Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer

Oncology Reports

Volumn 31, Issue 6, 2014, Pages 2587-2592

  Zhang, Xianglan ^a,e   Zheng, Zhenlong ^a,c   Yingji, Shen ^d   Kim, Hyeyeon ^c   Jin, Renshun ^a   Renshu, Li ^a   Lee, Doo Young ^e   Roh, Mi Ryung ^c   Yang, Sanghwa ^b,f  

^a YANBIAN UNIVERSITY   (China)

^b Yonsei University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Shahekou Maternal and Child Hospital   (China)

^e Yonsei University College of Dentistry   (South Korea)

^f GoodGene Inc   (South Korea)

Author keywords

Cervical cancer; Downregulation; GPX3; Lymph node metastasis; Prognosis

Indexed keywords

GLUTATHIONE PEROXIDASE 3; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; GLUTATHIONE PEROXIDASE; GPX3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE FUNCTION; GPX3 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; NUCLEOTIDE SEQUENCE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; PATHOLOGY; PROGNOSIS; UTERINE CERVIX TUMOR;

AZACITIDINE; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE PEROXIDASE; HELA CELLS; HUMANS; LYMPHATIC METASTASIS; PROGNOSIS; PROMOTER REGIONS, GENETIC; UTERINE CERVICAL NEOPLASMS;

EID: 84902159529     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3152     Document Type: Article

References (27)

1. Lodygin D, Epanchintsev A, Menssen A, Diebold J and Hermeking H: Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res 65: 4218-4227, 2005. (Pubitemid 40775660)
2. Brigelius-Flohé R and Kipp A: Glutathione peroxidases in different stages of carcinogenesis. Biochim Biophys Acta 1790: 1555-1568, 2009.
3. Yu YP, Yu G, Tseng G, et al: Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res 67: 8043-8050, 2007. (Pubitemid 47395138)
4. Mikata R, Yokosuka O, Fukai K, et al: Analysis of genes upregulated by the demethylating agent 5-aza-2′-deoxycytidine in gastric cancer cell lines. Int J Cancer 119: 1616-1622, 2006. (Pubitemid 44258767)
5. Lee OJ, Schneider-Stock R, McChesney PA, Kuester D, Roessner A, Vieth M, Moskaluk CA and El-Rifai W: Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia 7: 854-861, 2005.
6. Peng DF, Razvi M, Chen H, et al: DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Gut 58: 5-15, 2009.
7. Zhang X1, Yang JJ, Kim YS, Kim KY, Ahn WS and Yang S: An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. Int J Oncol 36: 405-414, 2010.
8. Saga Y, Ohwada M, Suzuki M, et al: Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep 20: 1299-1303, 2008.
9. Yang ZL, Yang L, Zou Q, et al: Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer. Dis Markers 35: 163-172, 2013.
10. Kaiser MF, Johnson DC, Wu P, et al: Global methylation analysis identifies prognostically important epigenetically inactivated tumour suppressor genes in multiple myeloma. Blood 122: 219-226, 2013.
11. El Haddad M, Jean E, Turki A, et al: Glutathione peroxidase 3, a new retinoid target gene, is crucial for human skeletal muscle precursor cell survival. J Cell Sci 125: 6147-6156, 2012.
12. Barrett CW, Ning W, Chen X, et al: Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res 73: 1245-1255, 2013.
13. Fitzpatrick JM, Schulman C, Zlotta AR and Schröder FH: Prostate cancer: a serious disease suitable for prevention. BJU Int 103: 864-870, 2009.
14. Lu J and Holmgren A: Selenoproteins. J Biol Chem 284: 723-727, 2009.
15. Yang X, Deignan JL, Qi H, et al: Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet 41: 415-423, 2009.
16. Bachtiary B, Boutros PC, Pintilie M, et al: Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin Cancer Res 12: 5632-5640, 2006. (Pubitemid 44629589)
17. He Y, Wang Y, Li P, Zhu S, Wang J and Zhang S: Identification of GPX3 epigenetically silenced by CpG methylation in human esophageal squamous cell carcinoma. Dig Dis Sci 56: 681-688, 2011.
18. Scotto L, Narayan G, Nandula SV, et al: Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression. Genes Chromosomes Cancer 47: 755-765, 2008.
19. Baylin SB and Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6: 107-116, 2006. (Pubitemid 43361543)
20. Esteller M: Epigenetics in cancer. N Engl J Med 358: 1148-1159, 2008.
21. Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428, 2002. (Pubitemid 34587077)
22. Christman JK: 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21: 5483-5495, 2002.
23. Brigelius-Flohé R: Glutathione peroxidases and redox-regulated transcription factors. Biol Chem 387: 1329-1335, 2006.
24. Clark LC, Combs GF Jr, Turnbull BW, et al: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276: 1957-1963, 1996. (Pubitemid 26427723)
25. Dobosy JR, Roberts JL, Fu VX and Jarrard DF: The expanding role of epigenetics in the development, diagnosis and treatment of prostate cancer and benign prostatic hyperplasia. J Urol 177: 822-831, 2007. (Pubitemid 46223571)
26. Jee CD, Kim MA, Jung EJ, Kim J and Kim WH: Identification of genes epigenetically silenced by CpG methylation in human gastric carcinoma. Eur J Cancer 45: 1282-1293, 2009.
27. Maynard S, Schurman SH, Harboe C, de Souza-Pinto NC and Bohr VA: Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis 30: 2-10, 2009.