Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice

Experimental Eye Research

Volumn 125, Issue , 2014, Pages 9-19

  Biswas, Sondip K ^a   Brako, Lawrence ^a   Lo, Woo Kuen ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

AQP0; Caveolin 1 knockout; Fiber cell membrane; Lens; Mouse; Square array junctions

Indexed keywords

CAVEOLIN 1; CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL MEMBRANE; CELL SHAPE; CONTROLLED STUDY; EXTRACELLULAR SPACE; FREEZE FRACTURE; IMMUNOFLUORESCENCE; IMMUNOGOLD LABELING; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUARE ARRAY JUNCTION; VISUAL SYSTEM PARAMETERS;

AQP0; CAVEOLIN-1 KNOCKOUT; FIBER CELL MEMBRANE; LENS; MOUSE; SQUARE ARRAY JUNCTIONS;

ANIMALS; AQUAPORINS; CAPSULE OPACIFICATION; CAVEOLIN 1; CELL SHAPE; CHOLESTEROL; DISEASE MODELS, ANIMAL; EYE PROTEINS; INTERCELLULAR JUNCTIONS; LENS, CRYSTALLINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 84901989777     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.05.014     Document Type: Article

References (33)

1. Alcala J., Lieska N., Maisel H. Protein composition of bovine lens cortical fiber cell membranes. Exp. Eye Res. 1975, 21:581-595.
2. Alcala J., Valentine J., Maisel H. Human lens fiber cell plasma membranes. I. Isolation, polypeptide composition and changes associated with ageing. Exp. Eye Res. 1980, 30:659-677.
3. Biswas S.K., Jiang J.X., Lo W.K. Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens. Mol. Vis. 2009, 15:1492-1508.
4. Biswas S.K., Lo W.K. Gap junctions contain different amounts of cholesterol which undergo unique sequestering processes during fiber cell differentiation in the embryonic chicken lens. Mol. Vis. 2007, 13:345-359.
5. Cenedella R.J., Neely A.R., Sexton P. Multiple forms of 22 kDa caveolin-1 alpha present in bovine lens cells could reflect variable palmitoylation. Exp. Eye Res. 2006, 82:229-235.
6. Cenedella R.J., Sexton P.S., Brako L., Lo W.K., Jacob R.F. Status of caveolin-1 in various membrane domains of the bovine lens. Exp. Eye Res. 2007, 85:473-481.
7. Costello M.J., McIntosh T.J., Robertson J.D. Membrane specializations in mammalian lens fiber cells: distribution of square arrays. Curr. Eye Res. 1985, 4:1183-1201.
8. Costello M.J., McIntosh T.J., Robertson J.D. Distribution of gap junctions and square array junctions in the mammalian lens. Investig. Ophthalmol. Vis. Sci. 1989, 30:975-989.
9. Dickson D.H., Crock G.W. Interlocking patterns on primate lens fibers. Investig. Ophthalmol. 1972, 11:809-815.
10. Dunia I., Recouvreur M., Nicolas P., Kumar N., Bloemendal H., Benedetti E.L. Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling. J.Cell Sci. 1998, 111(Pt 15):2109-2120.
11. Gorin M.B., Yancey S.B., Cline J., Revel J.P., Horwitz J. The major intrinsic protein (MIP) of the bovine lens fiber membrane: characterization and structure based on cDNA cloning. Cell 1984, 39:49-59.
12. Horwitz J., Robertson N.P., Wong M.M., Zigler J.S., Kinoshita J.H. Some properties of lens plasma membrane polypeptides isolated from normal human lenses. Exp. Eye Res. 1979, 28:359-365.
13. Johnson K.R., Sas D.F., Johnson R.G. MP26, a protein of intercellular junctions in the bovine lens: electrophoretic and chromatographic characterization. Exp. Eye Res. 1991, 52:629-639.
14. Kistler J., Bullivant S. Lens gap junctions and orthogonal arrays are unrelated. FEBS Lett. 1980, 111:73-78.
15. Kuck J.F., Kuwabara T., Kuck K.D. The Emory mouse cataract: an animal model for human senile cataract. Curr. Eye Res. 1981, 1:643-649.
16. Kuszak J.R., Ennesser C.A., Umlas J., sai-Kaplan M.S., Weinstein R.S. The ultrastructure of fiber cells in primate lenses: a model for studying membrane senescence. J.Ultrastruct. Mol. Struct. Res. 1988, 100:60-74.
17. Kuwabara T. The maturation of the lens cell: a morphologic study. Exp. Eye Res. 1975, 20:427-443.
18. Lin D., Zhou J., Zelenka P.S., Takemoto D.J. Protein kinase Cgamma regulation of gap junction activity through caveolin-1-containing lipid rafts. Investig. Ophthalmol. Vis. Sci. 2003, 44:5259-5268.
19. Lo W.K., Harding C.V. Square arrays and their role in ridge formation in human lens fibers. J.Ultrastruct. Res. 1984, 86:228-245.
20. Lo W.K., Kuck J.F. Alterations in fiber cell membranes of Emory mouse cataract: a morphologic study. Curr. Eye Res. 1987, 6:433-444.
21. Lo W.K., Zhou C.J., Reddan J. Identification of caveolae and their signature proteins caveolin 1 and 2 in the lens. Exp. Eye Res. 2004, 79:487-498.
22. Michea L.F., Andrinolo D., Ceppi H., Lagos N. Biochemical evidence for adhesion-promoting role of major intrinsic protein isolated from both normal and cataractous human lenses. Exp. Eye Res. 1995, 61:293-301.
23. Roy D., Spector A., Farnsworth P.N. Human lens membrane: comparison of major intrinsic polypeptides from young and old lenses isolated by a new methodology. Exp. Eye Res. 1979, 28:353-358.
24. Rujoi M., Jin J., Borchman D., Tang D., Yappert M.C. Isolation and lipid characterization of cholesterol-enriched fractions in cortical and nuclear human lens fibers. Investig. Ophthalmol. Vis. Sci. 2003, 44:1634-1642.
25. Schubert A.L., Schubert W., Spray D.C., Lisanti M.P. Connexin family members target to lipid raft domains and interact with caveolin-1. Biochemistry 2002, 41:5754-5764.
26. Sexton P.S., Neely A.R., Cenedella R.J. Distribution of caveolin-1 in bovine lens and redistribution in cultured bovine lens epithelial cells upon confluence. Exp. Eye Res. 2004, 78:75-82.
27. Simon S.A., Zampighi G., McIntosh T.J., Costello M.J., Ting-beall H.P., Robertson J.D. The structure of junctions between lens fiber cells. Biosci. Rep. 1982, 2:333-341.
28. Takemoto L., Takehana M., Horwitz J. Covalent changes in MIP26K during aging of the human lens membrane. Investig. Ophthalmol. Vis. Sci. 1986, 27:443-446.
29. Willekens B., Vrensen G. The three-dimensional organization of lens fibers in the rhesus monkey. Graefes Arch. Clin. Exp. Ophthalmol. 1982, 219:112-120.
30. Yoon K.H., Blankenship T., Shibata B., FitzGerald P.G. Resisting the effects of aging: a function for the fiber cell beaded filament. Investig Ophthalmol. Vis. Sci. 2008, 49:1030-1036.
31. Zampighi G., Simon S.A., Robertson J.D., McIntosh T.J., Costello M.J. On the structural organization of isolated bovine lens fiber junctions. J.Cell Biol. 1982, 93:175-189.
32. Zampighi G.A., Hall J.E., Ehring G.R., Simon S.A. The structural organization and protein composition of lens fiber junctions. J.Cell Biol. 1989, 108:2255-2275.
33. Zampighi G.A., Kreman M., Lanzavecchia S., Turk E., Eskandari S., Zampighi L., Wright E.M. Structure of functional single AQP0 channels in phospholipid membranes. J.Mol. Biol. 2003, 325:201-210.