HPV infection in HIV-positive females: The need for cervical cancer screening including HPV-DNA detection despite successful HAART

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 8, 2014, Pages 1277-1285

  Madeddu, G ^a   Mameli, G ^a   Capobianco, G ^a   Babudieri, S ^a   Maida, I ^a   Bagella, P ^a   Rocca, G ^a   Cherchi, P L ^a   Sechi, L A ^a   Zanetti, S ^a   Nunnari, G ^b   Dessole, S ^a   Mura, M S ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Cervical cancer; HAART; HIV; HPV

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS DNA; VIRUS RNA;

ADULT; ARTICLE; CANCER SCREENING; CD4 LYMPHOCYTE COUNT; CLINICAL EVALUATION; COLPOSCOPY; CONTROLLED STUDY; FEMALE; GENOTYPE; GROUPS BY AGE; HEPATITIS B; HEPATITIS C; HIGH RISK PATIENT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN PAPILLOMAVIRUS DNA TEST; HUMAN TISSUE; INTERMEDIATE RISK PATIENT; INTRAVENOUS DRUG ABUSE; INVASIVE CERVICAL CANCER; LOW RISK PATIENT; MAJOR CLINICAL STUDY; MIXED INFECTION; NUCLEIC ACID HYBRIDIZATION; SEXUAL INTERCOURSE; STUDY DESIGN; TREATMENT DURATION; UTERINE CERVIX CANCER; UTERINE CERVIX CYTOLOGY; VERRUCA VULGARIS; VIRUS TRANSMISSION; CERVICAL INTRAEPITHELIAL NEOPLASIA; COMPARATIVE STUDY; CYTODIAGNOSIS; EARLY DIAGNOSIS; GENETICS; HIV INFECTIONS; PAPILLOMA VIRUS; PAPILLOMAVIRUS INFECTIONS; PATHOLOGY; PHENOTYPE; PREDICTIVE VALUE; PROCEDURES; RISK FACTOR; UTERINE CERVICAL NEOPLASMS; VIROLOGY;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CERVICAL INTRAEPITHELIAL NEOPLASIA; COINFECTION; CYTODIAGNOSIS; DNA, VIRAL; EARLY DETECTION OF CANCER; FEMALE; GENOTYPE; HIV INFECTIONS; HUMAN PAPILLOMAVIRUS DNA TESTS; HUMANS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RISK FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 84902173363     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Immunization, Vaccines and Biologicals, HPV, WHO 2008. http://www.who.int/immunization/topics/hpv/en/ accessed 16 April 2013.
2. RONCO G, GHISETTI V, SEGNAN N, SNIJDERS PJ, GILLIO-TOS A, MEIJER CJ, MERLETTI F, FRANCESCHI S. Prevalence of human papillomavirus infection in women in Turin, Italy. Eur J Cancer 2005; 41: 297-305. (Pubitemid 40126963)
3. KOUTSKY L. Epidemiology of genital human papillomavirus infection. Am J Med 1997; 102: 3-8. (Pubitemid 127695953)
4. UNAIDS Report on the global AIDS epidemic 2012. http://www.unaids.org/en/ media/unaids/contentassets/documents/epidemiology/2012/gr2012/ 20121120-UNAIDS-Global-Report-2012. Accessed 16 April 2013.
5. NOTIZIARIO DELL'ISTITUTO SUPERIORE DI SANITÀ. Aggiornamento delle nuove diagnosi di infezione da HIV e dei casi di AIDS in Itala al 31 Dicembre 2011. 2012; 25(Suppl. 1): 1-47.
6. STRICKLER HD, BURK RD, FAZZARI M, ANASTOS K, MINKOFF H, MASSAD LS, HALL C, BACON M, LEVINE AM, WATTS DH, SILVERBERG MJ, XUE X, SCHLECHT NF, MELNICK S, PALEFSKY JM. Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst 2005; 20: 577-586. (Pubitemid 40723785)
7. PALEFSKY JM, MINKOFF H, KALISH LA, LEVINE A, SACKS HS, GARCIA P, YOUNG M, MELNICK S, MIOTTI P, BURK R. Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. J Natl Cancer Inst 1999; 91: 226-236. (Pubitemid 29090991)
8. LA FERLA L, PINZONE MR, NUNNARI G, MARTELLOTTA F, LLESHI A, TIRELLI U, DE PAOLI P, BERRETTA M, CACOPARDO B. Kaposi? s sarcoma in HIV-positive patients: the state of art in the HAART-era. Eur Rev Med Pharmacol Sci 2013; 17: 2354-2365.
9. MADEDDU G, SPANU A, SOLINAS P, CALIA G M, LOVIGU C, MANNAZZU M, FALCHI A, MURA MS, MADEDDU G. Bone mineral loss and vitamin D metabolism impairment in HIV infected patients receiving highly active antiretroviral therapy (HAART). Q J Nucl Med Mol Imaging 2004; 48: 39-48. (Pubitemid 39069663)
10. MADEDDU G, SPANU A, CHESSA F, CALIA GM, LOVIGU C, SOLINAS P, MANNAZZU M, FALCHI A, MURA MS, MADEDDU G. Thyroid function in human immunodeficiency virus patients treated with highly active antiretroviral therapy (HAART): a longitudinal study. Clin Endocrinol 2006; 64: 375-383.
11. BONFANTI P, RICCI E, DE SOCIO G, ZEME D, CARRADORI S, PENCO G, PARRUTI G, GROSSO C, MADEDDU G, VICHI F, BINI T, MARTINELLA C, MELZI S, QUIRINO T, CISAI STUDY GROUP. Metabolic syndrome: a real threat for HIV-positive patients?: Results from the SIMONE study. J Acquir Immune Defic Syndr 2006; 42: 128-131. (Pubitemid 43947959)
12. BONFANTI P, DE SOCIO GL, MARCONI P, FRANZETTI M, MARTINELLI C, VICHI F, BINI T, MARTINELLI C, MELZI S, QUIRINO T; CISAI STUDY GROUP. Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study. Curr HIV Res 2010; 8: 165-171.
13. DE SOCIO GV, RICCI E, PARRUTI G, MAGGI P, MADEDDU G, QUIRINO T, BONFANTI P. Chronological and biological age in HIV infection. J Infect 2010; 61: 428-430.
14. BONFANTI P, DE SOCIO GV, RICCI E, ANTINORI A, MARTINELLI C, VICHI F, PENCO G, MADEDDU G, OROFINO G, VALSECCHI L, RUSCONI S, MENZAGHI B, POCATERRA D, QUIRINO T. The feature of Metabolic Syndrome in HIV naive patients is not the same of those treated: results from a prospective study. Biomed Pharmacother 2012; 66: 348-353.
15. MADEDDU G, FOIS AG, CALIA GM, BABUDIERI S, SODDU V, BECCIU F, FIORI ML, SPADA V, LOVIGU C, MANNAZZU M, CADDEO A, PIRAS B, PIRINA P, MURA MS. Chronic obstructive pulmonary disease: an emerging comorbidity in HIV-infected patients in the HAART era? Infection 2013; 41: 347-353.
16. SCHILLACI G, MAGGI P, MADEDDU G, PUCCI G, MAZZOTTA E, PENCO G, OROFINO G, MENZAGHI B, RUSCONI S, CARENZI L, CELESIA BM, MARTINELLI C, BONFANTI P, DE SOCIO GV; CISAI STUDY GROUP. Symmetric ambulatory arterial stiffness index and 24-h pulse pressure in HIV infection: results of a nationwide cross-sectional study. J Hypertens 2013; 31: 560- 567; discussion 567.
17. ZANET E, BERRETTA M, MARTELLOTTA F, CACOPARDO B, FISICHELLA R, TAVIO M, BERRETTA S, TIRELLI U. Anal cancer: Focus on HIV-positive patients in the HAART-era. Curr HIV Res 2011; 9: 70-81.
18. PINZONE MR, FIORICA F, DI ROSA M, MALAGUARNERA G, MALAGUARNERA L, CACOPARDO B, NUNNARI G. Non- AIDS-defining cancers among HIV-infected people. Eur Rev Med Pharmacol Sci 2012; 16: 1377-1388.
19. BERRETTA M, CINELLI R, MARTELLOTTA F, SPINA M, VACCHER E, TIRELLI U. Therapeutic approaches to AIDS-related malignancies. Oncogene 2003; 22: 6646-6659. (Pubitemid 37372345)
20. MARTELLOTTA F, BERRETTA M, CACOPARDO B, FISICHELLA R, SCHIOPPA O, ZANGHÌ A, SPARTÀ D, CAPPELLANI A, TALAMINI R, IZZI I, RIDOLFO A, TORRESIN A, FIORICA F, TIRELLI U. Clinical presentation and outcome of squamous cell carcinoma of the anus in HIV-infected patients in the HAART-era: a GICAT experience. Eur Rev Med Pharmacol Sci 2012; 16: 1283-1291.
21. SIMONELLI C, TEDESCHI R, GLOGHINI A, TALAMINI R, BORTOLIN MT, BERRETTA M, SPINA M, MORASSUT S, VACCHER E, DE PAOLI P, CARBONE A, TIRELLI U. Plasma HHV-8 viral load in HHV-8-related lymphoproliferative disorders associated with HIV infection. J Med Virol 2009; 81: 888-896.
22. BERRETTA M, GARLASSI E, CACOPARDO B, CAPPELLANI A, GUARALDI G, COCCHI S, DE PAOLI P, LLESHI A, IZZI I, TORRESIN A, DI GANGI P, PIETRANGELO A, FERRARI M, BEARZ A, BERRETTA S, NASTI G, DI BENEDETTO F, BALESTRERI L, TIRELLI U, VENTURA P. Hepatocellular carcinoma in HIV-infected patients: check early, treat hard. Oncologist 2011; 16: 1258-1269.
23. BERRETTA M, ZANET E, BASILE F, RIDOLFO AL, DI BENEDETTO F, BEARZ A, BERRETTA S, NASTI G, TIRELLI U. HIV-positive patients with liver metastases from colorectal cancer deserve the same therapeutic approach as the general population. Onkologie 2010; 33: 203-204.
24. BERRETTA M, LLESHI A, CAPPELLANI A, BEARZ A, SPINA M, TALAMINI R, CACOPARDO B, NUNNARI G, MONTESARCHIO V, IZZI I, LANZAFAME M, NASTI G, BASILE F, BERRETTA S, FISICHELLA R, SCHIANTARELLI C C, GARLASSI E, RIDOLFO A, GUELLA L, TIRELLI U. Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection. Curr HIV Res 2010; 8: 218-222.
25. SCARPINO M, PINZONE MR, DI ROSA M, MADEDDU G, FOCÀ E, MARTELLOTTA F, SCHIOPPA O, CECCARELLI G, CELESIA BM, D'ETTORRE G, VULLO V, BERRETTA S, CACOPARDO B, NUNNARI G. Kidney disease in HIV-infected patients. Eur Rev Med Pharmacol Sci 2013; 17: 2660-2667.
26. CASTRONUOVO D, CACOPARDO B, PINZONE MR, DI ROSA M, MARTELLOTTA F, SCHIOPPA O, MORENO S, NUNNARI G. Bone disease in the setting of HIV infection: update andreview of the literature. Eur Rev Med Pharmacol Sci 2013; 17: 2413-2419.
27. NUNNARI G, BERRETTA M, PINZONE MR, DI ROSA M, BERRETTA S, CUNSOLO G,MALAGUARNERA M, COSENTINO S, DE PAOLI P, SCHNELL JM, CACOPARDO B. Hepatocellular carcinoma in HIV positive patients. Eur Rev Med Pharmacol Sci 2012; 16: 1257-1270.
28. ZANET E, BERRETTA M, BENEDETTO FD, TALAMINI R, BALLARIN R, NUNNARI G, BERRETTA S, RIDOLFO A, LLESHI A, ZANGHÌ A, CAPPELLANI A, TIRELLI U. Pancreatic cancer in HIV-positive patients: a clinical case-control study. Pancreas 2012; 41: 1331-1335.
29. PINZONE MR, DI ROSA M, CACOPARDO B, NUNNARI G. HIV RNA suppression and immune restoration: can we do better? Clin Dev Immunol 2012; 2012: 515962.
30. PINZONE MR, DI ROSA M, MALAGUARNERA M, MADEDDU G, FOCÀ E, CECCARELLI G, D'ETTORRE G, VULLO V, FISICHELLA R, CACOPARDO B, NUNNARI G. Vitamin D deficiency in HIV infection: an underestimated and undertreated epidemic. Eur Rev Med Pharmacol Sci 2013; 17: 1218-1232.
31. KEISER O, MARTINEZ DE TEJADA B, WUNDER D, CHAPUIS-TAILLARD C, ZELLWEGER C, ZINKERNAGEL AS, ELZI L, SCHMID P, BERNASCONI E, AEBI-POPP K, RICKENBACH M. Frequency of gynecologic follow-up and cervical cancer screening in the Swiss HIV cohort study. J Acquir Immune Defic Syndr 2006; 43: 550-555. (Pubitemid 44885621)
32. COBO F, GARCÍA C, TALAVERA P, BRAVO J, CABRERA C, CONCHA A. Human papillomavirus associated with papillary squamous cell carcinoma of the oropharynx in a renal transplant recipient. Infection 2006; 34: 176-180. (Pubitemid 43979669)
33. FRANCESCHI S, JAFFE H. Cervical cancer screening of women living with HIV infection: a must in the era of antiretroviral therapy. Clin Infect Dis 2007; 45: 510-513. (Pubitemid 47204472)
34. The 1988 Bethesda System for reporting cervical/vaginal cytological diagnoses. National Cancer Institute Workshop. JAMA 1989; 262: 931-934.
35. BRODER S. From the National Institutes of Health. JAMA 1992; 267: 1892.
36. SOLOMON D, DAVEY D, KURMAN R, MORIARTY A, O'CONNOR D, PREY M, RAAB S, SHERMAN M, WILBUR D, WRIGHT T JR, YOUNG N; FORUM GROUP MEMBERS; BETHESDA 2001 WORKSHOP. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA 2002; 287: 2114-219.
37. CLIFFORD GM, GONCALVES MA, FRANCESCHI S. Human papillomavirus types among women infected with HIV: a meta-analysis. AIDS 2006; 20: 2337-2344. (Pubitemid 44789536)
38. HASSEN E, CHAIEB A, LETAIEF M, KHAIRI H, ZAKHAMA A, REMADI S, CHOUCHANE L. Cervical human papillomavirus infection in Tunisian women. Infection 2003; 31: 143-148. (Pubitemid 36737034)
39. HEARD I, CUBIE HA, MESHER D, SASIENI P; MACH-1 STUDY GROUP. Characteristics of HPV infection over time in European women who are HIV-1 positive. BJOG 2013; 120: 41-49.
40. EUROPEAN AIDS CLINICAL SOCIETY GUIDELINES. Version 6.1-November 2012. http://www.europeanaidsclinicalsociety.org/images/stories/EACSPdf/ EacsGuidelines-v6.1-2edition.pdf
41. SASLOW D, SOLOMON D, LAWSON HW, KILLACKEY M, KULASINGAM SL, CAIN J, GARCIA FA, MORIARTY AT, WAXMAN AG, WILBUR DC, WENTZENSEN N, DOWNS LS JR, SPITZER M, MOSCICKI AB, FRANCO EL, STOLER MH, SCHIFFMAN M, CASTLE PE, MYERS ER; American Cancer Society; American Society for Colposcopy and Cervical Pathology; American Society for Clinical Pathology. American Cancer Society; American Society for Colposcopy and Cervical Pathology; American Society for Clinical Pathology. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol 2012; 137: 516-542.
42. GARBUGLIA AR, PISELLI P, LAPA D, SIAS C, DEL NONNO F, BAIOCCHINI A, CIMAGLIA C, AGRESTA A, CAPOBIANCHI MR. Frequency and multiplicity of human papillomavirus infection in HIV-1 positive women in Italy. J Clin Virol 2012; 54: 141-146.
43. HEARD I, PALEFSKY JM, KAZATCHKINE MD. The impact of HIV antiviral therapy on human papillomavirus (HPV) infections and HPV-related diseases. Antivir Ther 2004; 9: 13-22. (Pubitemid 38313943)
44. HEARD I, SCHMITZ V, COSTAGLIOLA D, ORTH G, KAZATCHKINE MD. Early regression of cervical lesions in HIV-seropositive women receiving highly active antiretroviral therapy. AIDS 1998; 12: 1459-1464. (Pubitemid 28369645)
45. HEARD I, POTARD V, COSTAGLIOLA D. Limited impact of immunosuppression and HAART on the incidence of cervical squamous intraepithelial lesions in HIV-positive women. Antivir Ther 2006; 11: 1091-1096. (Pubitemid 44955185)
46. SONCINI E, ZONCADA A, CONDEMI V, ANTONI AD, BOCCHIALINI E, SOREGOTTI P. Reduction of the risk of cervical intraepithelial neoplasia in HIV-infected women treated with highly active antiretroviral therapy. Acta Biomed 2007; 78: 36-40.
47. SIRERA G, VIDELA S, LÓPEZ-BLÁZQUEZ R, LLATJOS M, TARRATS A, CASTELLÀ E, GRANE N, TURAL C, REY-JOLY C, CLOTET B. Highly active antiretroviral therapy and incidence of cervical squamous intraepithelial lesions among HIV-infected women with normal cytology and CD4 counts above 350 cells/mm3. J Antimicrob Chemother 2008; 61: 191-194.
48. LEHTOVIRTA P, PAAVONEN J, HEIKINHEIMO O. Risk factors, diagnosis and prognosis of cervical intraepithelial neoplasia among HIV-infected women. Int J STD AIDS 2008; 19: 37-41. (Pubitemid 351738841)
49. FRANCESCHI S, DAL MASO L, SULIGOI B, REZZA G. Evidence for lack of cervical cancer screening among HIV-positive women in Italy. Eur J Cancer Prev 2006; 15: 554-556. (Pubitemid 44757831)
50. RODEN R, WU TC. How will HPV vaccines affect cervical cancer? Nat Rev Cancer 2006; 6: 753-763. (Pubitemid 44450464)
51. PIANA A, SOTGIU G, CASTIGLIA P, PISCHEDDA S, COCUZZA C, CAPOBIANCO G, ET AL. Prevalence and type distribution of human papillomavirus infection in women from North Sardinia, Italy. BMC Public Health 2011; 11: 785.
52. LEVIN MJ, MOSCICKI AB, SONG LY, FENTON T, MEYER WA 3RD, READ JS, ET AL. Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years old. J Acquir Immune Defic Syndr 2010; 55: 197-204.
53. LA FERLA L, PINZONE MR, NUNNARI G, MARTELLOTTA F, LLESHI A, TIRELLI U, DE PAOLI P, BERRETTA M, CACOPARDO B. Kaposi' s sarcoma in HIV-positive patients: the state of art in the HAART-era. Eur Rev Med Pharmacol Sci 2013; 17: 2354-2365.
54. BERRETTA M, DI BENEDETTO F, DAL MASO L, CACOPARDO B, NASTI G, FACCHINI G, BEARZ A, SPINA M, GARLASSI E, DE RE V, FIORICA F, LLESHI A, TIRELLI U. Sorafenib for the treatment of unresectable hepatocellular carcinoma in HIV-positive patients. Anticancer Drugs 2013; 24: 212-218.
55. BERRETTA M, CAPPELLANI A, DI BENEDETTO F, LLESHI A, TALAMINI R, CANZONIERI V, ZANET E, BEARZ A, NASTI G, LACCHIN T, BERRETTA S, FISICHELLA R, BALESTRERI L, TORRESIN A, IZZI I, ORTOLANI P, TIRELLI U. Clinical presentation and outcome of colorectal cancer in HIVpositive patients: a clinical case-control study. Onkologie 2009; 32: 319-324.
56. BEARZ A, VACCHER E, TALAMINI R, BERRETTA M, TIRELLI U. Comment on 'Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection'. Br J Cancer 2012; 106: 1899-900.
57. BERRETTA M, ZANET E, DI BENEDETTO F, SIMONELLI C, BEARZ A, MORRA A, BONANNO S, BERRETTA S, TIRELLI U. Unusual presentation of metastatic hepatocellular carcinoma in an HIV/HCV coinfected patient: case report and review of the literature. Tumori 2008; 94: 589-591.
58. DI BENEDETTO F, DI SANDRO S, DE RUVO N, BERRETTA M, MONTALTI R, GUERRINI GP, BALLARIN R, DE BLASIIS MG, SPAGGIARI M, SMERIERI N, IEMMOLO RM, GUARALDI G, GERUNDA GE. Human immunodeficiency virus and liver transplantation: our point of view. Transplant Proc 2008; 40: 1965-1971.
59. BERRETTA M, DI BENEDETTO F, BEARZ A, SIMONELLI C, MARTELLOTTA F, DEL BEN C, BERRETTA S, SPINA M, TIRELLI U. FOLFOX-4 regimen with concomitant highly active antiretroviral therapy in metastatic colorectal cancer HIV-infected patients: a report of five cases and review of the literature. Cancer Invest 2008; 26: 610-614. (Pubitemid 351918581)
60. DI BENEDETTO F, DI SANDRO S, DE RUVO N, BERRETTA M, MASETTI M, MONTALTI R, BALLARIN R, COCCHI S, POTENZA L, LUPPI M, GERUNDA GE. Kaposi's sarcoma after liver transplantation. J Cancer Res Clin Oncol 2008; 134: 653-658. (Pubitemid 351506416)