-
1
-
-
40849086434
-
The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro
-
O'Brien, P.M. et al. (2008) The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. Br. J. Cancer, 98, 1085-1093.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 1085-1093
-
-
O'Brien, P.M.1
-
2
-
-
0037135579
-
EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response
-
Henderson, M.J. et al. (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J. Biol. Chem., 277, 26468-26478.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26468-26478
-
-
Henderson, M.J.1
-
3
-
-
82355192264
-
Identification of phosphorylation sites on the E3 ubiquitin ligase UBR5/EDD
-
Bethard, J.R. et al. (2011) Identification of phosphorylation sites on the E3 ubiquitin ligase UBR5/EDD. J. Proteomics, 75, 603-609.
-
(2011)
J. Proteomics
, vol.75
, pp. 603-609
-
-
Bethard, J.R.1
-
4
-
-
0038351827
-
Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs
-
Eblen, S.T. et al. (2003) Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J. Biol. Chem., 278, 14926-14935.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14926-14935
-
-
Eblen, S.T.1
-
5
-
-
11844287006
-
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors
-
Rechsteiner, M. et al. (2005) Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors. Trends Cell Biol., 15, 27-33.
-
(2005)
Trends Cell Biol.
, vol.15
, pp. 27-33
-
-
Rechsteiner, M.1
-
6
-
-
9644300915
-
The proteasome: a proteolytic nanomachine of cell regulation and waste disposal
-
Wolf, D.H. et al. (2004) The proteasome: a proteolytic nanomachine of cell regulation and waste disposal. Biochim. Biophys. Acta, 1695, 19-31.
-
(2004)
Biochim. Biophys. Acta
, vol.1695
, pp. 19-31
-
-
Wolf, D.H.1
-
7
-
-
0032585636
-
Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs
-
Callaghan, M.J. et al. (1998) Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. Oncogene, 17, 3479-3491.
-
(1998)
Oncogene
, vol.17
, pp. 3479-3491
-
-
Callaghan, M.J.1
-
8
-
-
38149102266
-
The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints
-
Munoz, M.A. et al. (2007) The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints. Cell Cycle, 6, 3070-3077.
-
(2007)
Cell Cycle
, vol.6
, pp. 3070-3077
-
-
Munoz, M.A.1
-
9
-
-
84865232294
-
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
-
Gudjonsson, T. et al. (2012) TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell, 150, 697-709.
-
(2012)
Cell
, vol.150
, pp. 697-709
-
-
Gudjonsson, T.1
-
10
-
-
33845966077
-
EDD mediates DNA damage-induced activation of CHK2
-
Henderson, M.J. et al. (2006) EDD mediates DNA damage-induced activation of CHK2. J. Biol. Chem., 281, 39990-40000.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39990-40000
-
-
Henderson, M.J.1
-
11
-
-
0042785949
-
EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer
-
Clancy, J.L. et al. (2003) EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene, 22, 5070-5081.
-
(2003)
Oncogene
, vol.22
, pp. 5070-5081
-
-
Clancy, J.L.1
-
12
-
-
0842347491
-
Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma
-
Fuja, T.J. et al. (2004) Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res., 64, 942-951.
-
(2004)
Cancer Res.
, vol.64
, pp. 942-951
-
-
Fuja, T.J.1
-
13
-
-
0036644869
-
Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers
-
Mori, Y. et al. (2002) Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res., 62, 3641-3645.
-
(2002)
Cancer Res.
, vol.62
, pp. 3641-3645
-
-
Mori, Y.1
-
14
-
-
0030966025
-
Comparative genomic hybridization analysis of chromosomal changes occurring during development of acquired resistance to cisplatin in human ovarian carcinoma cells
-
Wasenius, V.M. et al. (1997) Comparative genomic hybridization analysis of chromosomal changes occurring during development of acquired resistance to cisplatin in human ovarian carcinoma cells. Genes Chromosomes Cancer, 18, 286-291.
-
(1997)
Genes Chromosomes Cancer
, vol.18
, pp. 286-291
-
-
Wasenius, V.M.1
-
15
-
-
0034747719
-
Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2
-
Eblen, S.T. et al. (2001) Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2. Mol. Cell. Biol., 21, 249-259.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 249-259
-
-
Eblen, S.T.1
-
16
-
-
0031876318
-
mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response
-
Chao, J.R. et al. (1998) mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol., 18, 4883-4898.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 4883-4898
-
-
Chao, J.R.1
-
17
-
-
23044506285
-
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
-
Landen, C.N. Jr et al. (2005) Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res., 65, 6910-6918.
-
(2005)
Cancer Res.
, vol.65
, pp. 6910-6918
-
-
Landen, C.N.1
-
18
-
-
33846978083
-
Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer
-
Landen, C.N. et al. (2006) Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer. Cancer Biol. Ther., 5, 1708-1713.
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 1708-1713
-
-
Landen, C.N.1
-
19
-
-
79953719964
-
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
-
Ola, M.S. et al. (2011) Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol. Cell. Biochem., 351, 41-58.
-
(2011)
Mol. Cell. Biochem.
, vol.351
, pp. 41-58
-
-
Ola, M.S.1
-
20
-
-
0242522206
-
Regulation of apoptosis by Bcl-2 family proteins
-
Burlacu, A. (2003) Regulation of apoptosis by Bcl-2 family proteins. J. Cell. Mol. Med., 7, 249-257.
-
(2003)
J. Cell. Mol. Med.
, vol.7
, pp. 249-257
-
-
Burlacu, A.1
-
21
-
-
78649971327
-
Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma
-
Hadji, A. et al. (2010) Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma. Apoptosis, 15, 1529-1539.
-
(2010)
Apoptosis
, vol.15
, pp. 1529-1539
-
-
Hadji, A.1
-
22
-
-
34347350211
-
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
Ding, Q. et al. (2007) Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol. Cell. Biol., 27, 4006-4017.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
-
23
-
-
79551675617
-
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin
-
Hay-Koren, A. et al. (2011) The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol. Biol. Cell, 22, 399-411.
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 399-411
-
-
Hay-Koren, A.1
-
24
-
-
0037075791
-
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease
-
Martinez, A. et al. (2002) First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J. Med. Chem., 45, 1292-1299.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1292-1299
-
-
Martinez, A.1
-
25
-
-
0029776032
-
A molecular mechanism for the effect of lithium on development
-
Klein, P.S. et al. (1996) A molecular mechanism for the effect of lithium on development. Proc. Natl Acad. Sci. U. S. A., 93, 8455-8459.
-
(1996)
Proc. Natl Acad. Sci. U. S. A.
, vol.93
, pp. 8455-8459
-
-
Klein, P.S.1
-
26
-
-
0035029426
-
Molecular targets of lithium action
-
Phiel, C.J. et al. (2001) Molecular targets of lithium action. Annu. Rev. Pharmacol. Toxicol., 41, 789-813.
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 789-813
-
-
Phiel, C.J.1
-
27
-
-
29244456731
-
Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle
-
Kaidanovich-Beilin, O. et al. (2006) Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J. Pharmacol. Exp. Ther., 316, 17-24.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 17-24
-
-
Kaidanovich-Beilin, O.1
-
28
-
-
34547098724
-
Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice
-
Rao, R. et al. (2007) Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice. Diabetologia, 50, 452-460.
-
(2007)
Diabetologia
, vol.50
, pp. 452-460
-
-
Rao, R.1
-
29
-
-
28844447276
-
EphA2 as a target for ovarian cancer therapy
-
Landen, C.N. et al. (2005) EphA2 as a target for ovarian cancer therapy. Expert Opin. Ther. Targets, 9, 1179-1187.
-
(2005)
Expert Opin. Ther. Targets
, vol.9
, pp. 1179-1187
-
-
Landen, C.N.1
-
30
-
-
33748364149
-
Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy
-
Halder, J. et al. (2006) Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin. Cancer Res., 12, 4916-4924.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4916-4924
-
-
Halder, J.1
-
31
-
-
40949126550
-
Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
-
Merritt, W.M. et al. (2008) Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth. J. Natl Cancer Inst., 100, 359-372.
-
(2008)
J. Natl Cancer Inst.
, vol.100
, pp. 359-372
-
-
Merritt, W.M.1
-
32
-
-
53049109358
-
Targeting aurora kinase with MK-0457 inhibits ovarian cancer growth
-
Lin, Y.G. et al. (2008) Targeting aurora kinase with MK-0457 inhibits ovarian cancer growth. Clin. Cancer Res., 14, 5437-5446.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5437-5446
-
-
Lin, Y.G.1
-
33
-
-
70349330919
-
Liposomal siRNA for ovarian cancer
-
Mangala, L.S. et al. (2009) Liposomal siRNA for ovarian cancer. Methods Mol. Biol., 555, 29-42.
-
(2009)
Methods Mol. Biol.
, vol.555
, pp. 29-42
-
-
Mangala, L.S.1
-
34
-
-
80655144781
-
Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death
-
Nick, A.M. et al. (2011) Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J. Natl Cancer Inst., 103, 1596-1612.
-
(2011)
J. Natl Cancer Inst.
, vol.103
, pp. 1596-1612
-
-
Nick, A.M.1
-
35
-
-
79954624183
-
Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis
-
Chakravarty, D. et al. (2011) Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis. Clin. Cancer Res., 17, 2250-2259.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 2250-2259
-
-
Chakravarty, D.1
-
36
-
-
0036313642
-
Increased MCL-1 expression is associated with poor prognosis in ovarian carcinomas
-
Shigemasa, K. et al. (2002) Increased MCL-1 expression is associated with poor prognosis in ovarian carcinomas. Jpn. J. Cancer Res., 93, 542-550.
-
(2002)
Jpn. J. Cancer Res.
, vol.93
, pp. 542-550
-
-
Shigemasa, K.1
-
37
-
-
74049125626
-
Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis
-
Brotin, E. et al. (2010) Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis. Int. J. Cancer, 126, 885-895.
-
(2010)
Int. J. Cancer
, vol.126
, pp. 885-895
-
-
Brotin, E.1
-
38
-
-
70949089720
-
Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells
-
Simonin, K. et al. (2009) Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells. Mol. Cancer Ther., 8, 3162-3170.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 3162-3170
-
-
Simonin, K.1
-
39
-
-
84856060485
-
PDGF upregulates Mcl-1 through activation of ß-catenin and HIF-1a-dependent signaling in human prostate cancer cells
-
Iqbal, S. et al. (2012) PDGF upregulates Mcl-1 through activation of ß-catenin and HIF-1a-dependent signaling in human prostate cancer cells. PLoS One, 7, e30764.
-
(2012)
PLoS One
, vol.7
-
-
Iqbal, S.1
-
40
-
-
85047699682
-
Direct repression of the Mcl-1 promoter by E2F1
-
Croxton, R. et al. (2002) Direct repression of the Mcl-1 promoter by E2F1. Oncogene, 21, 1359-1369.
-
(2002)
Oncogene
, vol.21
, pp. 1359-1369
-
-
Croxton, R.1
-
41
-
-
85047698254
-
Differences in DNA binding properties between E2F1 and E2F4 specify repression of the Mcl-1 promoter
-
Croxton, R. et al. (2002) Differences in DNA binding properties between E2F1 and E2F4 specify repression of the Mcl-1 promoter. Oncogene, 21, 1563-1570.
-
(2002)
Oncogene
, vol.21
, pp. 1563-1570
-
-
Croxton, R.1
-
42
-
-
58149263382
-
A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2
-
Magklara, A. et al. (2009) A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2. Mol. Endocrinol., 23, 61-73.
-
(2009)
Mol. Endocrinol.
, vol.23
, pp. 61-73
-
-
Magklara, A.1
-
43
-
-
84867038926
-
Secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers
-
Saran, U. et al. (2012) Secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers. BMC Cell Biol., 13, 25.
-
(2012)
BMC Cell Biol.
, vol.13
, pp. 25
-
-
Saran, U.1
-
44
-
-
78651515618
-
Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer
-
Matsumura, N. et al. (2011) Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res., 21, 74-82.
-
(2011)
Genome Res.
, vol.21
, pp. 74-82
-
-
Matsumura, N.1
-
45
-
-
79551553893
-
MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance
-
Ye, G. et al. (2011) MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance. J. Cell Sci., 124, 359-368.
-
(2011)
J. Cell Sci.
, vol.124
, pp. 359-368
-
-
Ye, G.1
-
46
-
-
20444448808
-
An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell lines
-
Smith, J.A. et al. (2005) An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell lines. Gynecol. Oncol., 98, 141-145.
-
(2005)
Gynecol. Oncol.
, vol.98
, pp. 141-145
-
-
Smith, J.A.1
-
47
-
-
84859771379
-
Molecular mechanisms of cisplatin resistance
-
Galluzzi, L. et al. (2012) Molecular mechanisms of cisplatin resistance. Oncogene, 31, 1869-1883.
-
(2012)
Oncogene
, vol.31
, pp. 1869-1883
-
-
Galluzzi, L.1
|