IL-17 inhibits osteoblast differentiation and bone regeneration in rat

Archives of Oral Biology

Volumn 59, Issue 9, 2014, Pages 897-905

  Kim, Yong Gun ^a   Park, Jin Woo ^a   Lee, Jae Mok ^a   Suh, Jo Young ^a   Lee, Jae Kwan ^b   Chang, Beom Seok ^b   Um, Heung Sik ^b   Kim, Jae Young ^a   Lee, Youngkyun ^a  

^a Kyungpook National University   (South Korea)

^b Gangneung Wonju National University   (South Korea)

Author keywords

Bone formation; Differentiation; IL 17; Rat calvarial osteoblast

Indexed keywords

ALKALINE PHOSPHATASE; INTERLEUKIN 17; MESSENGER RNA; OSTEOCALCIN; OSTERIX PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL; BONE REGENERATION; CELL DIFFERENTIATION; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECTS; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; NEWBORN; OSTEOBLAST; RAT; REAL TIME POLYMERASE CHAIN REACTION; SKULL; SPRAGUE DAWLEY RAT; STAINING;

ALKALINE PHOSPHATASE; ANIMALS; ANIMALS, NEWBORN; BONE REGENERATION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; INTERLEUKIN-17; OSTEOBLASTS; OSTEOCALCIN; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKULL; STAINING AND LABELING; TRANSCRIPTION FACTORS; X-RAY MICROTOMOGRAPHY;

EID: 84902164562     PISSN: 00039969     EISSN: 18791506     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2014.05.009     Document Type: Article

References (15)

1. T.A. Moseley, D.R. Haudenschild, L. Rose, and A.H. Reddi Interleukin-17 family and IL-17 receptors Cytokine Growth Factor Rev 14 2003 155 174 (Pubitemid 36389528)
2. S. Kotake, N. Udagawa, N. Takahashi, K. Matsuzaki, K. Itoh, and S. Ishiyama et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis J Clin Invest 103 1999 1345 1352 (Pubitemid 29218305)
3. S. Shahrara, Q. Huang, A.M. Mandelin 2nd, and R.M. Pope TH-17 cells in rheumatoid arthritis Arthritis Res Ther 10 2008 R93
4. R.B. Johnson, N. Wood, and F.G. Serio Interleukin-11 and IL-17 and the pathogenesis of periodontal disease J Periodontol 75 2004 37 43 (Pubitemid 38312768)
5. S.R. Lester, J.L. Bain, R.B. Johnson, and F.G. Serio Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss J Periodontol 78 2007 1545 1550
6. K. Takahashi, T. Azuma, H. Motohira, D.F. Kinane, and S. Kitetsu The potential role of interleukin-17 in the immunopathology of periodontal disease J Clin Periodontol 32 2005 369 374 (Pubitemid 40569599)
7. R. Vernal, N. Dutzan, A. Chaparro, J. Puente, M. Antonieta Valenzuela, and J. Gamonal Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis J Clin Periodontol 32 2005 383 389 (Pubitemid 40569601)
8. K. Sato, A. Suematsu, K. Okamoto, A. Yamaguchi, Y. Morishita, and Y. Kadono et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction J Exp Med 203 2006 2673 2682 (Pubitemid 44833343)
9. M.A. Eskan, R. Jotwani, T. Abe, J. Chmelar, J.H. Lim, and S. Liang et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss Nat Immunol 13 2012 465 473
10. H. Ohyama, N. Kato-Kogoe, A. Kuhara, F. Nishimura, K. Nakasho, and K. Yamanegi et al. The involvement of IL-23 and the Th17 pathway in periodontitis J Dent Res 88 2009 633 638
11. H. Huang, H.J. Kim, E.J. Chang, Z.H. Lee, S.J. Hwang, and H.M. Kim et al. IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling Cell Death Differ 16 2009 1332 1343
12. R.L. Van bezooijen, H.C. Farih-Sips, S.E. Papapoulos, and C.W. Lowik Interleukin-17. A new bone acting cytokine in vitro J Bone Miner Res 14 1999 1513 1521 (Pubitemid 29416677)
13. M.I. Koenders, E. Lubberts, B. Oppers-Walgreen, L. van den Bersselaar, M.M. Helsen, and F.E. Di Padova et al. Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1 Am J Pathol 167 2005 141 149 (Pubitemid 40884777)
14. J. Kocic, J.F. Santibanez, A. Krstic, S. Mojsilovic, I.O. Dordevic, and D. Trivanovic et al. Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2 Biochim Biophys Acta 1823 2012 838 849
15. X. Song, and Y. Gian The activation and regulation of IL-17 receptor mediated signaling Cytokine 2013 175 182