Could silencing IRF5 improve healing of a myocardial infarct through the reprogramming of the macrophage population?

Journal of the American College of Cardiology

Volumn 63, Issue 15, 2014, Pages 1567-1568

  Hall, Jennifer L ^a   Wei, Li Na ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

IRF5; M1 to M2 transition; macrophage; myocardial infarction

Indexed keywords

INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 10; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

GENE EXPRESSION; GENE SILENCING; HEALING; HEART INFARCTION; HISTOPATHOLOGY; INFLAMMATION; MACROPHAGE; MACROPHAGE FUNCTION; MESENCHYMAL STEM CELL TRANSPLANTATION; NEUTROPHIL COUNT; NONHUMAN; NOTE; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ATHEROSCLEROSIS; CELL MEMBRANE DEPOLARIZATION; CELL METABOLISM; CELL SUBPOPULATION; GENE DELIVERY SYSTEM; HUMAN; IRF5 GENE; MONOCYTE; NEUTROPHIL;

IRF5; M1 TO M2 TRANSITION; MACROPHAGE; MYOCARDIAL INFARCTION;

ANIMALS; GENE EXPRESSION REGULATION; INTERFERON REGULATORY FACTORS; MACROPHAGES; MYOCARDIAL INFARCTION; MYOCARDIUM; RNA; VENTRICULAR REMODELING;

EID: 84902108643     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.11.024     Document Type: Editorial

References (9)

1. G. Courties, T. Heidt, and M. Sebas et al. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing J Am Coll Cardiol 63 2014 1556 1566
2. T. Lawrence, and G. Natoli Transcriptional regulation of macrophage polarization: enabling diversity with identity Nature Rev Immunol 11 2011 750 761
3. D. Tugal, X. Liao, and M.K. Jain Transcriptional control of macrophage polarization Arterioscler Thromb Vasc Biol 33 2013 1135 1144
4. P.C. Ho, Y.C. Tsui, X. Feng, D.R. Greaves, and L.N. Wei NF-kappaB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance Nature Immunol 13 2012 379 386
5. T. Krausgruber, K. Blazek, and T. Smallie et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses Nature Immunol 12 2011 231 238
6. A. Takaoka, H. Yanai, and S. Kondo et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors Nature 434 2005 243 249
7. M. Nahrendorf, and F.K. Swirski Monocyte and macrophage heterogeneity in the heart Circ Res 112 2013 1624 1633
8. Y. Hirata, M. Tabata, and H. Kurobe et al. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue J Am Coll Cardiol 58 2011 248 255
9. T. Ben-Mordechai, R. Holbova, and N. Landa-Rouben et al. Macrophage subpopulations are essential for infarct repair with and without stem cell therapy J Am Coll Cardiol 62 2013 1890 1901