Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 7, 2014, Pages 1512-1518

  Nagae, Masamichi ^a   Ikeda, Akemi ^a   Kitago, Yu ^b   Matsumoto, Naoki ^c   Yamamoto, Kazuo ^c   Yamaguchi, Yoshiki ^a  

^a RIKEN   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

BDCA2; C type lectin; Carbohydrate recognition domain; Crystal structure; Dendritic cell; Dimer; Domain swapping

Indexed keywords

BLOOD DENDRITIC CELL ANTIGEN 2; CALCIUM ION; CARBOHYDRATE BINDING PROTEIN; CELL ANTIGEN; DIMER; LECTIN RECEPTOR; MANNOSE RECEPTOR; SNAKE VENOM; UNCLASSIFIED DRUG; CALCIUM; CLEC4C PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; LECTIN; MEMBRANE PROTEIN; PROTEIN SUBUNIT;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE RECOGNITION DOMAIN; CRYSTAL STRUCTURE; CRYSTALLIZATION; DENDRITIC CELL; DIMERIZATION; DISULFIDE BOND; HANGING DROP VAPOR DIFFUSION METHOD; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; X RAY DIFFRACTION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN SUBUNIT; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; LECTINS, C-TYPE; MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, IMMUNOLOGIC; SEQUENCE ALIGNMENT;

EID: 84902166527     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24504     Document Type: Article

References (24)

1. Zelensky AN, Gready JE. The C-type lectin-like domain superfamily. FEBS J 2005;272:6179-6217.
2. Drickamer K. C-type lectin-like domains. Curr Opin Struct Biol 1999;9:585-590.
3. Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T. Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains. Nat Struct Biol 1997;4:438-441.
4. Mizuno H, Fujimoto Z, Atoda H, Morita T. Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X. Proc Natl Acad Sci USA 2001;98:7230-7234.
5. Feinberg H, Park-Snyder S, Kolatkar AR, Heise CT, Taylor ME, Weis WI. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J Biol Chem 2000;275:21539-21548.
6. Kolenko P, Rozbesky D, Vanek O, Kopecky V, Jr., Hofbauerova K, Novak P, Pompach P, Hasek J, Skalova T, Bezouska K, Dohnalek J. Molecular architecture of mouse activating NKR-P1 receptors. J Struct Biol 2011;175:434-441.
7. Ogawa T, Chijiwa T, Oda-Ueda N, Ohno M. Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom. Toxicon 2005;45:1-14.
8. Taylor PR, Gordon S, Martinez-Pomares L. The mannose receptor: Linking homeostasis and immunity through sugar recognition. Trends Immunol 2005;26:104-110.
9. Yamasaki M, Li W, Johnson DJ, Huntington JA. Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature 2008;455:1255-1258.
10. Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, Gunther G, Johnston I, Lanzavecchia A, Nagasaka T, Okada T, Vermi W, Winkels G, Yamamoto T, Zysk M, Yamaguchi Y, Schmitz J. BDCA-2: A novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med 2001;194:1823-1834.
11. Sozzani S, Vermi W, Del Prete A, Facchetti F. Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol 2010;31:270-277.
12. Riboldi E, Daniele R, Parola C, Inforzato A, Arnold PL, Bosisio D, Fremont DH, Bastone A, Colonna M, Sozzani S. Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. J Biol Chem 2011;286:35329-35333.
13. Cao W, Zhang L, Rosen DB, Bover L, Watanabe G, Bao M, Lanier LL, Liu YJ. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol 2007;5:e248.
14. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 2011;472:471-475.
15. Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TB. Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. Nat Immunol 2009;10:1081-1088.
16. Kabsch W. XDS. Acta Crystallogr D Biol Crystallogr 2010;66:125-132.
17. Vagin A, Teplyakov A. Molecular replacement with MOLREP. Acta Crystallogr D Biol Crystallogr 2010;66:22-25.
18. Nagae M, Yamanaka K, Hanashima S, Ikeda A, Morita-Matsumoto K, Satoh T, Matsumoto N, Yamamoto K, Yamaguchi Y. Recognition of bisecting N-acetylglucosamine: Structural basis for asymmetric interaction with the mouse lectin dendritic cell inhibitory receptor 2. J Biol Chem. 2013;288:33598-33610.
19. Emsley P, Cowtan K. Coot: Model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 2004;60:2126-2132.
20. Murshudov GN, Vagin AA, Dodson EJ. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 1997;53:240-255.
21. Lovell SC, Davis IW, Arendall WB, 3rd, de Bakker PI, Word JM, Prisant MG, Richardson JS, Richardson DC. Structure validation by Cα geometry: φ{symbol}, ψ and Cβ deviation. Proteins 2003;50:437-450.
22. Krissinel E, Henrick K. Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr 2004;60:2256-2268.
23. Yokoyama WM, Plougastel BF. Immune functions encoded by the natural killer gene complex. Nat Rev Immunol 2003;3:304-316.
24. Holla A, Skerra A. Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin. Protein Eng Des Sel 2011;24:659-669.