Etiology, clinical features and outcomes of pre-engraftment and post-engraftment bloodstream infection in hematopoietic SCT recipients

Bone Marrow Transplantation

Volumn 49, Issue 6, 2014, Pages 824-830

  Gudiol, C ^a,b   Garcia Vidal, C ^a,b   Arnan, M ^c   Sanchez Ortega I ^c   Patino B ^c   Duarte, R ^c   Carratala J ^a,b  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID;

ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BLOODSTREAM INFECTION; CENTRAL VENOUS CATHETER; DISEASE COURSE; ENGRAFTMENT; FEMALE; GASTROINTESTINAL INFECTION; GRAFT VERSUS HOST REACTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MUCOSA INFLAMMATION; NEUTROPENIA; NONHUMAN; OBSERVATIONAL STUDY; PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; SEPTIC SHOCK; STREPTOCOCCUS PNEUMONIAE;

EID: 84902084792     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2014.37     Document Type: Article

References (40)

1. Mikulska M, Del Bono V, Raiola AM, Bruno B, Gualandi F, Occhini D et al. Bloodstream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transplant 2009; 15: 47-53.
2. Almyroudis NG, Fuller A, Jakubowski A, Sepkowitz K, Jaffe D, Small TN et al. Pre-and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients. Transpl Infect Dis 2005; 7: 11-17.
3. Poutsiaka DD, Price LL, Ucuzian A, Chan GW, Miller KB, Snydman DR. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transplant 2007; 40: 63-70.
4. Liu CY, Lai YC, Huang LJ, Yang YW, Chen TL, Hsiao LT et al. Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients. Bone Marrow Transplant 2011; 46: 1231-1239.
5. Dettenkofer M, Ebner W, Bertz H, Babikir R, Finke J, Franf U et al. Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation. Bone Marrow Transplant 2003; 31: 795-801.
6. Yuen KY, Woo PCY, HUi CH, Luk WK, Chen FE, Lie AKW et al. Unique risk factors for bacteremia in allogeneic bone marrow transplant recipients before and after engraftment. Bone Marrow Transplant 1998; 21: 1137-1143.
7. Collin BA, Leather HL, Wingard JR, Ramphal R. Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant recipients. Clin Infect Dis 2001; 33: 947-953.
8. Garnica M, Maiolino A, Nucci M. Factors associated with bacteremia due to multidrug-resistant Gram-negative bacilli in hematopoietic stem cell transplant recipients. Braz J Med Biol Res 2009; 42: 289-293.
9. Mitchell AE, Derrington P, Turner P, Hunt LP, Oakhill A, Marks DI. Gram-negative bacteremia (GNB) after 428 unrelated donor bone marrow transplants (UD-BMT): risk factors, prophylaxis, therapy and outcome. Bone Marrow Transplant 2004; 33: 303-310.
10. Sparrelid E, Hägglund H, Remberger M, Ringdén O, Lönnqvist B, Ljungman P et al. Bacteremia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection. Bone Marrow Transplant 1998; 22: 795-800.
11. Zinner SH. Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on Gram-positive and resistant bacteria. Clin Infect Dis 1999; 29: 490-494.
12. Gudiol C, Bodro M, Simonetti A, Tubau F, González-Barca E, Cisnal M et al. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients. Clin Microbiol Infect 2013; 19: 474-479.
13. Mikulska M, del Bono V, Bruzzi P, Raiola AM, Gualandi F, van Lint MT et al. Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients. Infection 2012; 40: 271-278.
14. Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995; 15: 825-828.
15. Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005; 11: 945-956.
16. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012; 18: 268-281.
17. Miller AN, Glode A, Hogan KR, Schaub C, Kramer C, Stuart RK et al. Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant 2011; 17: 1176-1181.
18. Sánchez-Ortega I, Patiño B, Arnan M, Peralta T, Parody R, Gudiol C et al. Clinical efficacy and safety of primary antifungal prophylaxis with posaconazole vs itra-conazole in allogeneic blood and marrow transplantation. Bone Marrow Transplant 2011; 46: 733-739.
19. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. (20th Informational Supplement. CLSI document M100-S20) Clinical and Laboratory Standards Institute: (Wayne PA USA 2010).
20. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 8th edn. (Approved Standard M07-A8) (CLSI: Wayne, PA, USA, 2009).
21. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement. (CLSI document M100-S22) (CLSI: Wayne PA USA 2012).
22. Hosmer DW, Lemeshow S. Logistic regression: variable selection. In: Hosmer DW, Lemeshow S (eds). Applied Logistic Regression, 2nd edn. John Willey & Sons: New York, NY, USA, 2000.
23. Poutsiaka DD, Munson D, Price LL, Chan GW, Snydman DR. Blood stream infection (BSI) and acute graft versus host disease (GVHD) after hematopoietic stem cell transplantation (HSCT) are associated. Bone Marrow Transplant 2011; 46: 300-307.
24. Sosa R, Weiden PL, Storb R, Syrotuck J, Thomas ED. Granulocyte function in human allogeneic marrow graft recipients. Exp Hematol 1980; 8: 1183-1189.
25. Lum LG. The kinetics of immune reconstitution after bone marrow transplantation. Blood 1987; 69: 369-380.
26. Cupps TR, Fauci AS. Corticosteroid-mediated immunoregulation in man. Immunol Rev 1982; 65: 133-155.
27. Ariza-Heredia EJ, Nesher L, Chemaly RF. Cytomegalovirus diseases after hematopoietic stem cell transplantation: a mini-review. Cancer Lett 2013; 342: 1-8.
28. Oliveira AL, de Souza M, Carvalho-Dias VM, Ruiz MA, Silla L, Tanaka PYet al. Epidemiology of bacteremia and factors associates with multidrug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients. Bone Marrow Transplant 2007; 39: 775-781.
29. Kumar D, Humar A, Plevneshi A, Siegal D, Franke N, Green K et al. Invasive pneumococcal disease in adult hematopoietic stem cell transplant recicpients: a decade of prospective population-based surveillance. Bone Marrow Transplant 2008; 41: 743-747.
30. Kulkarni S, Powles R, Treleaven J, Riley U, Singhal S, Horton C et al. Chronic graft versus host disease is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplants. Blood 2000; 95: 3683-3686.
31. Youseef S, Rodríguez G, Rolston KV, Champlin RE, Raad I, Safdar A. Streptococcus pneumoniae infections in 47 hematopoietic stem cell transplantation recipients: clinical characteristics of infections and vaccine-breakthrough infections, 1989-2005. Medicine (Baltimore) 2007; 86: 69-77.
32. Engelhard D, Cordonnier C, Shaw PJ, Parkalli T, Guenther C, Martino R et al. Early and late invasive pneumococcal infection following stem cell trasn-plantation: a European Bone Marrow Transplantation survey. Br J Hematol 2002; 117: 444-450.
33. Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant 2009; 15: 1143-1238.
34. Song JH. Advances in pneumococcal antibiotic resistance. Expert Rev Respir Med 2013; 7: 491-498.
35. Ljungman P, Cordonnier C, Einsele H, Englund J, Machado CM, Storek J et al. Vaccination of hematopoietic cell transplant recipients. Bone Marrow Transplant 2009; 44: 521-526.
36. Ljungman P, Small TN. Vaccination of SCT recipients. Bone Marrow Transplant 2011; 46: 621.
37. Cordonnier C, Labopin M, Chesnel V, Ribaud P, Camara Rde L, Martino R et al. Immune response to the 23-valent polysaccharide pneumococcal vaccine (PPV23) after the 7-valent conjugate vaccine (PCV7) in allogeneic stem cell transplant (SCT) recipients: results of the EBMT IDWP01 trial. Vaccine 2010; 28: 2730-2734.
38. Leibovici L, Shraga I, Drucker M, Konigsberger H, Samra Z, Pitlik SD. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998; 244: 379-386.
39. Engelhard D, Elishoov H, Strauss N, Naparstek E, Nagler A, Simhon A et al. Nosocomial coagulase-negative staphylococcal infections in bone marrow transplantation recipients with central vein catheter. A 5-year prospective study. Transplantation 1996; 61: 430-434.
40. Marron A, Carratalà J, González-Barca E, Fernández-Sevilla A, Alcalde F, Gudiol F. Serious complications of bacteremia caused by viridans streptococci in neu-tropenic patients with cancer. Clin Infect Dis 2000; 31: 1126-1130.