Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: A single-blinded pilot study

American Journal of Gastroenterology

Volumn 109, Issue 6, 2014, Pages 895-902

  Navaneethan, Udayakumar ^a   Gutierrez, Norma G ^a   Venkatesh, Preethi G K ^a   Jegadeesan, Ramprasad ^a   Zhang, Renilang ^a   Jang, Sunguk ^a   Sanaka, Madhusudhan R ^a   Vargo, John J ^a   Parsi, Mansour A ^a   Feldstein, Ariel E ^b   Stevens, Tyler ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PALMITOYL 2 (4 OXOBUTYRYL) SN GLYCERO 3 PHOSPHATIDYLCHOLINE; 1 PALMITOYL 2 (5 OXOVALERYL) SN GLYCERO 3 PHOSPHATIDYLCHOLINE; 1 PALMITOYL 2 (9 OXONONANOYL) SN GLYCERO 3 PHOSPHATIDYLCHOLINE; 1 PALMITOYL 2 ARACHIDONOYL SN GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 AZELAOYL SN GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 DOCOSAHEXAENOYL SN GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 GLUTARYL SN GLYCERO 3 PHOSPHATIDYLCHOLINE; 1 PALMITOYL 2 GLUTARYL SN GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 LINOLEOY L GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 SUCCINOYL SN GLYCERO 3 PHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BILE; BILE DUCT CARCINOMA; CHOLESTASIS; CLINICAL ARTICLE; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; OXIDATION; PANCREAS CANCER; PILOT STUDY; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SINGLE BLIND PROCEDURE;

ADULT; AGED; AGED, 80 AND OVER; BILE; BILIARY TRACT DISEASES; CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOSPHOLIPIDS; PILOT PROJECTS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SINGLE-BLIND METHOD; TANDEM MASS SPECTROMETRY;

EID: 84902075007     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2014.60     Document Type: Article

References (22)

1. Parsi MA. Peroral cholangioscopy in the new millennium. World J Gastroenterol 2011;17;1-6
2. Parsi MA, Deepinder F, Lopez R, et al. Factors aff ecting the yield of brush cytology for the diagnosis of pancreatic and biliary cancers. Pancreas 2011;40;52-4
3. Ponchon T, Gagnon P, Berger F, et al. Value of endobiliary brush cytology and biopsies for the diagnosis of malignant bile duct stenosis: Results of a prospective study. Gastrointest Endosc 1995;42;565-72
4. Baron TH, Harewood GC, Rumalla A, et al. A prospective comparison of digital image analysis and routine cytology for the identifi cation of malignancy in biliary tract strictures. Clin Gastroenterol Hepatol 2004;2;214-9. (Pubitemid 38293308
5. Lee JG, Leung JW, Baillie J, et al. Benign, dysplastic, or malignant making sense of endoscopic bile duct brush cytology: Results in 149 consecutive patients. Am J Gastroenterol 1995;90;722-6
6. Kocjan G, Smith AN. Bile duct brushings cytology: Potential pitfalls in diagnosis. Diagn Cytopathol 1997;16;358-63. (Pubitemid 27197713
7. Parsi MA, Li A, Li CP, et al. DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease. Clin Gastroenterol Hepatol 2008;6;1270-8
8. Lazaridis KN, Gores GJ. Cholangiocarcinoma. Gastroenterology 2005;128;1655-67
9. Gores GJ. Cholangiocarcinoma: Current concepts and insights. Hepatology 2003;37;961-9. (Pubitemid 36538671
10. Blechacz B, Gores GJ. Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment. Hepatology 2008;48;308-21. (Pubitemid 351975555
11. Volinsky R, Kinnunen PK. Oxidized phosphatidylcholines in membranelevel cellular signaling: From biophysics to physiology and molecular pathology. FEBS J 2013;280;2806-16
12. Navaneethan U, Gutierrez NG, Jegadeesan R, et al. Vascular endothelial growth factor levels in bile distinguishes pancreatic cancer from other etiologies of biliary stricture: A pilot study. Dig Dis Sci 2013;58;2986-92
13. Hwang SD, Kim YJ, Lee SH, et al. Iodinated contrast media can induce long-lasting oxidative stress in hemodialysis patients. Yonsei Med J 2013;54;1438-46
14. Stevens T, Berk MP, Lopez R, et al. Lipidomic profi ling of serum and pancreatic fl uid in chronic pancreatitis. Pancreas 2012;41;518-22
15. Trikudanathan G, Navaneethan U, Njei B, et al. Diagnostic yield of bile duct brushings for cholangiocarcinoma in primary sclerosing cholangitis: A systematic review and meta-Analysis. Gastrointest Endosc 2013 pii: S0016-5107(13)02400-0; doi:10.1016/j.gie.2013.09.015 (e-pub ahead of print
16. Kipp BR, Stadheim LM, Halling SA, et al. A comparison of routine cytology and fl uorescence in situ hybridization for the detection of malignant bile duct strictures. Am J Gastroenterol 2004;99;1675-81. (Pubitemid 39237490
17. Navaneethan U, Njei B, Vargo JJ, et al. Fluorescent in situ hybridization for diagnosis of cholangiocarcinoma in primary sclerosing cholangitis: A systematic review and meta-Analysis. Gastrointest Endosc 2013 pii: S0016-5107(13)02532-7; doi:10.1016/j.gie.2013.11.001 (e-pub ahead of print
18. Fritcher EG, Kipp BR, Halling KC, et al. A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatobiliary strictures. Gastroenterology 2009;136;2180-6
19. Gonda TA, Glick MP, Sethi A, et al. Polysomy and p16 deletion by fl uorescence in situ hybridization in the diagnosis of indeterminate biliary strictures. Gastrointest Endosc 2012;75;74-9
20. Lankisch TO, Metzger J, Negm AA, et al. Bile proteomic profi les diff erentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology 2011;53;875-84
21. Metzger J, Negm AA, Plentz RR, et al. Urine proteomic analysis diff erentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut 2013;62;122-30
22. Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2011;306;1549-56