document Type: Article

References (65)

1. P.W. Kalivas, and N.D. Volkow The neural basis of addiction: A pathology of motivation and choice Am J Psychiatry 162 2005 1403 1413
2. G.F. Koob, and N.D. Volkow Neurocircuitry of addiction Neuropsychopharmacology 35 2009 217 238
3. E.J. Nestler The neurobiology of cocaine addiction Sci Pract Perspect 3 2005 4 10
4. R.C. Pierce, and V. Kumaresan The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse Neurosci Behav Rev 30 2006 215 238
5. I. Willuhn, M.J. Wanat, J.J. Clark, and P.E. Phillips Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse Curr Top Behav Neurosci 3 2010 29 71
6. E. Carboni, A. Imperato, L. Perezzani, and G. Di Chiara Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats Neuroscience 28 1989 653 661
7. G. Di Chiari, and A. Imperato Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc Natl Acad Sci U S A 85 1988 5274 5278
8. L. Hernandez, and B.G. Hoebel Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis Life Sci 42 1988 1705 1712
9. R.K. Bathcell, K. Whisler, D. Karanian, and D.W. Self Effects of intranucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat Psychopharmacology 183 2005 41 53
10. S.B. Caine, S.C. Heinrichs, V.L. Coffin, and G.F. Koob Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat Brain Res 692 1995 47 56
11. A. McGregor, and D.C. Roberts Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on the intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement Brain Res 624 1993 245 252
12. A.A. Bari, and R.C. Pierce D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement Neuroscience 135 2005 959 968
13. R. Maldonado, P. Robledo, A.J. Chover, S.B. Caine, and G.F. Koob D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat Pharmacol Biochem Behav 45 1993 239 242
14. P. Robledo, R. Maldonado-Lopez, and G.F. Koob Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine Ann N Y Acad Sci 654 1992 509 512
15. D.A. Baker, R.A. Fuchs, S.E. Specio, T.V. Khroyan, and J.L. Neisewander Effects of intraaccumbens administration of SCH-23390 on cocaine-induced locomotion and conditioned place preference Synapse 30 1998 181 193
16. L.G. Laurier, W.A. Corrigall, and S.R. George Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat Brain Res 634 1994 31 40
17. R.J. Moore, S.L. Vinsant, M.A. Nader, L.J. Porrino, and D.P. Friedman Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys Synapse 28 1998 1 9
18. M. Graziella De Montis, C. Co, S.I. Dworkin, and J.E. Smith Modifications of dopamine D1 receptor complex in rats self-administering cocaine Eur J Pharmacol 362 1998 9 15
19. W.J. Lynch, and J.R. Taylor Persistent changes in motivation to self†administer cocaine following modulation of cyclic AMP†dependent protein kinase A (PKA) activity in the nucleus accumbens Eur J Neurosci 22 2005 1214 1220
20. D.W. Self, L.M. Genova, B.T. Hope, W.J. Barnhart, J.J. Spencer, and E.J. Nestler Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior J Neurosci 18 1998 1848 1859
21. S.B. Caine, M. Thomsen, K.I. Gabriel, J.S. Berkowitz, L.H. Gold, and G.F. Koob et al. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice J Neurosci 27 2007 13140 13150
22. J. Zhang, L. Zhang, J. Jiao, Q. Zhang, D. Zhang, and M. Xu et al. c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes J Neurosci 26 2006 13287 13296
23. S.M. Anderson, and R.C. Pierce Cocaine-induced alterations in dopamine receptor signaling: Implications for reinforcement and reinstatement Pharmacol Ther 106 2005 389 403
24. T.E. Koeltzow, and F.J. White Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons Behav Neurosci 117 2003 860
25. I.M. Maisonneuve, A. Ho, and M.J. Kreek Chronic administration of a cocaine" binge" alters basal extracellular levels in male rats: an in vivo microdialysis study J Pharmacol Exp Ther 272 1995 652 657
26. P.E. Paulson, D.M. Camp, and T.E. Robinson Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats Psychopharmacology 103 1991 480 492
27. J. Chao, and E.J. Nestler Molecular neurobiology of drug addiction Annu Rev Med 55 2004 113 132
28. M. Melis, S. Spiga, and M. Diana The dopamine hypothesis of drug addiction: Hypodopaminergic state Int Rev Neurobiol 63 2005 101 154
29. M.E. Wolf, S. Mangiavacchi, and X. Sun Mechanisms by which dopamine receptors may influence synaptic plasticity Acad Sci 1003 2003 241 249
30. D.C. Roberts, D. Morgan, and Y. Liu How to make a rat addicted to cocaine Prog Neuropsychopharmacol Biol Psychiatry 31 2007 1614 1624
31. S.H. Ahmed The science of making drug-addicted animals Neuroscience 211 2012 107 125
32. Y. Liu, D.C. Roberts, and D. Morgan Sensitization of the reinforcing effects of self-administered cocaine in rats: Effects of dose and intravenous injection speed Eur J Neurosci 22 2005 195 200
33. D. Morgan, K. Brebner, W.J. Lynch, and D.C. Roberts Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement Behav Pharmacol 13 2002 389 396
34. W.J. Lynch, and J.R. Taylor Sex differences in the behavioral effects of 24-hr access to cocaine under a discrete trial procedure Neuropsychopharmacology 29 2004 943 951
35. C.P. Ramôa, S.E. Doyle, D.W. Naim, and W.J. Lynch Estradiol as a mechanism for sex differences in the development of an addicted phenotype following extended access cocaine self-administration Neuropsychopharmacology 38 2013 1698 1705
36. A. Segarra, J. Agosto-Rivera, M. Febo, N. Lugo-Escobar, R. Menéndez-Delmestre, and A. Puig-Ramos et al. Estradiol: A key biological substrate mediating the response to cocaine in female rats Horm Behav 58 2010 33 43
37. M. Hu, and J.B. Becker Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration Drug Alcohol Depend 94 2008 56 62
38. W.J. Lynch, M.E. Roth, and M.E. Carroll Biological basis of sex differences in drug abuse: Preclinical and clinical studies Psychopharmacology 164 2002 121 137
39. E.B. Larson, J.J. Anker, L.A. Gliddon, K.S. Fons, and M.E. Carroll Effects of estrogen and progesterone on the escalation of cocaine self-administration in female rats during extended access Exper Clin Psychopharmacol 15 2007 461
40. W.J. Lynch, M.E. Roth, J.L. Mickelberg, and M.E. Carroll Role of estrogen in the acquisition of intravenously self-administered cocaine in female rats Pharmacol Biochem Behav 68 2001 641 646
41. L.R. Jackson, T.E. Robinson, and J.B. Becker Sex differences and hormonal influences on acquisition of cocaine self-administration in rats Neuropsychopharmacology 31 2006 129 138
42. J.B. Becker Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis Neurosci Lett 118 1990 169 171
43. J.B. Becker Gender differences in dopaminergic function in striatum and nucleus accumbens Pharmacol Biochem Behav 64 1999 803 812
44. L. Xiao, and J.B. Becker Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: Effects of estrous cycle and gonadectomy Neurosci Lett 180 1994 155 158
45. J.R. Taylor, W.J. Lynch, H. Sanchez, P. Olausson, E.J. Nestler, and J.A. Bibb Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine Proc Natl Acad Sci U S A 104 2007 4147 4152
46. O. Ben-Shahar, P. Keeley, M. Cook, W. Brake, M. Joyce, and M. Nyffeler et al. Changes in levels of D1, D2, or NMDA receptors during withdrawal from brief or extended daily access to IV cocaine Brain Res 1131 2007 220 228
47. L.A. Briand, S.B. Flagel, M.J. Garcia-Fuster, S.J. Watson, H. Akil, and M. Sarter et al. Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine Neuropsychopharmacology 33 2008 2969 2980
48. Y. Mateo, C.M. Lack, D. Morgan, D.C. Roberts, and S.R. Jones Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation Neuropsychopharmacology 30 2005 1455 1463
49. S.H. Ahmed, D. Lin, G.F. Koob, and L.H. Parsons Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels J Neurochem 86 2003 102 113
50. S.H. Ahmed, and G.F. Koob Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake Psychopharmacology 172 2004 450 454
51. J.J. Anker, and M.E. Carroll Females are more vulnerable to drug abuse than males: Evidence from preclinical studies and the role of ovarian hormones Curr Top Behav Neurosci 8 2011 73 96
52. J.B. Becker, and M. Hu Sex differences in drug abuse Front Neuroendocrinol 29 2008 36 47
53. E.D. Festa, and V. Quinones-Jenab Gonadal hormones provide the biological basis for sex differences in behavioral responses to cocaine Horm Behav 46 2004 509 519
54. M. Hu, H.S. Crombag, T. Robinson, and J.B. Becker Biological basis of sex differences in the propensity to self-administer cocaine Neuropsychopharmacology 29 2004 81 85
55. W.J. Lynch, and M.E. Carroll Sex differences in the acquisition of intravenously self-administered cocaine and heroin rats Psychopharmacology 144 1999 77 82
56. V. Quinones-Jenab, and S. Jenab Influence of sex differences and gonadal hormones on cocaine addiction ILAR J 53 2012 14 22
57. T.L. Thompson, and R.L. Moss Estrogen regulation of dopamine release in the nucleus accumbens: Genomic- and nongenomic-mediated effects J Neurochem 62 1994 1750 1756
58. E. Festa, S. Jenab, J. Weiner, A. Nazarian, T. Niyomchai, and S.J. Russo et al. Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration Brain Res Bull 68 2006 277 284
59. W.J. Lynch, D.D. Kiraly, B.J. Caldarone, M.R. Picciotto, and J.R. Taylor Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats Psychopharmacology 191 2007 263 271
60. A.P. Auger, J.M. Meredith, G.L. Snyder, and J.D. Blaustein Oestradiol increases phosphorylation of a dopamine†and cyclic AMP†regulated phosphoprotein (DARPP†32) in female rat brain J Neuroend 13 2001 761 768
61. J.M. Meredith, C.A. Moffatt, A.P. Auger, G.L. Snyder, P. Greengard, and J.D. Blaustein Mating-related stimulation induces phosphorylation of dopamine-and cyclic AMP-regulated phosphoprotein-32 in progestin receptor-containing areas in the female rat brain J Neurosci 18 1998 10189 10195
62. W.L. Woolverton Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys Pharmacol Biochem Behav 24 1986 531 535
63. J. Bergman, J.B. Kamien, and R.D. Spealman Antagonism of cocaine self-administration by selective dopamine D(1) and D(2) antagonists Behav Pharmacol 1 1990 355 363
64. C.L. Pickens, M. Airavaara, F. Theberge, S. Fanous, B.T. Hope, and Y. Shaham Neurobiology of the incubation of drug craving Trends Neurosci 34 2011 411 420
65. P.W. Kalivas, and K. McFarland Brain circuitry and the reinstatement of cocaine-seeking behavior Psychopharmacology 168 2003 44 56